| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Redmile Group, LLC | 19,150,650 | 68,176,000 | 15.73% | ||
| 2 | FMR LLC | 13,163,191 | 46,861,000 | 10.81% | ||
| 3 | ORBIMED ADVISORS LLC | 10,973,900 | 39,067,000 | 9.01% | ||
| 4 | VANGUARD GROUP INC | 8,677,752 | 30,893,000 | 7.13% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 8,361,069 | 29,765,000 | 6.87% | ||
| 6 | BVF INC/IL | 8,260,897 | 29,409,000 | 6.78% | ||
| 7 | BlackRock Fund Advisors | 5,247,300 | 18,680,000 | 4.31% | ||
| 8 | BAKER BROS. ADVISORS LP | 4,310,666 | 15,346,000 | 3.54% | ||
| 9 | Sarissa Capital Management LP | 4,300,000 | 15,308,000 | 3.53% | ||
| 10 | Artal Group S.A. | 3,870,000 | 13,777,000 | 3.18% | ||
| 11 | STATE STREET CORP | 3,563,329 | 12,683,000 | 2.93% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,472,853 | 12,363,000 | 2.85% | ||
| 13 | TEACHERS ADVISORS, LLC | 1,978,140 | 7,042,000 | 1.62% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 1,848,608 | 6,581,000 | 1.52% | ||
| 15 | DEUTSCHE BANK AG\ | 1,783,331 | 6,346,000 | 1.46% | ||
| 16 | CITADEL ADVISORS LLC | 1,778,761 | 6,332,000 | 1.46% | ||
| 17 | AXA S.A. | 1,685,672 | 6,001,000 | 1.38% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 1,590,403 | 5,662,000 | 1.31% | ||
| 19 | NORTHERN TRUST CORP | 1,551,799 | 5,525,000 | 1.27% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 910,869 | 3,242,000 | 0.75% | ||
| 21 | Candriam S.C.A. | 849,000 | 3,023,000 | 0.70% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 671,157 | 2,389,000 | 0.55% | ||
| 23 | Bank of New York Mellon Corp | 647,567 | 2,305,000 | 0.53% | ||
| 24 | BlackRock Investment Management, LLC | 591,989 | 2,107,000 | 0.49% | ||
| 25 | First Light Asset Management, LLC | 554,841 | 1,975,000 | 0.46% | ||
| 26 | CHICAGO EQUITY PARTNERS LLC | 554,890 | 1,975,000 | 0.46% | ||
| 27 | NEXTHERA CAPITAL LP | 521,000 | 1,855,000 | 0.43% | ||
| 28 | COLUMBUS CIRCLE INVESTORS | 517,196 | 1,841,000 | 0.42% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 515,317 | 1,835,000 | 0.42% | ||
| 30 | PRINCIPAL FINANCIAL GROUP INC | 506,024 | 1,801,000 | 0.42% | ||
| 31 | Spark Investment Management LLC | 382,200 | 1,360,000 | 0.31% | ||
| 32 | Rhenman & Partners Asset Management AB | 370,000 | 1,317,000 | 0.30% | ||
| 33 | KOPP INVESTMENT ADVISORS LLC | 360,282 | 1,283,000 | 0.30% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 338,410 | 1,205,000 | 0.28% | ||
| 35 | MACQUARIE GROUP LTD | 330,000 | 1,175,000 | 0.27% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 302,901 | 1,078,000 | 0.25% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 297,700 | 1,060,000 | 0.24% | ||
| 38 | A.R.T. Advisors, LLC | 266,988 | 950,000 | 0.22% | ||
| 39 | State of New Jersey Common Pension Fund D | 265,000 | 943,000 | 0.22% | ||
| 40 | LOS ANGELES CAPITAL MANAGEMENT LLC | 260,460 | 927,000 | 0.21% | ||
| 41 | GOLDMAN SACHS GROUP INC | 256,666 | 913,000 | 0.21% | ||
| 42 | TWO SIGMA ADVISERS, LP | 245,713 | 875,000 | 0.20% | ||
| 43 | Parallax Volatility Advisers, L.P. | 240,000 | 854,000 | 0.20% | Put | |
| 44 | CREDIT SUISSE AG/ | 236,532 | 843,000 | 0.19% | ||
| 45 | WELLS FARGO & COMPANY/MN | 231,801 | 825,000 | 0.19% | ||
| 46 | Swiss National Bank | 211,700 | 754,000 | 0.17% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 198,329 | 706,000 | 0.16% | ||
| 48 | Parallax Volatility Advisers, L.P. | 182,239 | 649,000 | 0.15% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,700 | 643,000 | 0.15% | Call | |
| 50 | RHUMBLINE ADVISERS | 180,610 | 643,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
