| 1 |
BAKER BROS. ADVISORS LP |
3,537,137 |
40,889,000 |
16.25% |
|
|
| 2 |
FMR LLC |
1,988,900 |
22,992,000 |
9.14% |
|
|
| 3 |
Broadfin Capital, LLC |
1,824,377 |
21,090,000 |
8.38% |
|
|
| 4 |
Consonance Capital Management LP |
1,451,692 |
16,782,000 |
6.67% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
1,148,292 |
13,275,000 |
5.28% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
1,147,940 |
13,270,000 |
5.27% |
|
|
| 7 |
JPMORGAN CHASE & CO |
1,045,587 |
12,087,000 |
4.80% |
|
|
| 8 |
HealthCor Management, L.P. |
920,000 |
10,635,000 |
4.23% |
|
|
| 9 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
652,430 |
7,542,000 |
3.00% |
|
|
| 10 |
THB ASSET MANAGEMENT |
619,110 |
7,156,000 |
2.84% |
|
|
| 11 |
Redmile Group, LLC |
600,677 |
6,944,000 |
2.76% |
|
|
| 12 |
Senvest Management, LLC |
593,665 |
6,863,000 |
2.73% |
|
|
| 13 |
BlackRock Fund Advisors |
563,597 |
6,515,000 |
2.59% |
|
|
| 14 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
517,900 |
5,987,000 |
2.38% |
|
|
| 15 |
VANGUARD GROUP INC |
499,861 |
5,778,000 |
2.30% |
|
|
| 16 |
ORACLE INVESTMENT MANAGEMENT INC |
492,796 |
5,696,722 |
2.26% |
|
|
| 17 |
PERCEPTIVE ADVISORS LLC |
406,437 |
4,698,000 |
1.87% |
|
|
| 18 |
DAFNA Capital Management LLC |
384,794 |
4,448,000 |
1.77% |
|
|
| 19 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
374,162 |
4,325,000 |
1.72% |
|
|
| 20 |
Granahan Investment Management, LLC |
361,072 |
4,174,000 |
1.66% |
|
|
| 21 |
ORBIMED ADVISORS LLC |
300,000 |
3,468,000 |
1.38% |
|
|
| 22 |
NORTHERN TRUST CORP |
250,312 |
2,894,000 |
1.15% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
244,818 |
2,830,000 |
1.12% |
|
|
| 24 |
STATE STREET CORP |
237,213 |
2,742,000 |
1.09% |
|
|
| 25 |
Bank of New York Mellon Corp |
167,295 |
1,934,000 |
0.77% |
|
|
| 26 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
150,000 |
1,734,000 |
0.69% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
124,142 |
1,435,000 |
0.57% |
|
|
| 28 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
112,117 |
1,296,000 |
0.51% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
100,966 |
1,167,000 |
0.46% |
|
|
| 30 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
93,058 |
1,076,000 |
0.43% |
|
|
| 31 |
BlackRock Investment Management, LLC |
73,523 |
850,000 |
0.34% |
|
|
| 32 |
FIL Ltd |
69,412 |
802,000 |
0.32% |
|
|
| 33 |
COMMERCE BANK |
65,958 |
762,000 |
0.30% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
653,000 |
0.26% |
|
|
| 35 |
ROYCE & ASSOCIATES LP |
55,000 |
636,000 |
0.25% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
45,283 |
523,000 |
0.21% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,385 |
478,000 |
0.19% |
|
|
| 38 |
SYMPHONY ASSET MANAGEMENT LLC |
35,983 |
416,000 |
0.17% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
30,694 |
355,000 |
0.14% |
|
|
| 40 |
PEAK6 Group LLC |
29,600 |
342,000 |
0.14% |
Call |
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,500 |
330,000 |
0.13% |
|
|
| 42 |
RHUMBLINE ADVISERS |
25,074 |
290,000 |
0.12% |
|
|
| 43 |
Allianz Asset Management GmbH |
20,485 |
237,000 |
0.09% |
|
|
| 44 |
ARDSLEY ADVISORY PARTNERS LP |
20,000 |
231,000 |
0.09% |
|
|
| 45 |
UBS AG |
18,359 |
213,000 |
0.08% |
|
|
| 46 |
Nationwide Fund Advisors |
17,184 |
199,000 |
0.08% |
|
|
| 47 |
METROPOLITAN LIFE INSURANCE CO/NY |
17,034 |
197,000 |
0.08% |
|
|
| 48 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
16,519 |
191,000 |
0.08% |
|
|
| 49 |
ANDERSON HOAGLAND & CO |
15,000 |
173,000 |
0.07% |
|
|
| 50 |
AMERICAN INTERNATIONAL GROUP, INC. |
14,812 |
171,227 |
0.07% |
|
|
