| 1 |
BAKER BROS. ADVISORS LP |
3,752,390 |
17,148,000 |
17.96% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,619,308 |
11,970,000 |
12.54% |
|
|
| 3 |
Broadfin Capital, LLC |
2,562,104 |
11,709,000 |
12.26% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
1,407,506 |
6,432,000 |
6.74% |
|
|
| 5 |
Senvest Management, LLC |
1,094,037 |
5,000,000 |
5.24% |
|
|
| 6 |
Granahan Investment Management, LLC |
978,318 |
4,471,000 |
4.68% |
|
|
| 7 |
Consonance Capital Management LP |
937,516 |
4,284,000 |
4.49% |
|
|
| 8 |
Krensavage Asset Management, LLC |
901,834 |
4,121,000 |
4.32% |
|
|
| 9 |
VANGUARD GROUP INC |
680,755 |
3,111,000 |
3.26% |
|
|
| 10 |
RA CAPITAL MANAGEMENT, L.P. |
641,236 |
2,930,000 |
3.07% |
|
|
| 11 |
STONEPINE CAPITAL MANAGEMENT, LLC |
507,799 |
2,321,000 |
2.43% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
439,300 |
2,008,000 |
2.10% |
|
|
| 13 |
PERCEPTIVE ADVISORS LLC |
402,884 |
1,841,000 |
1.93% |
|
|
| 14 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
400,000 |
1,828,000 |
1.91% |
|
|
| 15 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
384,045 |
1,755,000 |
1.84% |
|
|
| 16 |
DAFNA Capital Management LLC |
353,718 |
1,616,000 |
1.69% |
|
SH |
| 17 |
FIL Ltd |
310,987 |
1,421,000 |
1.49% |
|
|
| 18 |
D. E. Shaw & Co., Inc. |
301,122 |
1,376,000 |
1.44% |
|
|
| 19 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
245,059 |
1,120,000 |
1.17% |
|
|
| 20 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
240,896 |
1,101,000 |
1.15% |
|
|
| 21 |
ROYCE & ASSOCIATES LP |
237,507 |
1,085,000 |
1.14% |
|
|
| 22 |
AWM Investment Company, Inc. |
188,995 |
864,000 |
0.90% |
|
|
| 23 |
OXFORD ASSET MANAGEMENT LLP |
172,795 |
783,000 |
0.82% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
150,544 |
687,000 |
0.72% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
149,439 |
683,000 |
0.72% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
69,913 |
320,000 |
0.34% |
|
|
| 27 |
BlackRock Fund Advisors |
59,387 |
271,000 |
0.28% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
258,000 |
0.27% |
|
|
| 29 |
NORTHERN TRUST CORP |
52,629 |
240,000 |
0.25% |
|
|
| 30 |
FT OPTIONS LLC |
50,817 |
232,000 |
0.24% |
|
|
| 31 |
COMMERCE BANK |
48,958 |
224,000 |
0.23% |
|
|
| 32 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
43,360 |
198,000 |
0.21% |
|
|
| 33 |
DIMENSIONAL FUND ADVISORS LP |
42,649 |
195,000 |
0.20% |
|
|
| 34 |
Bank of New York Mellon Corp |
37,390 |
170,000 |
0.18% |
|
|
| 35 |
A.R.T. Advisors, LLC |
34,887 |
159,000 |
0.17% |
|
|
| 36 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
28,600 |
131,000 |
0.14% |
|
|
| 37 |
CREDIT SUISSE AG/ |
24,507 |
112,000 |
0.12% |
|
|
| 38 |
BALYASNY ASSET MANAGEMENT L.P. |
23,880 |
109,000 |
0.11% |
|
|
| 39 |
Nationwide Fund Advisors |
22,139 |
101,000 |
0.11% |
|
|
| 40 |
Connor, Clark & Lunn Investment Management Ltd. |
20,100 |
92,000 |
0.10% |
|
|
| 41 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
17,776 |
81,000 |
0.08% |
|
|
| 42 |
DEUTSCHE BANK AG\ |
17,895 |
81,000 |
0.08% |
|
|
| 43 |
BlackRock Group LTD |
17,274 |
79,000 |
0.08% |
|
|
| 44 |
Squarepoint Ops LLC |
17,000 |
78,000 |
0.08% |
|
|
| 45 |
STATE STREET CORP |
15,658 |
71,000 |
0.07% |
|
|
| 46 |
GOLDMAN SACHS GROUP INC |
15,347 |
70,000 |
0.07% |
|
|
| 47 |
Commonwealth Equity Services, Inc |
14,850 |
68,000 |
0.07% |
|
|
| 48 |
Spark Investment Management LLC |
14,400 |
65,000 |
0.07% |
|
|
| 49 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13,800 |
63,000 |
0.07% |
Put |
|
| 50 |
PEAK6 Group LLC |
13,600 |
62,000 |
0.06% |
Call |
|
