| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,468,470 | 58,602,000 | 11.25% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 12,205,673 | 57,367,000 | 11.01% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,969,900 | 42,159,000 | 8.09% | ||
| 4 | BVF INC/IL | 8,486,927 | 39,889,000 | 7.66% | ||
| 5 | ORBIMED ADVISORS LLC | 6,297,000 | 29,596,000 | 5.68% | ||
| 6 | STATE STREET CORP | 5,516,395 | 25,928,000 | 4.98% | ||
| 7 | BlackRock Fund Advisors | 4,993,088 | 23,468,000 | 4.50% | ||
| 8 | Redmile Group, LLC | 4,882,930 | 22,950,000 | 4.40% | ||
| 9 | TimesSquare Capital Management, LLC | 3,927,500 | 18,459,000 | 3.54% | ||
| 10 | VANGUARD GROUP INC | 3,907,120 | 18,364,000 | 3.52% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,753,233 | 17,640,000 | 3.39% | ||
| 12 | Artal Group S.A. | 3,000,000 | 14,100,000 | 2.71% | ||
| 13 | APEX CAPITAL, LLC | 2,400,000 | 11,280,000 | 2.16% | ||
| 14 | QVT Financial LP | 2,256,200 | 10,604,000 | 2.04% | ||
| 15 | KOPP INVESTMENT ADVISORS LLC | 2,201,265 | 10,346,000 | 1.99% | ||
| 16 | BALYASNY ASSET MANAGEMENT L.P. | 2,070,626 | 9,732,000 | 1.87% | ||
| 17 | Cormorant Asset Management, LP | 1,750,000 | 8,225,000 | 1.58% | ||
| 18 | BLACKROCK ADVISORS LLC | 1,710,264 | 8,038,000 | 1.54% | ||
| 19 | NORTHERN TRUST CORP | 1,592,726 | 7,486,000 | 1.44% | ||
| 20 | BAKER BROS. ADVISORS LP | 1,433,797 | 6,739,000 | 1.29% | ||
| 21 | DEUTSCHE BANK AG\ | 1,324,956 | 6,226,000 | 1.19% | ||
| 22 | First Light Asset Management, LLC | 976,799 | 4,591,000 | 0.88% | ||
| 23 | TEACHERS ADVISORS, LLC | 819,582 | 3,852,000 | 0.74% | ||
| 24 | PRINCIPAL FINANCIAL GROUP INC | 788,680 | 3,707,000 | 0.71% | ||
| 25 | Bank of New York Mellon Corp | 652,581 | 3,067,000 | 0.59% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 570,956 | 2,683,000 | 0.51% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 563,781 | 2,649,000 | 0.51% | ||
| 28 | COLUMBUS CIRCLE INVESTORS | 483,751 | 2,274,000 | 0.44% | ||
| 29 | SUFFOLK CAPITAL MANAGEMENT LLC | 479,113 | 2,252,000 | 0.43% | ||
| 30 | CAPITAL GUARDIAN TRUST CO | 475,000 | 2,233,000 | 0.43% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 471,374 | 2,215,000 | 0.43% | ||
| 32 | BlackRock Group LTD | 435,512 | 2,046,000 | 0.39% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 412,031 | 1,937,000 | 0.37% | ||
| 34 | TD ASSET MANAGEMENT INC | 362,300 | 1,703,000 | 0.33% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 343,600 | 1,615,000 | 0.31% | Put | |
| 36 | BlackRock Investment Management, LLC | 343,080 | 1,612,000 | 0.31% | ||
| 37 | GOLDMAN SACHS GROUP INC | 342,498 | 1,610,000 | 0.31% | ||
| 38 | Rhenman & Partners Asset Management AB | 329,199 | 1,547,000 | 0.30% | ||
| 39 | CITY NATIONAL BANK | 315,830 | 1,485,000 | 0.29% | ||
| 40 | BlackRock Finance, Inc. | 315,334 | 1,482,000 | 0.28% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 310,859 | 1,462,000 | 0.28% | ||
| 42 | GROUP ONE TRADING LLC | 307,577 | 1,446,000 | 0.28% | ||
| 43 | Opaleye Management Inc. | 305,000 | 1,434,000 | 0.28% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 325,500 | 1,380,000 | 0.26% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 283,164 | 1,331,000 | 0.26% | ||
| 46 | State of New Jersey Common Pension Fund A | 265,000 | 1,246,000 | 0.24% | ||
| 47 | Allianz Asset Management GmbH | 237,602 | 1,117,000 | 0.21% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 223,982 | 1,053,000 | 0.20% | ||
| 49 | ProShare Advisors LLC | 221,262 | 1,040,000 | 0.20% | ||
| 50 | WELLS FARGO & COMPANY/MN | 209,858 | 986,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
