| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,680,097 | 78,830,000 | 13.68% | ||
| 2 | Redmile Group, LLC | 17,850,650 | 75,330,000 | 13.08% | ||
| 3 | ORBIMED ADVISORS LLC | 10,689,000 | 45,108,000 | 7.83% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 8,729,361 | 36,838,000 | 6.39% | ||
| 5 | VANGUARD GROUP INC | 8,010,795 | 33,805,000 | 5.87% | ||
| 6 | BVF INC/IL | 6,682,711 | 28,201,000 | 4.90% | ||
| 7 | BlackRock Fund Advisors | 5,100,339 | 21,523,000 | 3.74% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 5,073,989 | 21,412,000 | 3.72% | ||
| 9 | STATE STREET CORP | 4,809,038 | 20,294,000 | 3.52% | ||
| 10 | BAKER BROS. ADVISORS LP | 4,310,666 | 18,191,000 | 3.16% | ||
| 11 | Artal Group S.A. | 3,710,000 | 15,656,000 | 2.72% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,424,911 | 14,453,000 | 2.51% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 3,210,394 | 13,548,000 | 2.35% | ||
| 14 | DEUTSCHE BANK AG\ | 2,754,067 | 11,620,000 | 2.02% | ||
| 15 | Visium Asset Management, LP | 2,000,000 | 8,440,000 | 1.46% | ||
| 16 | AXA S.A. | 1,783,123 | 7,525,000 | 1.31% | ||
| 17 | NORTHERN TRUST CORP | 1,597,625 | 6,742,000 | 1.17% | ||
| 18 | TEACHERS ADVISORS, LLC | 1,250,688 | 5,278,000 | 0.92% | ||
| 19 | FIRST MANHATTAN CO. LLC. | 1,099,801 | 4,641,000 | 0.81% | ||
| 20 | OXFORD ASSET MANAGEMENT LLP | 1,064,085 | 4,459,000 | 0.77% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 1,036,436 | 4,373,000 | 0.76% | ||
| 22 | Point72 Asset Management, L.P. | 952,200 | 4,018,000 | 0.70% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 920,900 | 3,886,000 | 0.67% | Call | |
| 24 | PANAGORA ASSET MANAGEMENT INC | 781,451 | 3,298,000 | 0.57% | ||
| 25 | STATE OF WISCONSIN INVESTMENT BOARD | 750,000 | 3,165,000 | 0.55% | ||
| 26 | Sarissa Capital Management LP | 700,000 | 2,954,000 | 0.51% | ||
| 27 | COLUMBUS CIRCLE INVESTORS | 697,122 | 2,942,000 | 0.51% | ||
| 28 | GOLDMAN SACHS GROUP INC | 689,070 | 2,907,000 | 0.50% | ||
| 29 | Parallax Volatility Advisers, L.P. | 630,000 | 2,659,000 | 0.46% | Put | |
| 30 | Bank of New York Mellon Corp | 625,866 | 2,641,000 | 0.46% | ||
| 31 | RUBRIC CAPITAL MANAGEMENT, LLC | 600,000 | 2,532,000 | 0.44% | ||
| 32 | Parallax Volatility Advisers, L.P. | 590,442 | 2,492,000 | 0.43% | ||
| 33 | A.R.T. Advisors, LLC | 544,368 | 2,297,000 | 0.40% | ||
| 34 | First Light Asset Management, LLC | 530,391 | 2,238,000 | 0.39% | ||
| 35 | Connor, Clark & Lunn Investment Management Ltd. | 522,100 | 2,203,000 | 0.38% | ||
| 36 | PRINCIPAL FINANCIAL GROUP INC | 516,260 | 2,179,000 | 0.38% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497,245 | 2,099,000 | 0.36% | ||
| 38 | BlackRock Investment Management, LLC | 479,611 | 2,024,000 | 0.35% | ||
| 39 | CITADEL ADVISORS LLC | 453,393 | 1,913,000 | 0.33% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 450,291 | 1,900,000 | 0.33% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 442,400 | 1,867,000 | 0.32% | Put | |
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 382,318 | 1,614,000 | 0.28% | ||
| 43 | KOPP INVESTMENT ADVISORS LLC | 376,477 | 1,589,000 | 0.28% | ||
| 44 | TWO SIGMA ADVISERS, LP | 372,313 | 1,571,000 | 0.27% | ||
| 45 | Rhenman & Partners Asset Management AB | 370,000 | 1,561,000 | 0.27% | ||
| 46 | WELLS FARGO & COMPANY/MN | 332,096 | 1,401,000 | 0.24% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 1,374,000 | 0.24% | ||
| 48 | GOLDMAN SACHS GROUP INC | 306,400 | 1,293,000 | 0.22% | Put | |
| 49 | UBS Group AG | 302,515 | 1,277,000 | 0.22% | ||
| 50 | Artal Group S.A. | 300,000 | 1,266,000 | 0.22% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
