| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Redmile Group, LLC | 19,150,650 | 56,494,000 | 14.81% | ||
| 2 | FMR LLC | 13,411,691 | 39,564,000 | 10.37% | ||
| 3 | ORBIMED ADVISORS LLC | 10,689,000 | 31,533,000 | 8.27% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 9,529,361 | 28,112,000 | 7.37% | ||
| 5 | VANGUARD GROUP INC | 8,377,991 | 24,716,000 | 6.48% | ||
| 6 | BVF INC/IL | 7,850,211 | 23,158,000 | 6.07% | ||
| 7 | BlackRock Fund Advisors | 5,199,679 | 15,339,000 | 4.02% | ||
| 8 | STATE STREET CORP | 4,812,664 | 14,196,000 | 3.72% | ||
| 9 | BAKER BROS. ADVISORS LP | 4,310,666 | 12,716,000 | 3.33% | ||
| 10 | Artal Group S.A. | 3,710,000 | 10,945,000 | 2.87% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,441,224 | 10,152,000 | 2.66% | ||
| 12 | Sarissa Capital Management LP | 2,875,000 | 8,481,000 | 2.22% | ||
| 13 | DEUTSCHE BANK AG\ | 2,702,026 | 7,968,000 | 2.09% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 2,154,652 | 6,356,000 | 1.67% | ||
| 15 | ARMISTICE CAPITAL, LLC | 2,000,000 | 5,900,000 | 1.55% | ||
| 16 | TEACHERS ADVISORS, LLC | 1,914,146 | 5,647,000 | 1.48% | ||
| 17 | AXA S.A. | 1,754,773 | 5,177,000 | 1.36% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 1,676,754 | 4,946,000 | 1.30% | ||
| 19 | NORTHERN TRUST CORP | 1,624,629 | 4,793,000 | 1.26% | ||
| 20 | Visium Asset Management, LP | 1,525,000 | 4,499,000 | 1.18% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 1,366,105 | 4,030,000 | 1.06% | ||
| 22 | Parallax Volatility Advisers, L.P. | 1,097,500 | 3,239,000 | 0.85% | Put | |
| 23 | STATE OF WISCONSIN INVESTMENT BOARD | 900,000 | 2,655,000 | 0.70% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 883,950 | 2,607,000 | 0.68% | ||
| 25 | COLUMBUS CIRCLE INVESTORS | 855,830 | 2,525,000 | 0.66% | ||
| 26 | Parallax Volatility Advisers, L.P. | 771,893 | 2,277,000 | 0.60% | ||
| 27 | Candriam S.C.A. | 659,000 | 1,934,000 | 0.51% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 653,291 | 1,927,000 | 0.51% | ||
| 29 | Bank of New York Mellon Corp | 646,882 | 1,909,000 | 0.50% | ||
| 30 | GOLDMAN SACHS GROUP INC | 568,890 | 1,679,000 | 0.44% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 563,400 | 1,662,000 | 0.44% | Call | |
| 32 | Spark Investment Management LLC | 550,900 | 1,625,000 | 0.43% | ||
| 33 | First Light Asset Management, LLC | 526,270 | 1,552,000 | 0.41% | ||
| 34 | PRINCIPAL FINANCIAL GROUP INC | 513,972 | 1,517,000 | 0.40% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 506,869 | 1,496,000 | 0.39% | ||
| 36 | BlackRock Investment Management, LLC | 487,467 | 1,438,000 | 0.38% | ||
| 37 | KOPP INVESTMENT ADVISORS LLC | 373,857 | 1,103,000 | 0.29% | ||
| 38 | Rhenman & Partners Asset Management AB | 370,000 | 1,092,000 | 0.29% | ||
| 39 | TWO SIGMA ADVISERS, LP | 365,413 | 1,078,000 | 0.28% | ||
| 40 | WELLS FARGO & COMPANY/MN | 363,306 | 1,072,000 | 0.28% | ||
| 41 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 346,400 | 1,022,000 | 0.27% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 307,000 | 906,000 | 0.24% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 298,767 | 881,000 | 0.23% | ||
| 44 | A.R.T. Advisors, LLC | 281,668 | 830,000 | 0.22% | ||
| 45 | LOS ANGELES CAPITAL MANAGEMENT LLC | 273,320 | 806,000 | 0.21% | ||
| 46 | State of New Jersey Common Pension Fund D | 265,000 | 782,000 | 0.20% | ||
| 47 | Spot Trading L.L.C | 255,600 | 754,000 | 0.20% | Call | |
| 48 | Weiss Multi-Strategy Advisers LLC | 240,000 | 708,000 | 0.19% | ||
| 49 | Swiss National Bank | 234,800 | 669,000 | 0.18% | ||
| 50 | CREDIT SUISSE AG/ | 226,029 | 667,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
