| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,335,692 | 22,007,000 | 16.40% | ||
| 2 | Consonance Capital Management LP | 5,802,885 | 17,409,000 | 12.97% | ||
| 3 | FEDERATED HERMES, INC. | 4,582,320 | 13,747,000 | 10.24% | ||
| 4 | Broadfin Capital, LLC | 4,183,177 | 12,550,000 | 9.35% | ||
| 5 | VANGUARD GROUP INC | 2,530,878 | 7,593,000 | 5.66% | ||
| 6 | Point72 Asset Management, L.P. | 2,206,264 | 6,619,000 | 4.93% | ||
| 7 | FRANKLIN RESOURCES INC | 2,127,100 | 6,381,000 | 4.76% | ||
| 8 | BlackRock Fund Advisors | 1,958,285 | 5,875,000 | 4.38% | ||
| 9 | SPHERA FUNDS MANAGEMENT LTD. | 1,100,000 | 3,300,000 | 2.46% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,080,832 | 3,242,000 | 2.42% | ||
| 11 | STATE STREET CORP | 1,030,431 | 3,095,000 | 2.31% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 851,200 | 2,554,000 | 1.90% | ||
| 13 | Allianz Asset Management GmbH | 813,346 | 2,440,000 | 1.82% | ||
| 14 | NORTHERN TRUST CORP | 763,513 | 2,291,000 | 1.71% | ||
| 15 | DEUTSCHE BANK AG\ | 739,904 | 2,218,000 | 1.65% | ||
| 16 | JPMORGAN CHASE & CO | 699,500 | 2,098,000 | 1.56% | ||
| 17 | COLUMBUS CIRCLE INVESTORS | 564,659 | 1,694,000 | 1.26% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 470,072 | 1,410,000 | 1.05% | ||
| 19 | Invesco Ltd. | 412,753 | 1,238,000 | 0.92% | ||
| 20 | HealthCor Management, L.P. | 385,500 | 1,157,000 | 0.86% | ||
| 21 | TURNER INVESTMENTS LLC | 366,490 | 1,099,000 | 0.82% | ||
| 22 | Ghost Tree Capital, LLC | 350,000 | 1,050,000 | 0.78% | ||
| 23 | BLACKROCK ADVISORS LLC | 347,811 | 1,043,000 | 0.78% | ||
| 24 | Catalyst Capital Advisors LLC | 305,000 | 915,000 | 0.68% | ||
| 25 | BlackRock Investment Management, LLC | 269,027 | 807,000 | 0.60% | ||
| 26 | Bank of New York Mellon Corp | 267,475 | 803,000 | 0.60% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 256,861 | 771,000 | 0.57% | ||
| 28 | KENNEDY CAPITAL MANAGEMENT LLC | 249,071 | 747,000 | 0.56% | ||
| 29 | CITADEL ADVISORS LLC | 142,223 | 426,000 | 0.32% | ||
| 30 | AQR CAPITAL MANAGEMENT LLC | 139,562 | 419,000 | 0.31% | ||
| 31 | D. E. Shaw & Co., Inc. | 138,845 | 417,000 | 0.31% | ||
| 32 | Employees Retirement System of Texas | 138,000 | 414,000 | 0.31% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 137,079 | 411,000 | 0.31% | ||
| 34 | RUSSELL FRANK CO/ | 135,329 | 406,000 | 0.30% | ||
| 35 | Weiss Multi-Strategy Advisers LLC | 122,000 | 366,000 | 0.27% | ||
| 36 | TANAKA CAPITAL MANAGEMENT INC | 111,693 | 335,000 | 0.25% | ||
| 37 | TEACHERS ADVISORS, LLC | 110,543 | 332,000 | 0.25% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,345 | 323,000 | 0.24% | ||
| 39 | PURA VIDA INVESTMENTS, LLC | 100,129 | 300,000 | 0.22% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 68,800 | 206,000 | 0.15% | ||
| 41 | RHUMBLINE ADVISERS | 68,506 | 206,000 | 0.15% | ||
| 42 | BOOTHBAY FUND MANAGEMENT, LLC | 63,667 | 191,000 | 0.14% | ||
| 43 | Informed Momentum Co LLC | 60,858 | 183,000 | 0.14% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 59,489 | 178,000 | 0.13% | ||
| 45 | SYMPHONY ASSET MANAGEMENT LLC | 55,126 | 165,000 | 0.12% | ||
| 46 | Virtu KCG Holdings LLC | 50,800 | 152,000 | 0.11% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,577 | 148,000 | 0.11% | ||
| 48 | Nationwide Fund Advisors | 48,423 | 145,000 | 0.11% | ||
| 49 | MORGAN STANLEY | 47,308 | 142,000 | 0.11% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 47,445 | 142,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
