| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 3,267,000 | 7,384,000 | 31.21% | ||
| 2 | ORBIMED ADVISORS LLC | 1,895,000 | 4,283,000 | 18.10% | ||
| 3 | VANGUARD GROUP INC | 1,634,860 | 3,695,000 | 15.62% | ||
| 4 | Opaleye Management Inc. | 1,378,584 | 3,116,000 | 13.17% | ||
| 5 | BAKER BROS. ADVISORS LP | 569,853 | 1,288,000 | 5.44% | ||
| 6 | SOPHROSYNE CAPITAL LLC | 282,500 | 638,000 | 2.70% | ||
| 7 | AQR CAPITAL MANAGEMENT LLC | 201,282 | 455,000 | 1.92% | ||
| 8 | Ghost Tree Capital, LLC | 200,000 | 452,000 | 1.91% | ||
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 173,788 | 392,000 | 1.66% | ||
| 10 | TANAKA CAPITAL MANAGEMENT INC | 147,993 | 298,000 | 1.26% | ||
| 11 | Bank of New York Mellon Corp | 123,237 | 279,000 | 1.18% | ||
| 12 | Weiss Multi-Strategy Advisers LLC | 100,000 | 226,000 | 0.96% | ||
| 13 | NORTHERN TRUST CORP | 76,786 | 174,000 | 0.74% | ||
| 14 | DEUTSCHE BANK AG\ | 50,000 | 113,000 | 0.48% | ||
| 15 | STATE STREET CORP | 47,200 | 107,000 | 0.45% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 46,438 | 105,000 | 0.44% | ||
| 17 | Cowen Prime Services LLC | 43,550 | 98,000 | 0.41% | ||
| 18 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,332 | 91,000 | 0.38% | ||
| 19 | UBS AG | 32,551 | 74,000 | 0.31% | ||
| 20 | Financial Architects, Inc | 30,000 | 68,000 | 0.29% | ||
| 21 | Cetera Advisor Networks LLC | 24,000 | 54,000 | 0.23% | ||
| 22 | GUGGENHEIM CAPITAL LLC | 19,518 | 44,000 | 0.19% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 17,600 | 40,000 | 0.17% | ||
| 24 | GROUP ONE TRADING LLC | 12,676 | 29,000 | 0.12% | ||
| 25 | Rotella Capital Management, Inc. | 12,300 | 28,000 | 0.12% | ||
| 26 | Quantitative Investment Management, LLC | 11,500 | 25,000 | 0.11% | ||
| 27 | Janney Montgomery Scott LLC | 10,000 | 22,600 | 0.10% | ||
| 28 | Creative Planning | 8,231 | 19,000 | 0.08% | ||
| 29 | CITADEL ADVISORS LLC | 7,599 | 17,000 | 0.07% | ||
| 30 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 5,500 | 12,000 | 0.05% | ||
| 31 | Vantage Investment Advisors, LLC | 3,000 | 7,000 | 0.03% | ||
| 32 | MORGAN STANLEY | 3,161 | 7,000 | 0.03% | ||
| 33 | ROYAL BANK OF CANADA | 2,056 | 5,000 | 0.02% | ||
| 34 | AMERICAN INTERNATIONAL GROUP, INC. | 2,000 | 4,520 | 0.02% | ||
| 35 | UBS AG | 1,200 | 3,000 | 0.01% | Call | |
| 36 | BANK OF MONTREAL /CAN/ | 1,500 | 3,000 | 0.01% | ||
| 37 | UBS AG | 1,400 | 3,000 | 0.01% | Put | |
| 38 | ALLIANCEBERNSTEIN L.P. | 364 | 1,000 | 0.00% | ||
| 39 | Tower Research Capital LLC (TRC) | 534 | 1,000 | 0.00% | ||
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 601 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
