| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 19,622,890 | 164,243,000 | 11.52% | ||
| 2 | FMR LLC | 18,532,336 | 155,116,000 | 10.88% | ||
| 3 | Redmile Group, LLC | 16,093,786 | 134,705,000 | 9.45% | ||
| 4 | ORBIMED ADVISORS LLC | 14,182,900 | 118,711,000 | 8.33% | ||
| 5 | BlackRock Finance, Inc. | 12,994,700 | 108,765,000 | 7.63% | ||
| 6 | STATE STREET CORP | 9,544,525 | 79,890,000 | 5.61% | ||
| 7 | FRANKLIN RESOURCES INC | 8,950,982 | 74,920,000 | 5.26% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 6,604,997 | 55,284,000 | 3.88% | ||
| 9 | BVF INC/IL | 6,059,625 | 50,719,000 | 3.56% | ||
| 10 | Avoro Capital Advisors LLC | 4,175,376 | 34,948,000 | 2.45% | ||
| 11 | MORGAN STANLEY | 2,495,329 | 20,886,000 | 1.47% | ||
| 12 | Point72 Asset Management, L.P. | 2,406,000 | 20,138,000 | 1.41% | ||
| 13 | NORTHERN TRUST CORP | 2,130,493 | 17,832,000 | 1.25% | ||
| 14 | DEUTSCHE BANK AG\ | 2,031,823 | 17,003,000 | 1.19% | ||
| 15 | Invesco Ltd. | 1,892,728 | 15,842,000 | 1.11% | ||
| 16 | BAKER BROS. ADVISORS LP | 1,585,913 | 13,274,000 | 0.93% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 1,499,178 | 12,548,000 | 0.88% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,446,775 | 12,109,000 | 0.85% | ||
| 19 | NORGES BANK | 1,373,168 | 11,493,000 | 0.81% | ||
| 20 | TEACHERS ADVISORS, LLC | 1,274,728 | 10,669,000 | 0.75% | ||
| 21 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,254,344 | 10,499,000 | 0.74% | ||
| 22 | PANAGORA ASSET MANAGEMENT INC | 1,232,511 | 10,316,000 | 0.72% | ||
| 23 | CAMBIAR INVESTORS LLC | 1,082,875 | 9,064,000 | 0.64% | ||
| 24 | CITADEL ADVISORS LLC | 993,878 | 8,319,000 | 0.58% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 990,441 | 8,290,000 | 0.58% | ||
| 26 | Artal Group S.A. | 950,000 | 7,952,000 | 0.56% | ||
| 27 | Cormorant Asset Management, LP | 900,000 | 7,533,000 | 0.53% | SH | |
| 28 | Bank of New York Mellon Corp | 815,870 | 6,829,000 | 0.48% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 808,800 | 6,770,000 | 0.47% | Put | |
| 30 | PUTNAM INVESTMENTS LLC | 804,009 | 6,730,000 | 0.47% | ||
| 31 | NEXTHERA CAPITAL LP | 800,000 | 6,697,000 | 0.47% | Call | |
| 32 | AXA S.A. | 789,255 | 6,606,000 | 0.46% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 788,992 | 6,603,863 | 0.46% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 731,187 | 6,121,000 | 0.43% | ||
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 719,124 | 6,019,000 | 0.42% | ||
| 36 | SPHERA FUNDS MANAGEMENT LTD. | 700,000 | 5,859,000 | 0.41% | ||
| 37 | MARSHALL WACE NORTH AMERICA, L.P. | 677,109 | 5,417,000 | 0.38% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 581,009 | 4,863,000 | 0.34% | ||
| 39 | First Light Asset Management, LLC | 571,629 | 4,785,000 | 0.34% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 570,182 | 4,772,000 | 0.33% | ||
| 41 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 569,000 | 4,763,000 | 0.33% | ||
| 42 | Artal Group S.A. | 500,000 | 4,185,000 | 0.29% | Call | |
| 43 | HANDELSBANKEN FONDER AB | 480,000 | 4,018,000 | 0.28% | ||
| 44 | Candriam S.C.A. | 465,000 | 3,892,000 | 0.27% | ||
| 45 | PRINCIPAL FINANCIAL GROUP INC | 450,202 | 3,768,000 | 0.26% | ||
| 46 | Quantitative Investment Management, LLC | 443,700 | 3,713,000 | 0.26% | ||
| 47 | Rhenman & Partners Asset Management AB | 425,000 | 3,557,000 | 0.25% | ||
| 48 | WELLINGTON MANAGEMENT GROUP LLP | 420,589 | 3,520,000 | 0.25% | ||
| 49 | CSS LLC/IL | 394,400 | 3,302,000 | 0.23% | Put | |
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 378,500 | 3,168,000 | 0.22% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
