| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Redmile Group, LLC | 11,858,294 | 56,090,000 | 9.75% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 11,834,595 | 55,978,000 | 9.73% | ||
| 3 | BVF INC/IL | 11,772,335 | 55,683,000 | 9.68% | ||
| 4 | FMR LLC | 11,225,970 | 53,099,000 | 9.23% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,693,100 | 41,118,000 | 7.15% | ||
| 6 | ORBIMED ADVISORS LLC | 7,247,700 | 34,282,000 | 5.96% | ||
| 7 | BlackRock Fund Advisors | 5,079,429 | 24,026,000 | 4.18% | ||
| 8 | STATE STREET CORP | 4,841,504 | 22,899,000 | 3.98% | ||
| 9 | VANGUARD GROUP INC | 4,387,269 | 20,751,000 | 3.61% | ||
| 10 | TimesSquare Capital Management, LLC | 4,092,450 | 19,357,000 | 3.36% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,971,863 | 18,787,000 | 3.27% | ||
| 12 | Artal Group S.A. | 3,000,000 | 14,190,000 | 2.47% | ||
| 13 | APEX CAPITAL, LLC | 2,002,700 | 9,473,000 | 1.65% | ||
| 14 | BAKER BROS. ADVISORS LP | 1,433,797 | 6,782,000 | 1.18% | ||
| 15 | NORTHERN TRUST CORP | 1,380,400 | 6,529,000 | 1.13% | ||
| 16 | DEUTSCHE BANK AG\ | 1,363,217 | 6,446,000 | 1.12% | ||
| 17 | FIRST MANHATTAN CO. LLC. | 1,300,000 | 6,149,000 | 1.07% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 1,292,428 | 6,113,000 | 1.06% | ||
| 19 | BLACKROCK ADVISORS LLC | 1,250,851 | 5,916,000 | 1.03% | ||
| 20 | First Light Asset Management, LLC | 1,129,560 | 5,343,000 | 0.93% | ||
| 21 | Cormorant Asset Management, LP | 1,000,000 | 4,730,000 | 0.82% | ||
| 22 | STATE OF WISCONSIN INVESTMENT BOARD | 1,000,000 | 4,730,000 | 0.82% | ||
| 23 | SPHERA FUNDS MANAGEMENT LTD. | 973,922 | 4,607,000 | 0.80% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 905,205 | 4,282,000 | 0.74% | ||
| 25 | Point72 Asset Management, L.P. | 903,300 | 4,273,000 | 0.74% | ||
| 26 | AXA S.A. | 854,606 | 4,042,000 | 0.70% | ||
| 27 | CITY NATIONAL BANK | 743,477 | 3,516,000 | 0.61% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 695,843 | 3,291,000 | 0.57% | ||
| 29 | Bank of New York Mellon Corp | 692,641 | 3,276,000 | 0.57% | ||
| 30 | KENNEDY CAPITAL MANAGEMENT LLC | 663,662 | 3,139,000 | 0.55% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 642,900 | 3,041,000 | 0.53% | Put | |
| 32 | PANAGORA ASSET MANAGEMENT INC | 621,867 | 2,941,000 | 0.51% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 610,177 | 2,887,000 | 0.50% | ||
| 34 | KOPP INVESTMENT ADVISORS LLC | 600,057 | 2,838,000 | 0.49% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 576,788 | 2,728,000 | 0.47% | ||
| 36 | Rhenman & Partners Asset Management AB | 545,000 | 2,578,000 | 0.45% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 2,487,000 | 0.43% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 463,916 | 2,194,000 | 0.38% | ||
| 39 | BlackRock Group LTD | 443,438 | 2,097,000 | 0.36% | ||
| 40 | BlackRock Investment Management, LLC | 371,942 | 1,759,000 | 0.31% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 362,119 | 1,713,000 | 0.30% | ||
| 42 | QVT Financial LP | 361,722 | 1,711,000 | 0.30% | ||
| 43 | D. E. Shaw & Co., Inc. | 355,069 | 1,679,000 | 0.29% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 346,197 | 1,638,000 | 0.28% | ||
| 45 | TD ASSET MANAGEMENT INC | 339,700 | 1,607,000 | 0.28% | ||
| 46 | Artal Group S.A. | 310,000 | 1,466,000 | 0.25% | Call | |
| 47 | CAPITAL GUARDIAN TRUST CO | 200,000 | 1,432,000 | 0.25% | ||
| 48 | BlackRock Finance, Inc. | 292,035 | 1,381,000 | 0.24% | ||
| 49 | CREDIT SUISSE AG/ | 267,170 | 1,264,000 | 0.22% | ||
| 50 | State of New Jersey Common Pension Fund D | 265,000 | 1,253,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
