| 1 |
BAKER BROS. ADVISORS LP |
8,275,630 |
20,275,000 |
19.57% |
|
|
| 2 |
FEDERATED HERMES, INC. |
4,582,320 |
11,227,000 |
10.83% |
|
|
| 3 |
Broadfin Capital, LLC |
4,183,177 |
10,249,000 |
9.89% |
|
|
| 4 |
Consonance Capital Management LP |
2,888,942 |
7,078,000 |
6.83% |
|
|
| 5 |
VANGUARD GROUP INC |
2,596,829 |
6,362,000 |
6.14% |
|
|
| 6 |
Point72 Asset Management, L.P. |
2,276,923 |
5,578,000 |
5.38% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
2,127,100 |
5,211,000 |
5.03% |
|
|
| 8 |
BlackRock Fund Advisors |
2,042,501 |
5,004,000 |
4.83% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
1,455,000 |
3,565,000 |
3.44% |
|
|
| 10 |
STATE STREET CORP |
1,132,629 |
2,777,000 |
2.68% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
1,111,750 |
2,724,000 |
2.63% |
|
|
| 12 |
PERCEPTIVE ADVISORS LLC |
851,200 |
2,085,000 |
2.01% |
|
|
| 13 |
Allianz Asset Management GmbH |
820,853 |
2,011,000 |
1.94% |
|
|
| 14 |
NORTHERN TRUST CORP |
764,108 |
1,873,000 |
1.81% |
|
|
| 15 |
JPMORGAN CHASE & CO |
602,300 |
1,476,000 |
1.42% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
475,673 |
1,165,000 |
1.12% |
|
|
| 17 |
COLUMBUS CIRCLE INVESTORS |
418,384 |
1,025,000 |
0.99% |
|
|
| 18 |
Invesco Ltd. |
413,770 |
1,014,000 |
0.98% |
|
|
| 19 |
Ghost Tree Capital, LLC |
376,000 |
921,000 |
0.89% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
356,430 |
872,000 |
0.84% |
|
|
| 21 |
BLACKROCK ADVISORS LLC |
330,820 |
811,000 |
0.78% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
316,465 |
775,000 |
0.75% |
|
|
| 23 |
Catalyst Capital Advisors LLC |
305,000 |
748,000 |
0.72% |
|
|
| 24 |
BlackRock Investment Management, LLC |
270,444 |
663,000 |
0.64% |
|
|
| 25 |
Bank of New York Mellon Corp |
266,820 |
654,000 |
0.63% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
256,861 |
629,000 |
0.61% |
|
|
| 27 |
KENNEDY CAPITAL MANAGEMENT LLC |
248,217 |
608,000 |
0.59% |
|
|
| 28 |
MILLENNIUM MANAGEMENT LLC |
247,829 |
607,000 |
0.59% |
|
|
| 29 |
CITADEL ADVISORS LLC |
178,634 |
437,000 |
0.42% |
|
|
| 30 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
145,877 |
358,000 |
0.35% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
139,573 |
342,000 |
0.33% |
|
|
| 32 |
Employees Retirement System of Texas |
138,000 |
338,000 |
0.33% |
|
|
| 33 |
Weiss Multi-Strategy Advisers LLC |
122,000 |
299,000 |
0.29% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
110,543 |
271,000 |
0.26% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
107,345 |
263,000 |
0.25% |
|
|
| 36 |
TANAKA CAPITAL MANAGEMENT INC |
111,693 |
237,000 |
0.23% |
|
|
| 37 |
RHUMBLINE ADVISERS |
75,216 |
184,000 |
0.18% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
68,800 |
169,000 |
0.16% |
|
|
| 39 |
AQR CAPITAL MANAGEMENT LLC |
63,742 |
156,000 |
0.15% |
|
|
| 40 |
CREDIT SUISSE AG/ |
56,428 |
137,000 |
0.13% |
|
|
| 41 |
METROPOLITAN LIFE INSURANCE CO/NY |
55,663 |
136,000 |
0.13% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
49,577 |
121,000 |
0.12% |
|
|
| 43 |
Nationwide Fund Advisors |
48,423 |
119,000 |
0.11% |
|
|
| 44 |
AMERICAN INTERNATIONAL GROUP, INC. |
44,119 |
108,000 |
0.10% |
|
|
| 45 |
Quantitative Systematic Strategies LLC |
41,502 |
105,000 |
0.10% |
|
|
| 46 |
VOYA INVESTMENT MANAGEMENT LLC |
42,497 |
104,000 |
0.10% |
|
|
| 47 |
Independence Trust CO |
42,000 |
103,000 |
0.10% |
|
|
| 48 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,332 |
101,000 |
0.10% |
|
|
| 49 |
BOOTHBAY FUND MANAGEMENT, LLC |
39,695 |
97,000 |
0.09% |
|
|
| 50 |
AGRAN LIBBIE |
34,200 |
87,000 |
0.08% |
|
|
