| 1 |
BAKER BROS. ADVISORS LP |
3,752,390 |
19,512,000 |
22.38% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,667,600 |
13,872,000 |
15.91% |
|
|
| 3 |
Broadfin Capital, LLC |
2,562,104 |
13,323,000 |
15.28% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
1,412,577 |
7,345,000 |
8.43% |
|
|
| 5 |
Granahan Investment Management, LLC |
1,148,970 |
5,975,000 |
6.85% |
|
|
| 6 |
Krensavage Asset Management, LLC |
891,026 |
4,633,000 |
5.32% |
|
|
| 7 |
VANGUARD GROUP INC |
843,287 |
4,385,000 |
5.03% |
|
|
| 8 |
RENAISSANCE TECHNOLOGIES LLC |
629,600 |
3,274,000 |
3.76% |
|
|
| 9 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
624,154 |
3,246,000 |
3.72% |
|
|
| 10 |
ROYCE & ASSOCIATES LP |
549,341 |
2,857,000 |
3.28% |
|
|
| 11 |
DAFNA Capital Management LLC |
353,718 |
1,839,000 |
2.11% |
|
|
| 12 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
227,704 |
1,184,000 |
1.36% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
145,577 |
757,000 |
0.87% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
127,650 |
663,000 |
0.76% |
|
|
| 15 |
Connor, Clark & Lunn Investment Management Ltd. |
75,200 |
391,000 |
0.45% |
|
|
| 16 |
DIMENSIONAL FUND ADVISORS LP |
72,997 |
380,000 |
0.44% |
|
|
| 17 |
OBERWEIS ASSET MANAGEMENT INC/ |
70,000 |
364,000 |
0.42% |
|
|
| 18 |
NORTHERN TRUST CORP |
62,601 |
326,000 |
0.37% |
|
|
| 19 |
BlackRock Fund Advisors |
56,718 |
295,000 |
0.34% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
294,000 |
0.34% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
54,236 |
282,000 |
0.32% |
|
|
| 22 |
D. E. Shaw & Co., Inc. |
49,791 |
259,000 |
0.30% |
|
|
| 23 |
COMMERCE BANK |
48,958 |
255,000 |
0.29% |
|
|
| 24 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
39,267 |
204,000 |
0.23% |
|
|
| 25 |
CONNORS INVESTOR SERVICES INC |
22,625 |
118,000 |
0.14% |
|
|
| 26 |
TFS CAPITAL LLC |
19,010 |
99,000 |
0.11% |
|
|
| 27 |
Bank of New York Mellon Corp |
18,625 |
97,000 |
0.11% |
|
|
| 28 |
PANAGORA ASSET MANAGEMENT INC |
18,405 |
96,000 |
0.11% |
|
|
| 29 |
BlackRock Group LTD |
17,274 |
90,000 |
0.10% |
|
|
| 30 |
Brandywine Global Investment Management, LLC |
13,910 |
73,000 |
0.08% |
|
|
| 31 |
BANK OF AMERICA CORP /DE/ |
13,943 |
73,000 |
0.08% |
|
|
| 32 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
12,633 |
66,000 |
0.08% |
|
|
| 33 |
MORGAN STANLEY |
12,257 |
64,000 |
0.07% |
|
|
| 34 |
Commonwealth Equity Services, Inc |
12,100 |
63,000 |
0.07% |
|
|
| 35 |
PNC FINANCIAL SERVICES GROUP, INC. |
12,000 |
62,000 |
0.07% |
|
|
| 36 |
STATE STREET CORP |
11,858 |
62,000 |
0.07% |
|
|
| 37 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
11,320 |
59,000 |
0.07% |
|
|
| 38 |
BLACKROCK ADVISORS LLC |
7,068 |
37,000 |
0.04% |
|
|
| 39 |
Nationwide Fund Advisors |
6,892 |
36,000 |
0.04% |
|
|
| 40 |
UBS Group AG |
6,599 |
34,000 |
0.04% |
|
|
| 41 |
RUSSELL INVESTMENTS GROUP, LTD. |
6,352 |
33,000 |
0.04% |
|
|
| 42 |
VALLEY NATIONAL ADVISERS INC |
5,000 |
26,000 |
0.03% |
|
|
| 43 |
Segantii Capital Management Ltd |
4,900 |
25,000 |
0.03% |
|
|
| 44 |
BlackRock Investment Management, LLC |
3,494 |
18,000 |
0.02% |
|
|
| 45 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,000 |
5,000 |
0.01% |
|
|
| 46 |
DEUTSCHE BANK AG\ |
1,104 |
5,000 |
0.01% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
627 |
3,000 |
0.00% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
524 |
3,000 |
0.00% |
|
|
| 49 |
Plante Moran Financial Advisors, LLC |
669 |
3,000 |
0.00% |
|
|
| 50 |
SIMPLEX TRADING, LLC |
278 |
1,000 |
0.00% |
|
|
