| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,565,462 | 32,758,000 | 19.49% | ||
| 2 | Point72 Asset Management, L.P. | 6,568,000 | 28,439,000 | 16.92% | ||
| 3 | Consonance Capital Management LP | 4,849,870 | 21,000,000 | 12.49% | ||
| 4 | Broadfin Capital, LLC | 4,083,177 | 17,680,000 | 10.52% | ||
| 5 | FRANKLIN RESOURCES INC | 2,511,600 | 10,875,000 | 6.47% | ||
| 6 | VANGUARD GROUP INC | 2,228,589 | 9,650,000 | 5.74% | ||
| 7 | FEDERATED HERMES, INC. | 1,985,000 | 8,595,000 | 5.11% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 1,200,000 | 5,196,000 | 3.09% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 1,100,000 | 4,763,000 | 2.83% | ||
| 10 | Catalyst Capital Advisors LLC | 1,075,000 | 4,655,000 | 2.77% | ||
| 11 | MORGAN STANLEY | 770,731 | 3,338,000 | 1.99% | ||
| 12 | PURA VIDA INVESTMENTS, LLC | 365,000 | 1,580,000 | 0.94% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 352,848 | 1,527,000 | 0.91% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 344,754 | 1,493,000 | 0.89% | ||
| 15 | Allianz Asset Management GmbH | 313,523 | 1,358,000 | 0.81% | ||
| 16 | DEUTSCHE BANK AG\ | 242,493 | 1,049,000 | 0.62% | ||
| 17 | Informed Momentum Co LLC | 232,176 | 1,005,000 | 0.60% | ||
| 18 | RUSSELL FRANK CO/ | 201,802 | 874,000 | 0.52% | ||
| 19 | AQR CAPITAL MANAGEMENT LLC | 184,782 | 800,000 | 0.48% | ||
| 20 | BlackRock Fund Advisors | 184,773 | 800,000 | 0.48% | ||
| 21 | CREDIT SUISSE AG/ | 160,169 | 693,000 | 0.41% | ||
| 22 | TFS CAPITAL LLC | 157,195 | 681,000 | 0.41% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 151,110 | 654,000 | 0.39% | ||
| 24 | Weiss Multi-Strategy Advisers LLC | 148,000 | 641,000 | 0.38% | ||
| 25 | Employees Retirement System of Texas | 138,000 | 598,000 | 0.36% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 124,399 | 539,000 | 0.32% | ||
| 27 | EMERALD MUTUAL FUND ADVISERS TRUST | 150,000 | 533,000 | 0.32% | ||
| 28 | BlueCrest Capital Management Ltd | 119,054 | 516,000 | 0.31% | ||
| 29 | CORRADO ADVISORS, LLC | 105,700 | 458,000 | 0.27% | ||
| 30 | GOLDMAN SACHS GROUP INC | 102,924 | 446,000 | 0.27% | ||
| 31 | TANAKA CAPITAL MANAGEMENT INC | 111,693 | 438,000 | 0.26% | ||
| 32 | NORTHERN TRUST CORP | 96,429 | 418,000 | 0.25% | ||
| 33 | Bank of New York Mellon Corp | 92,201 | 399,000 | 0.24% | ||
| 34 | A.R.T. Advisors, LLC | 92,100 | 398,000 | 0.24% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 82,372 | 357,000 | 0.21% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 64,259 | 278,000 | 0.17% | ||
| 37 | PIPER SANDLER & CO. | 50,000 | 217,000 | 0.13% | ||
| 38 | DIMENSIONAL FUND ADVISORS LP | 46,438 | 201,000 | 0.12% | ||
| 39 | STATE STREET CORP | 44,400 | 193,000 | 0.11% | ||
| 40 | Cowen Prime Services LLC | 43,025 | 186,000 | 0.11% | ||
| 41 | WELLS FARGO & COMPANY/MN | 37,875 | 164,000 | 0.10% | ||
| 42 | CITADEL ADVISORS LLC | 35,298 | 153,000 | 0.09% | ||
| 43 | STIFEL FINANCIAL CORP | 35,000 | 152,000 | 0.09% | ||
| 44 | AGRAN LIBBIE | 34,000 | 147,000 | 0.09% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 41,332 | 138,000 | 0.08% | ||
| 46 | Financial Architects, Inc | 30,000 | 130,000 | 0.08% | ||
| 47 | Verition Fund Management LLC | 23,050 | 100,000 | 0.06% | ||
| 48 | RENAISSANCE TECHNOLOGIES LLC | 21,227 | 92,000 | 0.05% | ||
| 49 | CTC Alternative Strategies, Ltd. | 18,000 | 77,940 | 0.05% | ||
| 50 | TRADELINK CAPITAL LLC | 17,220 | 75,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
