| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 13,876,513 | 49,539,000 | 11.80% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 12,205,673 | 43,574,000 | 10.38% | ||
| 3 | FMR LLC | 11,452,470 | 40,885,000 | 9.74% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,829,600 | 31,522,000 | 7.51% | ||
| 5 | Redmile Group, LLC | 8,342,045 | 29,781,000 | 7.09% | ||
| 6 | ORBIMED ADVISORS LLC | 6,402,800 | 22,858,000 | 5.44% | ||
| 7 | STATE STREET CORP | 6,333,937 | 22,608,000 | 5.38% | ||
| 8 | BlackRock Fund Advisors | 4,646,266 | 16,587,000 | 3.95% | ||
| 9 | VANGUARD GROUP INC | 3,951,271 | 14,106,000 | 3.36% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,947,943 | 14,094,000 | 3.36% | ||
| 11 | TimesSquare Capital Management, LLC | 3,939,850 | 14,065,000 | 3.35% | ||
| 12 | APEX CAPITAL, LLC | 3,100,100 | 11,067,000 | 2.64% | ||
| 13 | Artal Group S.A. | 3,000,000 | 10,710,000 | 2.55% | ||
| 14 | QVT Financial LP | 2,391,200 | 8,537,000 | 2.03% | ||
| 15 | KOPP INVESTMENT ADVISORS LLC | 2,005,410 | 7,160,000 | 1.71% | ||
| 16 | BAKER BROS. ADVISORS LP | 1,433,797 | 5,119,000 | 1.22% | ||
| 17 | NORTHERN TRUST CORP | 1,432,182 | 5,113,000 | 1.22% | ||
| 18 | Point72 Asset Management, L.P. | 1,425,300 | 5,088,000 | 1.21% | ||
| 19 | DEUTSCHE BANK AG\ | 1,424,464 | 5,081,000 | 1.21% | ||
| 20 | BLACKROCK ADVISORS LLC | 1,259,176 | 4,495,000 | 1.07% | ||
| 21 | First Light Asset Management, LLC | 1,059,270 | 3,782,000 | 0.90% | ||
| 22 | Cormorant Asset Management, LP | 1,000,000 | 3,570,000 | 0.85% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 873,922 | 3,120,000 | 0.74% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 757,378 | 2,704,000 | 0.64% | ||
| 25 | Bank of New York Mellon Corp | 688,097 | 2,456,000 | 0.58% | ||
| 26 | CITY NATIONAL BANK | 687,013 | 2,453,000 | 0.58% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 647,452 | 2,311,000 | 0.55% | ||
| 28 | PRINCIPAL FINANCIAL GROUP INC | 608,467 | 2,173,000 | 0.52% | ||
| 29 | PANAGORA ASSET MANAGEMENT INC | 590,128 | 2,107,000 | 0.50% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 580,949 | 2,073,000 | 0.49% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 476,825 | 1,702,000 | 0.41% | ||
| 32 | BlackRock Group LTD | 435,512 | 1,555,000 | 0.37% | ||
| 33 | CAPITAL GUARDIAN TRUST CO | 435,000 | 1,553,000 | 0.37% | ||
| 34 | Rhenman & Partners Asset Management AB | 379,199 | 1,354,000 | 0.32% | ||
| 35 | BlackRock Investment Management, LLC | 379,016 | 1,353,000 | 0.32% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 338,633 | 1,209,000 | 0.29% | ||
| 37 | TD ASSET MANAGEMENT INC | 327,300 | 1,168,000 | 0.28% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 1,162,000 | 0.28% | ||
| 39 | GOLDMAN SACHS GROUP INC | 308,759 | 1,102,000 | 0.26% | ||
| 40 | BlackRock Finance, Inc. | 292,035 | 1,043,000 | 0.25% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 274,200 | 979,000 | 0.23% | Call | |
| 42 | GROUP ONE TRADING LLC | 268,332 | 958,000 | 0.23% | ||
| 43 | State of New Jersey Common Pension Fund D | 265,000 | 946,000 | 0.23% | ||
| 44 | MORGAN STANLEY | 244,473 | 872,000 | 0.21% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 232,602 | 830,000 | 0.20% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 213,455 | 762,000 | 0.18% | ||
| 47 | Weiss Multi-Strategy Advisers LLC | 205,000 | 732,000 | 0.17% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 203,519 | 727,000 | 0.17% | ||
| 49 | WELLS FARGO & COMPANY/MN | 198,980 | 711,000 | 0.17% | ||
| 50 | PUTNAM INVESTMENTS LLC | 194,707 | 695,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
