| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 6,715,462 | 22,295,000 | 27.08% | ||
| 2 | FEDERATED HERMES, INC. | 3,048,500 | 10,121,000 | 12.29% | ||
| 3 | FRANKLIN RESOURCES INC | 2,511,600 | 8,339,000 | 10.13% | ||
| 4 | VANGUARD GROUP INC | 1,875,449 | 6,227,000 | 7.56% | ||
| 5 | Visium Asset Management, LP | 1,500,000 | 4,980,000 | 6.05% | ||
| 6 | Broadfin Capital, LLC | 1,400,000 | 4,648,000 | 5.64% | ||
| 7 | MORGAN STANLEY | 1,236,179 | 4,104,000 | 4.98% | ||
| 8 | Opaleye Management Inc. | 975,000 | 3,237,000 | 3.93% | ||
| 9 | Catalyst Capital Advisors LLC | 955,000 | 3,171,000 | 3.85% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 750,000 | 2,490,000 | 3.02% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 685,500 | 2,276,000 | 2.76% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 315,100 | 1,046,000 | 1.27% | Call | |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 282,334 | 937,000 | 1.14% | ||
| 14 | AQR CAPITAL MANAGEMENT LLC | 240,282 | 798,000 | 0.97% | ||
| 15 | DEUTSCHE BANK AG\ | 237,800 | 789,000 | 0.96% | ||
| 16 | TFS CAPITAL LLC | 229,040 | 760,000 | 0.92% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 196,500 | 652,000 | 0.79% | ||
| 18 | BlackRock Fund Advisors | 175,660 | 583,000 | 0.71% | ||
| 19 | Weiss Multi-Strategy Advisers LLC | 150,000 | 498,000 | 0.60% | ||
| 20 | TANAKA CAPITAL MANAGEMENT INC | 147,993 | 414,000 | 0.50% | ||
| 21 | NORTHERN TRUST CORP | 89,414 | 297,000 | 0.36% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 82,770 | 275,000 | 0.33% | ||
| 23 | CITADEL ADVISORS LLC | 82,919 | 275,000 | 0.33% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 78,359 | 260,000 | 0.32% | ||
| 25 | COWEN INC. | 106,250 | 255,000 | 0.31% | ||
| 26 | Paloma Partners Management Co | 71,994 | 239,000 | 0.29% | ||
| 27 | Bank of New York Mellon Corp | 66,956 | 222,000 | 0.27% | ||
| 28 | A.R.T. Advisors, LLC | 62,081 | 206,000 | 0.25% | ||
| 29 | NOMURA HOLDINGS INC | 54,640 | 181,000 | 0.22% | ||
| 30 | STATE STREET CORP | 49,400 | 164,000 | 0.20% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 46,438 | 154,000 | 0.19% | ||
| 32 | JANE STREET GROUP, LLC | 46,039 | 153,000 | 0.19% | ||
| 33 | CREDIT SUISSE AG/ | 45,384 | 151,000 | 0.18% | ||
| 34 | Cowen Prime Services LLC | 43,025 | 143,000 | 0.17% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,332 | 137,000 | 0.17% | ||
| 36 | Financial Architects, Inc | 30,000 | 100,000 | 0.12% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,300 | 91,000 | 0.11% | Put | |
| 38 | Rotella Capital Management, Inc. | 22,852 | 76,000 | 0.09% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,900 | 76,000 | 0.09% | Call | |
| 40 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20,998 | 70,000 | 0.09% | ||
| 41 | AGRAN LIBBIE | 20,000 | 66,000 | 0.08% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,295 | 51,000 | 0.06% | ||
| 43 | GOLDMAN SACHS GROUP INC | 12,220 | 41,000 | 0.05% | ||
| 44 | Nine Chapters Capital Management LLC | 10,900 | 36,000 | 0.04% | ||
| 45 | CITIGROUP INC | 10,096 | 34,000 | 0.04% | ||
| 46 | BlackRock Investment Management, LLC | 10,313 | 34,000 | 0.04% | ||
| 47 | Janney Montgomery Scott LLC | 10,000 | 33,200 | 0.04% | ||
| 48 | Creative Planning | 8,231 | 27,000 | 0.03% | ||
| 49 | Spot Trading L.L.C | 7,785 | 26,000 | 0.03% | ||
| 50 | FIRST NEW YORK SECURITIES LLC /NY | 7,500 | 24,900 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
