| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
5,878,015 |
8,758,000 |
15.59% |
|
|
| 2 |
Scale Management, LLC |
3,973,217 |
5,920,000 |
10.54% |
|
|
| 3 |
Avoro Capital Advisors LLC |
3,575,000 |
5,327,000 |
9.48% |
|
|
| 4 |
NORTH RUN CAPITAL, LP |
3,497,100 |
5,211,000 |
9.27% |
|
|
| 5 |
Polaris Venture Management Co IV LLC |
3,148,355 |
4,691,000 |
8.35% |
|
|
| 6 |
Palo Alto Investors LP |
3,013,793 |
4,491,000 |
7.99% |
|
|
| 7 |
GREAT POINT PARTNERS LLC |
2,637,969 |
3,931,000 |
7.00% |
|
|
| 8 |
ARMISTICE CAPITAL, LLC |
2,472,000 |
3,683,000 |
6.55% |
|
|
| 9 |
STONEPINE CAPITAL MANAGEMENT, LLC |
1,907,190 |
2,842,000 |
5.06% |
|
|
| 10 |
VANGUARD GROUP INC |
1,771,629 |
2,640,000 |
4.70% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
1,005,815 |
1,499,000 |
2.67% |
|
|
| 12 |
ACUTA CAPITAL PARTNERS, LLC |
974,318 |
1,452,000 |
2.58% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
973,068 |
1,450,000 |
2.58% |
|
|
| 14 |
J. Goldman & Co LP |
668,360 |
996,000 |
1.77% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
274,269 |
409,000 |
0.73% |
|
|
| 16 |
ORBIMED ADVISORS LLC |
250,000 |
373,000 |
0.66% |
|
|
| 17 |
Parkwood LLC |
228,123 |
340,000 |
0.61% |
|
|
| 18 |
SPHERA FUNDS MANAGEMENT LTD. |
200,715 |
299,000 |
0.53% |
|
|
| 19 |
Spark Investment Management LLC |
176,300 |
262,000 |
0.47% |
|
|
| 20 |
GEODE CAPITAL MANAGEMENT, LLC |
145,874 |
217,000 |
0.39% |
|
|
| 21 |
BlackRock Fund Advisors |
143,873 |
214,000 |
0.38% |
|
|
| 22 |
MILLENNIUM MANAGEMENT LLC |
106,100 |
158,000 |
0.28% |
|
|
| 23 |
NORTHERN TRUST CORP |
105,320 |
157,000 |
0.28% |
|
|
| 24 |
PNC FINANCIAL SERVICES GROUP, INC. |
95,100 |
142,000 |
0.25% |
|
|
| 25 |
Weiss Multi-Strategy Advisers LLC |
85,000 |
127,000 |
0.23% |
|
|
| 26 |
STRS OHIO |
43,569 |
64,000 |
0.11% |
|
|
| 27 |
Livingston Group Asset Management CO (operating as Southport Capital Management) |
41,550 |
62,000 |
0.11% |
|
|
| 28 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
39,994 |
60,000 |
0.11% |
|
|
| 29 |
WOLVERINE TRADING LP /BD |
35,917 |
54,000 |
0.10% |
|
|
| 30 |
Bank of New York Mellon Corp |
28,838 |
43,000 |
0.08% |
|
|
| 31 |
ZACKS INVESTMENT MANAGEMENT |
25,341 |
38,000 |
0.07% |
|
|
| 32 |
STATE STREET CORP |
22,877 |
34,000 |
0.06% |
|
|
| 33 |
Virtu KCG Holdings LLC |
21,543 |
32,000 |
0.06% |
|
|
| 34 |
GUGGENHEIM CAPITAL LLC |
18,553 |
28,000 |
0.05% |
|
|
| 35 |
CUTLER GROUP LLC / CA |
17,286 |
25,000 |
0.04% |
|
|
| 36 |
INVESTMENT CENTERS OF AMERICA INC |
17,400 |
25,000 |
0.04% |
|
|
| 37 |
CITADEL ADVISORS LLC |
14,900 |
22,000 |
0.04% |
Call |
|
| 38 |
BAYESIAN CAPITAL MANAGEMENT, LP |
11,300 |
17,000 |
0.03% |
|
|
| 39 |
Southeast Asset Advisors, LLC |
10,000 |
15,000 |
0.03% |
|
|
| 40 |
BlackRock Institutional Trust Company, N.A. |
10,303 |
15,000 |
0.03% |
|
|
| 41 |
BlackRock Investment Management, LLC |
8,676 |
13,000 |
0.02% |
|
|
| 42 |
PRELUDE CAPITAL MANAGEMENT, LLC |
7,500 |
11,000 |
0.02% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
7,469 |
11,000 |
0.02% |
|
|
| 44 |
SIMPLEX TRADING, LLC |
7,351 |
10,000 |
0.02% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
5,720 |
8,000 |
0.01% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
2,405 |
4,000 |
0.01% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
2,340 |
3,000 |
0.01% |
|
|
| 48 |
JNBA Financial Advisors |
1,416 |
2,000 |
0.00% |
|
|
| 49 |
MORGAN STANLEY |
1,200 |
2,000 |
0.00% |
|
|
| 50 |
SIGNATUREFD, LLC |
1,416 |
2,000 |
0.00% |
|
|
