| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,663,391 | 85,105,000 | 13.12% | ||
| 2 | Redmile Group, LLC | 17,750,510 | 80,942,000 | 12.48% | ||
| 3 | ORBIMED ADVISORS LLC | 10,060,500 | 45,876,000 | 7.07% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 9,729,361 | 44,366,000 | 6.84% | ||
| 5 | BVF INC/IL | 9,680,630 | 44,144,000 | 6.81% | ||
| 6 | VANGUARD GROUP INC | 7,539,581 | 34,382,000 | 5.30% | ||
| 7 | STATE STREET CORP | 6,461,332 | 29,466,000 | 4.54% | ||
| 8 | BlackRock Fund Advisors | 5,346,211 | 24,379,000 | 3.76% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,142,725 | 23,451,000 | 3.62% | ||
| 10 | BAKER BROS. ADVISORS LP | 4,310,666 | 19,657,000 | 3.03% | ||
| 11 | Artal Group S.A. | 3,710,000 | 16,918,000 | 2.61% | ||
| 12 | TimesSquare Capital Management, LLC | 3,639,989 | 16,598,000 | 2.56% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 3,375,599 | 15,393,000 | 2.37% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 2,632,022 | 12,002,000 | 1.85% | ||
| 15 | Invesco Ltd. | 2,305,104 | 10,511,000 | 1.62% | ||
| 16 | DEUTSCHE BANK AG\ | 2,041,593 | 9,306,000 | 1.43% | ||
| 17 | NORTHERN TRUST CORP | 1,559,701 | 7,112,000 | 1.10% | ||
| 18 | STATE OF WISCONSIN INVESTMENT BOARD | 1,250,000 | 5,700,000 | 0.88% | ||
| 19 | FIRST MANHATTAN CO. LLC. | 1,196,500 | 5,456,000 | 0.84% | ||
| 20 | GOLDMAN SACHS GROUP INC | 1,075,214 | 4,903,000 | 0.76% | ||
| 21 | First Light Asset Management, LLC | 988,589 | 4,508,000 | 0.69% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 929,428 | 4,238,000 | 0.65% | ||
| 23 | COLUMBUS CIRCLE INVESTORS | 912,908 | 4,163,000 | 0.64% | ||
| 24 | AXA S.A. | 900,497 | 4,106,000 | 0.63% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 866,247 | 3,950,000 | 0.61% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 865,900 | 3,949,000 | 0.61% | Put | |
| 27 | Cormorant Asset Management, LP | 850,000 | 3,876,000 | 0.60% | ||
| 28 | Connor, Clark & Lunn Investment Management Ltd. | 734,700 | 3,350,000 | 0.52% | ||
| 29 | PANAGORA ASSET MANAGEMENT INC | 731,071 | 3,333,000 | 0.51% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 671,500 | 3,062,000 | 0.47% | Call | |
| 31 | Bank of New York Mellon Corp | 652,685 | 2,976,000 | 0.46% | ||
| 32 | WELLINGTON MANAGEMENT GROUP LLP | 549,798 | 2,507,000 | 0.39% | ||
| 33 | PRINCIPAL FINANCIAL GROUP INC | 516,274 | 2,354,000 | 0.36% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 509,437 | 2,324,000 | 0.36% | ||
| 35 | ACUTA CAPITAL PARTNERS, LLC | 480,020 | 2,189,000 | 0.34% | ||
| 36 | BlackRock Investment Management, LLC | 479,668 | 2,187,000 | 0.34% | ||
| 37 | GOLDMAN SACHS GROUP INC | 467,500 | 2,132,000 | 0.33% | Put | |
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 464,394 | 2,118,000 | 0.33% | ||
| 39 | TWO SIGMA ADVISERS, LP | 391,513 | 1,874,000 | 0.29% | ||
| 40 | KOPP INVESTMENT ADVISORS LLC | 381,777 | 1,741,000 | 0.27% | ||
| 41 | Rhenman & Partners Asset Management AB | 370,000 | 1,687,000 | 0.26% | ||
| 42 | SPHERA FUNDS MANAGEMENT LTD. | 350,000 | 1,596,000 | 0.25% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 1,484,000 | 0.23% | ||
| 44 | AMERICAN CENTURY COMPANIES INC | 311,468 | 1,420,000 | 0.22% | ||
| 45 | Artal Group S.A. | 300,000 | 1,368,000 | 0.21% | Call | |
| 46 | WELLS FARGO & COMPANY/MN | 284,586 | 1,297,000 | 0.20% | ||
| 47 | Rotella Capital Management, Inc. | 275,600 | 1,257,000 | 0.19% | ||
| 48 | State of New Jersey Common Pension Fund D | 265,000 | 1,208,000 | 0.19% | ||
| 49 | Bluefin Trading, LLC | 263,043 | 1,199,000 | 0.18% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 256,731 | 1,171,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
