| 1 |
BAKER BROS. ADVISORS LP |
3,537,137 |
29,464,000 |
16.70% |
|
|
| 2 |
FMR LLC |
1,977,200 |
16,470,000 |
9.33% |
|
|
| 3 |
Broadfin Capital, LLC |
1,824,377 |
15,197,000 |
8.61% |
|
|
| 4 |
Consonance Capital Management LP |
1,520,404 |
12,665,000 |
7.18% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
1,161,604 |
9,676,000 |
5.48% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
1,149,314 |
9,574,000 |
5.43% |
|
|
| 7 |
JPMORGAN CHASE & CO |
1,045,587 |
8,710,000 |
4.94% |
|
|
| 8 |
HealthCor Management, L.P. |
920,000 |
7,664,000 |
4.34% |
|
|
| 9 |
Senvest Management, LLC |
801,445 |
6,676,000 |
3.78% |
|
|
| 10 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
665,437 |
5,543,000 |
3.14% |
|
|
| 11 |
THB ASSET MANAGEMENT |
635,450 |
5,293,000 |
3.00% |
|
|
| 12 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
554,057 |
4,615,000 |
2.62% |
|
|
| 13 |
BlackRock Fund Advisors |
533,251 |
4,442,000 |
2.52% |
|
|
| 14 |
VANGUARD GROUP INC |
528,997 |
4,406,000 |
2.50% |
|
|
| 15 |
DAFNA Capital Management LLC |
384,794 |
3,205,000 |
1.82% |
|
SH |
| 16 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
368,350 |
3,068,000 |
1.74% |
|
|
| 17 |
Granahan Investment Management, LLC |
358,579 |
2,987,000 |
1.69% |
|
|
| 18 |
ORACLE INVESTMENT MANAGEMENT INC |
326,844 |
2,723,000 |
1.54% |
|
|
| 19 |
ORBIMED ADVISORS LLC |
300,000 |
2,499,000 |
1.42% |
|
|
| 20 |
NORTHERN TRUST CORP |
253,753 |
2,114,000 |
1.20% |
|
|
| 21 |
STATE STREET CORP |
244,526 |
2,035,000 |
1.15% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
231,304 |
1,927,000 |
1.09% |
|
|
| 23 |
PERCEPTIVE ADVISORS LLC |
215,809 |
1,798,000 |
1.02% |
|
|
| 24 |
Bank of New York Mellon Corp |
174,674 |
1,455,000 |
0.82% |
|
|
| 25 |
FIL Ltd |
169,496 |
1,412,000 |
0.80% |
|
|
| 26 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
156,261 |
1,302,000 |
0.74% |
|
|
| 27 |
GEODE CAPITAL MANAGEMENT, LLC |
125,896 |
1,048,000 |
0.59% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
97,411 |
811,000 |
0.46% |
|
|
| 29 |
BlackRock Investment Management, LLC |
75,511 |
629,000 |
0.36% |
|
|
| 30 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
75,000 |
625,000 |
0.35% |
|
|
| 31 |
COMMERCE BANK |
65,958 |
549,000 |
0.31% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
62,058 |
516,000 |
0.29% |
|
|
| 33 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
471,000 |
0.27% |
|
|
| 34 |
ROYCE & ASSOCIATES LP |
55,000 |
458,000 |
0.26% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,622 |
347,000 |
0.20% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
38,500 |
321,000 |
0.18% |
Put |
|
| 37 |
MILLENNIUM MANAGEMENT LLC |
31,085 |
259,000 |
0.15% |
|
|
| 38 |
TFS CAPITAL LLC |
31,000 |
258,000 |
0.15% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
30,694 |
256,000 |
0.15% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,500 |
238,000 |
0.13% |
|
|
| 41 |
GOLDMAN SACHS GROUP INC |
28,085 |
234,000 |
0.13% |
|
|
| 42 |
RHUMBLINE ADVISERS |
25,074 |
209,000 |
0.12% |
|
|
| 43 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
24,796 |
207,000 |
0.12% |
|
|
| 44 |
UBS AG |
21,529 |
180,000 |
0.10% |
|
|
| 45 |
IRIDIAN ASSET MANAGEMENT LLC/CT |
21,240 |
177,000 |
0.10% |
|
|
| 46 |
MORGAN STANLEY |
17,447 |
146,000 |
0.08% |
|
|
| 47 |
Nationwide Fund Advisors |
17,390 |
145,000 |
0.08% |
|
|
| 48 |
METROPOLITAN LIFE INSURANCE CO/NY |
17,034 |
142,000 |
0.08% |
|
|
| 49 |
PEAK6 Group LLC |
16,746 |
139,000 |
0.08% |
|
|
| 50 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
16,519 |
138,000 |
0.08% |
|
|
