| 1 |
BAKER BROS. ADVISORS LP |
7,335,692 |
30,296,000 |
16.82% |
|
|
| 2 |
Consonance Capital Management LP |
5,517,885 |
22,789,000 |
12.65% |
|
|
| 3 |
FEDERATED HERMES, INC. |
4,563,800 |
18,848,000 |
10.46% |
|
|
| 4 |
Broadfin Capital, LLC |
4,183,177 |
17,277,000 |
9.59% |
|
|
| 5 |
Point72 Asset Management, L.P. |
3,463,805 |
14,306,000 |
7.94% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
2,511,600 |
10,373,000 |
5.76% |
|
|
| 7 |
VANGUARD GROUP INC |
2,397,138 |
9,900,000 |
5.50% |
|
|
| 8 |
BlackRock Fund Advisors |
1,976,992 |
8,165,000 |
4.53% |
|
|
| 9 |
Catalyst Capital Advisors LLC |
1,310,000 |
5,411,000 |
3.00% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
1,200,000 |
4,956,000 |
2.75% |
|
|
| 11 |
PERCEPTIVE ADVISORS LLC |
851,200 |
3,515,000 |
1.95% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
717,154 |
2,962,000 |
1.64% |
|
|
| 13 |
STATE STREET CORP |
661,259 |
2,731,000 |
1.52% |
|
|
| 14 |
PURA VIDA INVESTMENTS, LLC |
395,000 |
1,951,000 |
1.08% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
407,987 |
1,684,000 |
0.93% |
|
|
| 16 |
Allianz Asset Management GmbH |
407,019 |
1,681,000 |
0.93% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
405,901 |
1,675,000 |
0.93% |
|
|
| 18 |
HealthCor Management, L.P. |
385,500 |
1,592,000 |
0.88% |
|
|
| 19 |
MORGAN STANLEY |
370,513 |
1,531,000 |
0.85% |
|
|
| 20 |
Bank of New York Mellon Corp |
310,422 |
1,282,000 |
0.71% |
|
|
| 21 |
TURNER INVESTMENTS LLC |
286,370 |
1,183,000 |
0.66% |
|
|
| 22 |
BlackRock Investment Management, LLC |
269,221 |
1,112,000 |
0.62% |
|
|
| 23 |
Informed Momentum Co LLC |
231,051 |
954,000 |
0.53% |
|
|
| 24 |
BLACKROCK ADVISORS LLC |
224,631 |
928,000 |
0.52% |
|
|
| 25 |
COLUMBUS CIRCLE INVESTORS |
208,593 |
861,000 |
0.48% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
206,103 |
851,000 |
0.47% |
|
|
| 27 |
RUSSELL FRANK CO/ |
201,802 |
833,000 |
0.46% |
|
|
| 28 |
AQR CAPITAL MANAGEMENT LLC |
184,782 |
763,000 |
0.42% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
152,198 |
629,000 |
0.35% |
|
|
| 30 |
NORTHERN TRUST CORP |
142,328 |
588,000 |
0.33% |
|
|
| 31 |
Employees Retirement System of Texas |
138,000 |
570,000 |
0.32% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
137,579 |
568,000 |
0.32% |
|
|
| 33 |
Weiss Multi-Strategy Advisers LLC |
130,000 |
537,000 |
0.30% |
|
|
| 34 |
TANAKA CAPITAL MANAGEMENT INC |
111,693 |
462,000 |
0.26% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
110,543 |
457,000 |
0.25% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
107,345 |
444,000 |
0.25% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
95,823 |
396,000 |
0.22% |
|
|
| 38 |
March Altus Capital Management LP |
80,890 |
334,000 |
0.19% |
|
|
| 39 |
CITADEL ADVISORS LLC |
79,761 |
329,000 |
0.18% |
|
|
| 40 |
CORRADO ADVISORS, LLC |
79,450 |
328,000 |
0.18% |
|
|
| 41 |
PANAGORA ASSET MANAGEMENT INC |
74,011 |
306,000 |
0.17% |
|
|
| 42 |
RHUMBLINE ADVISERS |
64,765 |
267,000 |
0.15% |
|
|
| 43 |
METROPOLITAN LIFE INSURANCE CO/NY |
56,871 |
235,000 |
0.13% |
|
|
| 44 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
52,500 |
217,000 |
0.12% |
Call |
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
49,577 |
205,000 |
0.11% |
|
|
| 46 |
Nationwide Fund Advisors |
48,423 |
200,000 |
0.11% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
44,144 |
182,315 |
0.10% |
|
|
| 48 |
NEW YORK STATE COMMON RETIREMENT FUND |
43,293 |
179,000 |
0.10% |
|
|
| 49 |
VOYA INVESTMENT MANAGEMENT LLC |
42,497 |
176,000 |
0.10% |
|
|
| 50 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,332 |
171,000 |
0.09% |
|
|
