| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 3,457,841 | 16,286,000 | 17.19% | ||
| 2 | FMR LLC | 2,487,505 | 11,716,000 | 12.37% | ||
| 3 | Broadfin Capital, LLC | 2,362,104 | 11,126,000 | 11.74% | ||
| 4 | Consonance Capital Management LP | 1,893,467 | 8,918,000 | 9.41% | ||
| 5 | Senvest Management, LLC | 1,152,626 | 5,429,000 | 5.73% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,145,688 | 5,396,000 | 5.70% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,002,201 | 4,720,000 | 4.98% | ||
| 8 | VANGUARD GROUP INC | 590,430 | 2,781,000 | 2.94% | ||
| 9 | Granahan Investment Management, LLC | 505,150 | 2,379,000 | 2.51% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 469,320 | 2,210,000 | 2.33% | ||
| 11 | J. Goldman & Co LP | 445,300 | 2,097,000 | 2.21% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 1,884,000 | 1.99% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 360,584 | 1,698,000 | 1.79% | ||
| 14 | DAFNA Capital Management LLC | 356,918 | 1,681,000 | 1.77% | SH | |
| 15 | FIL Ltd | 310,987 | 1,465,000 | 1.55% | ||
| 16 | Ghost Tree Capital, LLC | 300,000 | 1,413,000 | 1.49% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 281,000 | 1,324,000 | 1.40% | ||
| 18 | ROANOKE ASSET MANAGEMENT CORP/ NY | 273,926 | 1,290,000 | 1.36% | ||
| 19 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 233,389 | 1,099,000 | 1.16% | ||
| 20 | ROYCE & ASSOCIATES LP | 221,507 | 1,043,000 | 1.10% | ||
| 21 | D. E. Shaw & Co., Inc. | 200,260 | 943,000 | 1.00% | ||
| 22 | PUTNAM INVESTMENTS LLC | 179,110 | 844,000 | 0.89% | ||
| 23 | GOLDMAN SACHS GROUP INC | 172,519 | 813,000 | 0.86% | ||
| 24 | Bank of New York Mellon Corp | 170,848 | 805,000 | 0.85% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 127,471 | 600,000 | 0.63% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 105,480 | 497,000 | 0.52% | ||
| 27 | GREAT POINT PARTNERS LLC | 101,235 | 477,000 | 0.50% | ||
| 28 | DEUTSCHE BANK AG\ | 97,189 | 457,000 | 0.48% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 88,317 | 416,000 | 0.44% | ||
| 30 | CITADEL ADVISORS LLC | 71,672 | 338,000 | 0.36% | ||
| 31 | COMMERCE BANK | 65,958 | 311,000 | 0.33% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 64,974 | 306,000 | 0.32% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,500 | 266,000 | 0.28% | ||
| 34 | BlackRock Fund Advisors | 56,380 | 266,000 | 0.28% | ||
| 35 | NORTHERN TRUST CORP | 48,229 | 228,000 | 0.24% | ||
| 36 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 46,159 | 217,000 | 0.23% | ||
| 37 | DIMENSIONAL FUND ADVISORS LP | 34,006 | 160,000 | 0.17% | ||
| 38 | IRIDIAN ASSET MANAGEMENT LLC/CT | 30,595 | 144,000 | 0.15% | ||
| 39 | UBS Group AG | 28,400 | 134,000 | 0.14% | ||
| 40 | MORGAN STANLEY | 17,649 | 83,000 | 0.09% | ||
| 41 | BlackRock Group LTD | 17,274 | 81,000 | 0.09% | ||
| 42 | STATE STREET CORP | 15,658 | 74,000 | 0.08% | ||
| 43 | JACOBS LEVY EQUITY MANAGEMENT, INC | 15,200 | 72,000 | 0.08% | ||
| 44 | Commonwealth Equity Services, Inc | 14,350 | 68,000 | 0.07% | ||
| 45 | PEAK6 Group LLC | 7,400 | 35,000 | 0.04% | Put | |
| 46 | CITIGROUP INC | 5,810 | 27,000 | 0.03% | ||
| 47 | VALLEY NATIONAL ADVISERS INC | 5,000 | 24,000 | 0.03% | ||
| 48 | Tower Research Capital LLC (TRC) | 4,931 | 23,000 | 0.02% | ||
| 49 | WELLS FARGO & COMPANY/MN | 4,427 | 21,000 | 0.02% | ||
| 50 | BlackRock Investment Management, LLC | 3,882 | 18,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
