| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,715,462 | 19,945,000 | 24.56% | ||
| 2 | Point72 Asset Management, L.P. | 3,500,000 | 10,395,000 | 12.80% | ||
| 3 | FRANKLIN RESOURCES INC | 2,511,600 | 7,459,000 | 9.18% | ||
| 4 | Broadfin Capital, LLC | 2,400,000 | 7,128,000 | 8.78% | ||
| 5 | VANGUARD GROUP INC | 1,947,849 | 5,785,000 | 7.12% | ||
| 6 | FEDERATED HERMES, INC. | 1,435,000 | 4,262,000 | 5.25% | ||
| 7 | SPHERA FUNDS MANAGEMENT LTD. | 1,060,000 | 3,148,000 | 3.88% | ||
| 8 | Opaleye Management Inc. | 975,000 | 2,896,000 | 3.57% | ||
| 9 | Catalyst Capital Advisors LLC | 955,000 | 2,836,000 | 3.49% | ||
| 10 | Private Capital Advisors, Inc. | 826,500 | 2,455,000 | 3.02% | ||
| 11 | Visium Asset Management, LP | 742,289 | 2,205,000 | 2.71% | ||
| 12 | MORGAN STANLEY | 661,758 | 1,965,000 | 2.42% | ||
| 13 | Avoro Capital Advisors LLC | 550,670 | 1,635,000 | 2.01% | ||
| 14 | TFS CAPITAL LLC | 322,662 | 958,000 | 1.18% | ||
| 15 | PURA VIDA INVESTMENTS, LLC | 315,000 | 936,000 | 1.15% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 265,744 | 789,000 | 0.97% | ||
| 17 | Ghost Tree Capital, LLC | 250,000 | 743,000 | 0.91% | ||
| 18 | DEUTSCHE BANK AG\ | 237,800 | 706,000 | 0.87% | ||
| 19 | AQR CAPITAL MANAGEMENT LLC | 210,882 | 626,000 | 0.77% | ||
| 20 | BlackRock Fund Advisors | 188,458 | 560,000 | 0.69% | ||
| 21 | Weiss Multi-Strategy Advisers LLC | 160,000 | 475,000 | 0.58% | ||
| 22 | TANAKA CAPITAL MANAGEMENT INC | 138,493 | 355,000 | 0.44% | ||
| 23 | NORTHERN TRUST CORP | 96,954 | 288,000 | 0.35% | ||
| 24 | Bank of New York Mellon Corp | 92,241 | 274,000 | 0.34% | ||
| 25 | WELLS FARGO & COMPANY/MN | 91,075 | 270,000 | 0.33% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 85,259 | 253,000 | 0.31% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 66,857 | 199,000 | 0.25% | ||
| 28 | CREDIT SUISSE AG/ | 64,909 | 193,000 | 0.24% | ||
| 29 | Healthcare Value Capital, LLC | 50,000 | 149,000 | 0.18% | ||
| 30 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 48,763 | 145,000 | 0.18% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,332 | 138,000 | 0.17% | ||
| 32 | DIMENSIONAL FUND ADVISORS LP | 46,438 | 138,000 | 0.17% | ||
| 33 | STATE STREET CORP | 44,400 | 133,000 | 0.16% | ||
| 34 | Cowen Prime Services LLC | 43,025 | 128,000 | 0.16% | ||
| 35 | CITADEL ADVISORS LLC | 38,297 | 113,000 | 0.14% | ||
| 36 | A.R.T. Advisors, LLC | 36,042 | 107,000 | 0.13% | ||
| 37 | BlackRock Institutional Trust Company, N.A. | 31,240 | 93,000 | 0.11% | ||
| 38 | Financial Architects, Inc | 30,000 | 89,000 | 0.11% | ||
| 39 | AGRAN LIBBIE | 20,000 | 59,000 | 0.07% | ||
| 40 | GOLDMAN SACHS GROUP INC | 18,702 | 56,000 | 0.07% | ||
| 41 | BLACKROCK ADVISORS LLC | 9,877 | 29,000 | 0.04% | ||
| 42 | BlackRock Investment Management, LLC | 9,799 | 29,000 | 0.04% | ||
| 43 | Creative Planning | 9,351 | 28,000 | 0.03% | ||
| 44 | SIMPLEX TRADING, LLC | 4,087 | 12,000 | 0.01% | ||
| 45 | Stratos Wealth Partners, LTD. | 3,500 | 10,395 | 0.01% | ||
| 46 | Vantage Investment Advisors, LLC | 3,000 | 9,000 | 0.01% | ||
| 47 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 2,000 | 6,000 | 0.01% | ||
| 48 | ROYAL BANK OF CANADA | 2,000 | 6,000 | 0.01% | ||
| 49 | BANK OF MONTREAL /CAN/ | 1,500 | 4,000 | 0.00% | ||
| 50 | UBS Group AG | 300 | 1,000 | 0.00% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
