| 1 |
BAKER BROS. ADVISORS LP |
3,457,841 |
29,288,000 |
16.02% |
|
|
| 2 |
Broadfin Capital, LLC |
2,130,477 |
18,045,000 |
9.87% |
|
|
| 3 |
FMR LLC |
1,951,200 |
16,527,000 |
9.04% |
|
|
| 4 |
Consonance Capital Management LP |
1,632,627 |
13,828,000 |
7.56% |
|
|
| 5 |
Senvest Management, LLC |
1,151,926 |
9,757,000 |
5.34% |
|
|
| 6 |
JENNISON ASSOCIATES LLC |
1,136,928 |
9,630,000 |
5.27% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
991,040 |
8,394,000 |
4.59% |
|
|
| 8 |
GREAT POINT PARTNERS LLC |
977,923 |
8,283,000 |
4.53% |
|
|
| 9 |
HealthCor Management, L.P. |
893,600 |
7,569,000 |
4.14% |
|
|
| 10 |
J. Goldman & Co LP |
772,649 |
6,544,000 |
3.58% |
|
|
| 11 |
BlackRock Fund Advisors |
619,345 |
5,246,000 |
2.87% |
|
|
| 12 |
VANGUARD GROUP INC |
582,976 |
4,938,000 |
2.70% |
|
|
| 13 |
DAFNA Capital Management LLC |
373,918 |
3,167,000 |
1.73% |
|
SH |
| 14 |
PERCEPTIVE ADVISORS LLC |
343,284 |
2,908,000 |
1.59% |
|
|
| 15 |
ROYCE & ASSOCIATES LP |
342,600 |
2,902,000 |
1.59% |
|
|
| 16 |
ORBIMED ADVISORS LLC |
300,000 |
2,541,000 |
1.39% |
|
|
| 17 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
275,000 |
2,329,000 |
1.27% |
|
|
| 18 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
268,814 |
2,277,000 |
1.25% |
|
|
| 19 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
266,896 |
2,261,000 |
1.24% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
264,385 |
2,239,000 |
1.22% |
|
|
| 21 |
STATE STREET CORP |
260,766 |
2,205,000 |
1.21% |
|
|
| 22 |
Granahan Investment Management, LLC |
247,520 |
2,096,000 |
1.15% |
|
|
| 23 |
NORTHERN TRUST CORP |
227,802 |
1,929,000 |
1.06% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
225,474 |
1,910,000 |
1.04% |
|
|
| 25 |
JPMORGAN CHASE & CO |
224,716 |
1,903,000 |
1.04% |
|
|
| 26 |
Bank of New York Mellon Corp |
184,442 |
1,563,000 |
0.86% |
|
|
| 27 |
FIL Ltd |
169,496 |
1,436,000 |
0.79% |
|
|
| 28 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
154,351 |
1,307,000 |
0.71% |
|
|
| 29 |
RENAISSANCE TECHNOLOGIES LLC |
141,608 |
1,199,000 |
0.66% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
135,512 |
1,147,000 |
0.63% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
96,043 |
813,000 |
0.44% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
93,865 |
794,000 |
0.43% |
|
|
| 33 |
PEAK6 Group LLC |
85,296 |
722,000 |
0.39% |
|
|
| 34 |
BlackRock Investment Management, LLC |
76,216 |
646,000 |
0.35% |
|
|
| 35 |
COMMERCE BANK |
65,958 |
559,000 |
0.31% |
|
|
| 36 |
D. E. Shaw & Co., Inc. |
62,306 |
528,000 |
0.29% |
|
|
| 37 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
491,000 |
0.27% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,801 |
354,000 |
0.19% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
30,694 |
260,000 |
0.14% |
|
|
| 40 |
RHUMBLINE ADVISERS |
29,174 |
247,000 |
0.14% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,500 |
242,000 |
0.13% |
|
|
| 42 |
PEAK6 Group LLC |
27,400 |
232,000 |
0.13% |
Put |
|
| 43 |
DIMENSIONAL FUND ADVISORS LP |
19,736 |
167,000 |
0.09% |
|
|
| 44 |
IRIDIAN ASSET MANAGEMENT LLC/CT |
17,340 |
147,000 |
0.08% |
|
|
| 45 |
GOLDMAN SACHS GROUP INC |
17,045 |
144,000 |
0.08% |
|
|
| 46 |
Nationwide Fund Advisors |
16,599 |
141,000 |
0.08% |
|
|
| 47 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
16,519 |
140,000 |
0.08% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
15,238 |
129,066 |
0.07% |
|
|
| 49 |
Commonwealth Equity Services, Inc |
13,106 |
111,000 |
0.06% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
10,752 |
91,000 |
0.05% |
|
|
