| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 24,513,384 | 165,465,000 | 16.47% | ||
| 2 | Redmile Group, LLC | 16,658,072 | 112,442,000 | 11.19% | ||
| 3 | ORBIMED ADVISORS LLC | 14,179,900 | 95,714,000 | 9.53% | ||
| 4 | VANGUARD GROUP INC | 9,764,687 | 65,911,000 | 6.56% | ||
| 5 | BVF INC/IL | 6,461,186 | 43,613,000 | 4.34% | ||
| 6 | BlackRock Fund Advisors | 5,623,151 | 37,956,000 | 3.78% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 5,488,810 | 37,049,000 | 3.69% | ||
| 8 | STATE STREET CORP | 4,544,479 | 30,679,000 | 3.05% | ||
| 9 | FRANKLIN RESOURCES INC | 4,331,100 | 29,235,000 | 2.91% | ||
| 10 | Sarissa Capital Management LP | 4,300,000 | 29,025,000 | 2.89% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,730,517 | 25,181,000 | 2.51% | ||
| 12 | Artal Group S.A. | 3,500,000 | 23,625,000 | 2.35% | ||
| 13 | BAKER BROS. ADVISORS LP | 3,310,666 | 22,347,000 | 2.22% | ||
| 14 | DEUTSCHE BANK AG\ | 2,760,731 | 18,632,000 | 1.85% | ||
| 15 | TEACHERS ADVISORS, LLC | 1,978,792 | 13,357,000 | 1.33% | ||
| 16 | Invesco Ltd. | 1,925,674 | 12,998,000 | 1.29% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,650,000 | 11,138,000 | 1.11% | ||
| 18 | NORTHERN TRUST CORP | 1,569,083 | 10,592,000 | 1.05% | ||
| 19 | BSW Wealth Partners | 68 | 10,000,000 | 1.00% | ||
| 20 | PANAGORA ASSET MANAGEMENT INC | 1,393,296 | 9,405,000 | 0.94% | ||
| 21 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 1,277,214 | 8,621,000 | 0.86% | ||
| 22 | Cormorant Asset Management, LP | 1,150,000 | 7,763,000 | 0.77% | ||
| 23 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,060,183 | 7,156,000 | 0.71% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 989,970 | 6,682,000 | 0.66% | ||
| 25 | First Light Asset Management, LLC | 986,242 | 6,657,000 | 0.66% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 953,180 | 6,433,000 | 0.64% | ||
| 27 | CITADEL ADVISORS LLC | 917,065 | 6,190,000 | 0.62% | ||
| 28 | SPHERA FUNDS MANAGEMENT LTD. | 900,000 | 6,075,000 | 0.60% | ||
| 29 | Spark Investment Management LLC | 877,800 | 5,925,000 | 0.59% | ||
| 30 | AXA S.A. | 863,674 | 5,830,000 | 0.58% | ||
| 31 | Candriam S.C.A. | 810,000 | 5,468,000 | 0.54% | ||
| 32 | DRIEHAUS CAPITAL MANAGEMENT LLC | 783,744 | 5,290,000 | 0.53% | ||
| 33 | SENZAR ASSET MANAGEMENT, LLC | 627,100 | 4,232,925 | 0.42% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 624,244 | 4,214,000 | 0.42% | ||
| 35 | BlackRock Investment Management, LLC | 595,435 | 4,019,000 | 0.40% | ||
| 36 | Bank of New York Mellon Corp | 583,377 | 3,938,000 | 0.39% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 559,800 | 3,779,000 | 0.38% | Call | |
| 38 | Rhenman & Partners Asset Management AB | 550,000 | 3,712,500 | 0.37% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 546,147 | 3,687,000 | 0.37% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 497,611 | 3,359,000 | 0.33% | ||
| 41 | CHICAGO EQUITY PARTNERS LLC | 485,780 | 3,279,000 | 0.33% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 450,229 | 3,039,000 | 0.30% | ||
| 43 | RENAISSANCE TECHNOLOGIES LLC | 424,452 | 2,865,000 | 0.29% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 400,000 | 2,700,000 | 0.27% | Put | |
| 45 | GOLDMAN SACHS GROUP INC | 340,072 | 2,295,000 | 0.23% | ||
| 46 | MACQUARIE GROUP LTD | 330,000 | 2,228,000 | 0.22% | ||
| 47 | KOPP INVESTMENT ADVISORS LLC | 329,282 | 2,223,000 | 0.22% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 305,901 | 2,065,000 | 0.21% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 278,500 | 1,880,000 | 0.19% | ||
| 50 | State of New Jersey Common Pension Fund D | 265,000 | 1,789,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
