| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,890,872 | 138,859,000 | 20.14% | ||
| 2 | FMR LLC | 10,736,225 | 136,887,000 | 19.85% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 5,349,345 | 68,204,000 | 9.89% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 3,198,529 | 40,781,000 | 5.91% | ||
| 5 | BlackRock Fund Advisors | 2,558,112 | 32,616,000 | 4.73% | ||
| 6 | D. E. Shaw & Co., Inc. | 2,422,218 | 30,883,000 | 4.48% | ||
| 7 | STATE STREET CORP | 2,247,454 | 28,653,000 | 4.16% | ||
| 8 | VANGUARD GROUP INC | 2,049,252 | 26,128,000 | 3.79% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,944,841 | 24,797,000 | 3.60% | ||
| 10 | VHCP Management, LLC | 1,744,356 | 22,241,000 | 3.23% | ||
| 11 | Cormorant Asset Management, LP | 1,168,000 | 14,892,000 | 2.16% | ||
| 12 | QVT Financial LP | 725,734 | 9,253,000 | 1.34% | ||
| 13 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 626,013 | 7,981,000 | 1.16% | ||
| 14 | MORGAN STANLEY | 491,034 | 6,261,000 | 0.91% | ||
| 15 | GOLDMAN SACHS GROUP INC | 369,500 | 4,711,000 | 0.68% | Call | |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 369,040 | 4,705,000 | 0.68% | ||
| 17 | BLACKROCK ADVISORS LLC | 367,890 | 4,691,000 | 0.68% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 355,900 | 4,538,000 | 0.66% | Call | |
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 351,228 | 4,478,000 | 0.65% | ||
| 20 | Bank of New York Mellon Corp | 324,715 | 4,140,000 | 0.60% | ||
| 21 | JENNISON ASSOCIATES LLC | 320,942 | 4,092,000 | 0.59% | ||
| 22 | OXFORD ASSET MANAGEMENT LLP | 293,605 | 3,732,000 | 0.54% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 279,500 | 3,564,000 | 0.52% | Put | |
| 24 | TWO SIGMA INVESTMENTS, LP | 257,889 | 3,288,000 | 0.48% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 249,960 | 3,187,000 | 0.46% | ||
| 26 | NORTHERN TRUST CORP | 238,090 | 3,036,000 | 0.44% | ||
| 27 | BlackRock Investment Management, LLC | 224,551 | 2,863,000 | 0.42% | ||
| 28 | MARSHALL WACE, LLP | 218,413 | 2,785,000 | 0.40% | ||
| 29 | Connor, Clark & Lunn Investment Management Ltd. | 149,398 | 2,029,000 | 0.29% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 148,298 | 1,891,000 | 0.27% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 144,500 | 1,842,000 | 0.27% | ||
| 32 | BlackRock Group LTD | 140,200 | 1,788,000 | 0.26% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 127,900 | 1,631,000 | 0.24% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 112,862 | 1,439,000 | 0.21% | ||
| 35 | Spark Investment Management LLC | 111,900 | 1,425,000 | 0.21% | ||
| 36 | A.R.T. Advisors, LLC | 107,864 | 1,375,000 | 0.20% | ||
| 37 | JANE STREET GROUP, LLC | 106,801 | 1,361,000 | 0.20% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 105,800 | 1,349,000 | 0.20% | ||
| 39 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 103,806 | 1,324,000 | 0.19% | ||
| 40 | PDT Partners, LLC | 100,514 | 1,282,000 | 0.19% | ||
| 41 | TEACHERS ADVISORS, LLC | 98,183 | 1,252,000 | 0.18% | ||
| 42 | CITADEL ADVISORS LLC | 96,068 | 1,224,000 | 0.18% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 93,179 | 1,188,000 | 0.17% | ||
| 44 | Commonwealth Equity Services, Inc | 90,523 | 1,154,000 | 0.17% | ||
| 45 | Informed Momentum Co LLC | 85,721 | 1,093,000 | 0.16% | ||
| 46 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 82,546 | 1,052,000 | 0.15% | ||
| 47 | SABBY MANAGEMENT, LLC | 77,987 | 994,000 | 0.14% | ||
| 48 | ProShare Advisors LLC | 76,608 | 977,000 | 0.14% | ||
| 49 | Swiss National Bank | 74,800 | 954,000 | 0.14% | ||
| 50 | UBS AG | 68,744 | 876,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
