| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,541,491 | 136,651,000 | 12.96% | ||
| 2 | Redmile Group, LLC | 13,125,594 | 96,736,000 | 9.17% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 11,834,595 | 87,221,000 | 8.27% | ||
| 4 | BVF INC/IL | 9,405,817 | 69,321,000 | 6.57% | ||
| 5 | ORBIMED ADVISORS LLC | 9,232,310 | 68,042,000 | 6.45% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,608,100 | 56,072,000 | 5.32% | ||
| 7 | BAKER BROS. ADVISORS LP | 5,658,755 | 41,705,000 | 3.95% | ||
| 8 | BlackRock Fund Advisors | 5,635,297 | 41,532,000 | 3.94% | ||
| 9 | STATE STREET CORP | 4,871,611 | 35,903,000 | 3.40% | ||
| 10 | VANGUARD GROUP INC | 4,832,090 | 35,612,000 | 3.38% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 4,051,292 | 29,858,000 | 2.83% | ||
| 12 | TimesSquare Capital Management, LLC | 3,806,750 | 28,056,000 | 2.66% | ||
| 13 | Artal Group S.A. | 3,710,000 | 27,343,000 | 2.59% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 2,577,465 | 18,996,000 | 1.80% | ||
| 15 | Invesco Ltd. | 1,813,209 | 13,363,000 | 1.27% | ||
| 16 | FIRST MANHATTAN CO. LLC. | 1,620,000 | 11,939,000 | 1.13% | ||
| 17 | DEUTSCHE BANK AG\ | 1,620,039 | 11,937,000 | 1.13% | ||
| 18 | APEX CAPITAL, LLC | 1,550,000 | 11,424,000 | 1.08% | ||
| 19 | NORTHERN TRUST CORP | 1,461,429 | 10,770,000 | 1.02% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 1,450,173 | 10,687,000 | 1.01% | ||
| 21 | RA CAPITAL MANAGEMENT, L.P. | 1,357,584 | 10,005,000 | 0.95% | ||
| 22 | ORBIMED ADVISORS LLC | 1,100,000 | 8,107,000 | 0.77% | Call | |
| 23 | RENAISSANCE TECHNOLOGIES LLC | 1,054,652 | 7,773,000 | 0.74% | ||
| 24 | GOLDMAN SACHS GROUP INC | 1,012,359 | 7,461,000 | 0.71% | ||
| 25 | GOLDMAN SACHS GROUP INC | 990,800 | 7,302,000 | 0.69% | Put | |
| 26 | CITY NATIONAL BANK | 986,962 | 7,274,000 | 0.69% | ||
| 27 | Connor, Clark & Lunn Investment Management Ltd. | 963,100 | 7,098,000 | 0.67% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 959,100 | 7,069,000 | 0.67% | Put | |
| 29 | COLUMBUS CIRCLE INVESTORS | 950,645 | 7,006,000 | 0.66% | ||
| 30 | SPHERA FUNDS MANAGEMENT LTD. | 923,922 | 6,809,000 | 0.65% | ||
| 31 | AXA S.A. | 919,547 | 6,777,000 | 0.64% | ||
| 32 | Cormorant Asset Management, LP | 850,000 | 6,265,000 | 0.59% | ||
| 33 | TWO SIGMA INVESTMENTS, LP | 814,863 | 6,006,000 | 0.57% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 807,374 | 5,950,000 | 0.56% | ||
| 35 | First Light Asset Management, LLC | 775,726 | 5,717,000 | 0.54% | ||
| 36 | Bank of New York Mellon Corp | 773,952 | 5,704,000 | 0.54% | ||
| 37 | EcoR1 Capital, LLC | 7,350 | 5,417,000 | 0.51% | Call | |
| 38 | STATE OF WISCONSIN INVESTMENT BOARD | 700,000 | 5,159,000 | 0.49% | ||
| 39 | PANAGORA ASSET MANAGEMENT INC | 623,011 | 4,591,000 | 0.44% | ||
| 40 | TFS CAPITAL LLC | 602,451 | 4,440,000 | 0.42% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 564,210 | 4,158,000 | 0.39% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 463,300 | 3,415,000 | 0.32% | Call | |
| 43 | PRINCIPAL FINANCIAL GROUP INC | 461,054 | 3,398,000 | 0.32% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 445,050 | 3,281,000 | 0.31% | ||
| 45 | BlackRock Investment Management, LLC | 418,251 | 3,083,000 | 0.29% | ||
| 46 | Rhenman & Partners Asset Management AB | 400,000 | 2,948,000 | 0.28% | ||
| 47 | KOPP INVESTMENT ADVISORS LLC | 381,197 | 2,809,000 | 0.27% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 2,487,000 | 0.24% | ||
| 49 | TD ASSET MANAGEMENT INC | 330,400 | 2,435,000 | 0.23% | ||
| 50 | CITADEL ADVISORS LLC | 294,117 | 2,167,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
