| 1 |
BAKER BROS. ADVISORS LP |
3,537,137 |
32,931,000 |
16.69% |
|
|
| 2 |
FMR LLC |
1,951,400 |
18,168,000 |
9.21% |
|
|
| 3 |
Broadfin Capital, LLC |
1,856,877 |
17,288,000 |
8.76% |
|
|
| 4 |
Consonance Capital Management LP |
1,632,627 |
15,200,000 |
7.70% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
1,185,632 |
11,038,000 |
5.59% |
|
|
| 6 |
Senvest Management, LLC |
1,151,926 |
10,724,000 |
5.43% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
1,136,666 |
10,582,000 |
5.36% |
|
|
| 8 |
HealthCor Management, L.P. |
920,000 |
8,565,000 |
4.34% |
|
|
| 9 |
JPMORGAN CHASE & CO |
774,357 |
7,209,000 |
3.65% |
|
|
| 10 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
721,546 |
6,718,000 |
3.40% |
|
|
| 11 |
BlackRock Fund Advisors |
617,699 |
5,751,000 |
2.91% |
|
|
| 12 |
VANGUARD GROUP INC |
543,641 |
5,061,000 |
2.56% |
|
|
| 13 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
460,370 |
4,286,000 |
2.17% |
|
|
| 14 |
DAFNA Capital Management LLC |
384,794 |
3,582,000 |
1.81% |
|
|
| 15 |
J. Goldman & Co LP |
365,000 |
3,398,000 |
1.72% |
|
|
| 16 |
Granahan Investment Management, LLC |
329,202 |
3,065,000 |
1.55% |
|
|
| 17 |
PERCEPTIVE ADVISORS LLC |
313,583 |
2,919,000 |
1.48% |
|
|
| 18 |
ORBIMED ADVISORS LLC |
300,000 |
2,793,000 |
1.42% |
|
|
| 19 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
265,946 |
2,476,000 |
1.25% |
|
|
| 20 |
STATE STREET CORP |
251,906 |
2,346,000 |
1.19% |
|
|
| 21 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
249,204 |
2,320,000 |
1.18% |
|
|
| 22 |
NORTHERN TRUST CORP |
240,657 |
2,240,000 |
1.13% |
|
|
| 23 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
234,442 |
2,183,000 |
1.11% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
225,888 |
2,103,000 |
1.07% |
|
|
| 25 |
Bank of New York Mellon Corp |
179,508 |
1,672,000 |
0.85% |
|
|
| 26 |
FIL Ltd |
169,496 |
1,578,000 |
0.80% |
|
|
| 27 |
ROYCE & ASSOCIATES LP |
162,100 |
1,509,000 |
0.76% |
|
|
| 28 |
GEODE CAPITAL MANAGEMENT, LLC |
128,504 |
1,196,000 |
0.61% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
96,043 |
894,000 |
0.45% |
|
|
| 30 |
BlackRock Investment Management, LLC |
75,613 |
704,000 |
0.36% |
|
|
| 31 |
PEAK6 Group LLC |
75,305 |
701,000 |
0.36% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
71,009 |
660,000 |
0.33% |
|
|
| 33 |
COMMERCE BANK |
65,958 |
614,000 |
0.31% |
|
|
| 34 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
491,000 |
0.25% |
|
|
| 35 |
MILLENNIUM MANAGEMENT LLC |
46,279 |
431,000 |
0.22% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,801 |
389,000 |
0.20% |
|
|
| 37 |
D. E. Shaw & Co., Inc. |
38,497 |
358,000 |
0.18% |
|
|
| 38 |
PEAK6 Group LLC |
31,800 |
296,000 |
0.15% |
Put |
|
| 39 |
TEACHERS ADVISORS, LLC |
3,525,065 |
286,000 |
0.14% |
|
|
| 40 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,500 |
266,000 |
0.13% |
|
|
| 41 |
RHUMBLINE ADVISERS |
27,674 |
258,000 |
0.13% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,600 |
238,000 |
0.12% |
Put |
|
| 43 |
UBS Group AG |
20,338 |
189,000 |
0.10% |
|
|
| 44 |
GOLDMAN SACHS GROUP INC |
17,503 |
163,000 |
0.08% |
|
|
| 45 |
Nationwide Fund Advisors |
17,390 |
162,000 |
0.08% |
|
|
| 46 |
METROPOLITAN LIFE INSURANCE CO/NY |
17,034 |
159,000 |
0.08% |
|
|
| 47 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
16,519 |
154,000 |
0.08% |
|
|
| 48 |
RENAISSANCE TECHNOLOGIES LLC |
15,623 |
145,000 |
0.07% |
|
|
| 49 |
AMERICAN INTERNATIONAL GROUP, INC. |
15,238 |
141,866 |
0.07% |
|
|
| 50 |
IRIDIAN ASSET MANAGEMENT LLC/CT |
14,850 |
138,000 |
0.07% |
|
|
