| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 14,715,786 | 67,104,000 | 12.57% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 12,205,673 | 55,658,000 | 10.43% | ||
| 3 | FMR LLC | 11,449,070 | 52,208,000 | 9.78% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,874,300 | 40,467,000 | 7.58% | ||
| 5 | Redmile Group, LLC | 8,085,945 | 36,872,000 | 6.91% | ||
| 6 | ORBIMED ADVISORS LLC | 6,402,800 | 29,197,000 | 5.47% | ||
| 7 | STATE STREET CORP | 5,260,401 | 23,988,000 | 4.49% | ||
| 8 | BlackRock Fund Advisors | 4,646,525 | 21,188,000 | 3.97% | ||
| 9 | VANGUARD GROUP INC | 3,943,569 | 17,982,000 | 3.37% | ||
| 10 | TimesSquare Capital Management, LLC | 3,873,950 | 17,665,000 | 3.31% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,738,695 | 17,048,000 | 3.19% | ||
| 12 | APEX CAPITAL, LLC | 3,600,000 | 16,416,000 | 3.08% | ||
| 13 | Artal Group S.A. | 3,000,000 | 13,680,000 | 2.56% | ||
| 14 | QVT Financial LP | 2,096,200 | 9,559,000 | 1.79% | ||
| 15 | KOPP INVESTMENT ADVISORS LLC | 2,011,900 | 9,174,000 | 1.72% | ||
| 16 | NORTHERN TRUST CORP | 1,482,400 | 6,760,000 | 1.27% | ||
| 17 | BAKER BROS. ADVISORS LP | 1,433,797 | 6,538,000 | 1.22% | ||
| 18 | DEUTSCHE BANK AG\ | 1,399,726 | 6,380,000 | 1.20% | ||
| 19 | BLACKROCK ADVISORS LLC | 1,381,344 | 6,298,000 | 1.18% | ||
| 20 | First Light Asset Management, LLC | 1,032,120 | 4,706,000 | 0.88% | ||
| 21 | Cormorant Asset Management, LP | 1,000,000 | 4,560,000 | 0.85% | ||
| 22 | PRINCIPAL FINANCIAL GROUP INC | 803,717 | 3,665,000 | 0.69% | ||
| 23 | CITY NATIONAL BANK | 652,515 | 2,976,000 | 0.56% | ||
| 24 | Bank of New York Mellon Corp | 641,143 | 2,924,000 | 0.55% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 622,519 | 2,838,000 | 0.53% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 615,115 | 2,805,000 | 0.53% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 570,348 | 2,600,000 | 0.49% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 530,901 | 2,421,000 | 0.45% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 497,211 | 2,267,000 | 0.42% | ||
| 30 | CAPITAL GUARDIAN TRUST CO | 475,000 | 2,166,000 | 0.41% | ||
| 31 | SUFFOLK CAPITAL MANAGEMENT LLC | 466,713 | 2,128,000 | 0.40% | ||
| 32 | BlackRock Group LTD | 435,512 | 1,986,000 | 0.37% | ||
| 33 | BlackRock Investment Management, LLC | 376,494 | 1,717,000 | 0.32% | ||
| 34 | GROUP ONE TRADING LLC | 370,284 | 1,689,000 | 0.32% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 347,119 | 1,583,000 | 0.30% | ||
| 36 | TD ASSET MANAGEMENT INC | 338,500 | 1,544,000 | 0.29% | ||
| 37 | Rhenman & Partners Asset Management AB | 329,199 | 1,501,000 | 0.28% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 1,484,000 | 0.28% | ||
| 39 | BlackRock Finance, Inc. | 314,957 | 1,436,000 | 0.27% | ||
| 40 | MORGAN STANLEY | 298,063 | 1,359,000 | 0.25% | ||
| 41 | SPHERA FUNDS MANAGEMENT LTD. | 285,000 | 1,300,000 | 0.24% | ||
| 42 | GOLDMAN SACHS GROUP INC | 283,885 | 1,295,000 | 0.24% | ||
| 43 | State of New Jersey Common Pension Fund D | 265,000 | 1,208,000 | 0.23% | ||
| 44 | WELLS FARGO & COMPANY/MN | 260,693 | 1,188,000 | 0.22% | ||
| 45 | Allianz Asset Management GmbH | 236,277 | 1,077,000 | 0.20% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 229,982 | 1,049,000 | 0.20% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 208,716 | 952,000 | 0.18% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 206,093 | 940,000 | 0.18% | ||
| 49 | PUTNAM INVESTMENTS LLC | 190,981 | 871,000 | 0.16% | ||
| 50 | Weiss Multi-Strategy Advisers LLC | 185,000 | 844,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
