| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 348,784 | 24,997,000 | 14.34% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,457,841 | 24,758,000 | 14.20% | ||
| 3 | FMR LLC | 2,487,505 | 17,811,000 | 10.22% | ||
| 4 | Broadfin Capital, LLC | 2,317,489 | 16,593,000 | 9.52% | ||
| 5 | Consonance Capital Management LP | 1,760,649 | 12,606,000 | 7.23% | ||
| 6 | Senvest Management, LLC | 1,152,626 | 8,253,000 | 4.73% | ||
| 7 | JENNISON ASSOCIATES LLC | 1,140,446 | 8,166,000 | 4.68% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 968,881 | 6,937,000 | 3.98% | ||
| 9 | J. Goldman & Co LP | 622,500 | 4,457,000 | 2.56% | ||
| 10 | VANGUARD GROUP INC | 562,397 | 4,027,000 | 2.31% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 535,428 | 3,834,000 | 2.20% | ||
| 12 | Granahan Investment Management, LLC | 534,450 | 3,827,000 | 2.20% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 2,864,000 | 1.64% | ||
| 14 | ROYCE & ASSOCIATES LP | 392,500 | 2,810,000 | 1.61% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 381,907 | 2,734,000 | 1.57% | ||
| 16 | DAFNA Capital Management LLC | 373,918 | 2,677,000 | 1.54% | SH | |
| 17 | FIL Ltd | 310,987 | 2,227,000 | 1.28% | ||
| 18 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 300,000 | 2,148,000 | 1.23% | ||
| 19 | GREAT POINT PARTNERS LLC | 280,000 | 2,005,000 | 1.15% | ||
| 20 | ROANOKE ASSET MANAGEMENT CORP/ NY | 273,926 | 1,961,000 | 1.12% | ||
| 21 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 270,932 | 1,939,000 | 1.11% | ||
| 22 | GOLDMAN SACHS GROUP INC | 212,947 | 1,525,000 | 0.87% | ||
| 23 | NORTHERN TRUST CORP | 206,987 | 1,482,000 | 0.85% | ||
| 24 | DEUTSCHE BANK AG\ | 196,476 | 1,406,000 | 0.81% | ||
| 25 | PUTNAM INVESTMENTS LLC | 179,880 | 1,288,000 | 0.74% | ||
| 26 | Bank of New York Mellon Corp | 164,933 | 1,182,000 | 0.68% | ||
| 27 | D. E. Shaw & Co., Inc. | 153,172 | 1,097,000 | 0.63% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 130,827 | 936,000 | 0.54% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,802 | 872,000 | 0.50% | ||
| 30 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 104,258 | 746,000 | 0.43% | ||
| 31 | CREDIT SUISSE AG/ | 87,003 | 623,000 | 0.36% | ||
| 32 | BlackRock Institutional Trust Company, N.A. | 72,045 | 516,000 | 0.30% | ||
| 33 | COMMERCE BANK | 65,958 | 472,000 | 0.27% | ||
| 34 | BlackRock Fund Advisors | 57,868 | 414,000 | 0.24% | ||
| 35 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,500 | 405,000 | 0.23% | ||
| 36 | Granite Point Capital Management, L.P. | 55,080 | 394,000 | 0.23% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 48,909 | 350,000 | 0.20% | ||
| 38 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 38,471 | 275,000 | 0.16% | ||
| 39 | PEAK6 Group LLC | 37,871 | 271,000 | 0.16% | ||
| 40 | Paloma Partners Management Co | 34,900 | 250,000 | 0.14% | ||
| 41 | JANE STREET GROUP, LLC | 29,887 | 214,000 | 0.12% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 29,206 | 209,000 | 0.12% | ||
| 43 | IRIDIAN ASSET MANAGEMENT LLC/CT | 27,020 | 193,000 | 0.11% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 24,885 | 178,000 | 0.10% | ||
| 45 | UBS Group AG | 24,288 | 173,000 | 0.10% | ||
| 46 | MORGAN STANLEY | 22,490 | 161,000 | 0.09% | ||
| 47 | LMR Partners LLP | 22,110 | 158,000 | 0.09% | ||
| 48 | BlackRock Group LTD | 17,274 | 124,000 | 0.07% | ||
| 49 | Alpine Global Management, LLC | 16,726 | 120,000 | 0.07% | ||
| 50 | STATE STREET CORP | 15,658 | 112,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
