| 1 |
BAKER BROS. ADVISORS LP |
3,752,390 |
11,632,000 |
19.98% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,684,500 |
8,322,000 |
14.30% |
|
|
| 3 |
Broadfin Capital, LLC |
2,562,104 |
7,943,000 |
13.64% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
1,414,487 |
4,385,000 |
7.53% |
|
|
| 5 |
Granahan Investment Management, LLC |
1,028,460 |
3,188,000 |
5.48% |
|
|
| 6 |
Krensavage Asset Management, LLC |
906,046 |
2,809,000 |
4.83% |
|
|
| 7 |
VANGUARD GROUP INC |
794,502 |
2,463,000 |
4.23% |
|
|
| 8 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
595,005 |
1,845,000 |
3.17% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
541,800 |
1,680,000 |
2.89% |
|
|
| 10 |
STONEPINE CAPITAL MANAGEMENT, LLC |
507,799 |
1,574,000 |
2.70% |
|
|
| 11 |
Senvest Management, LLC |
489,807 |
1,518,000 |
2.61% |
|
|
| 12 |
PERCEPTIVE ADVISORS LLC |
432,884 |
1,341,000 |
2.30% |
|
|
| 13 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
400,000 |
1,240,000 |
2.13% |
|
|
| 14 |
DAFNA Capital Management LLC |
353,718 |
1,097,000 |
1.88% |
|
|
| 15 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
342,439 |
1,062,000 |
1.82% |
|
|
| 16 |
D. E. Shaw & Co., Inc. |
324,713 |
1,007,000 |
1.73% |
|
|
| 17 |
ROYCE & ASSOCIATES LP |
237,507 |
736,000 |
1.26% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
149,439 |
463,000 |
0.80% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
129,697 |
401,000 |
0.69% |
|
|
| 20 |
ROANOKE ASSET MANAGEMENT CORP/ NY |
124,549 |
386,000 |
0.66% |
|
|
| 21 |
OXFORD ASSET MANAGEMENT LLP |
124,344 |
385,000 |
0.66% |
|
|
| 22 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
117,271 |
364,000 |
0.63% |
|
|
| 23 |
RA CAPITAL MANAGEMENT, L.P. |
81,239 |
252,000 |
0.43% |
|
|
| 24 |
CREDIT SUISSE AG/ |
58,299 |
181,000 |
0.31% |
|
|
| 25 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
175,000 |
0.30% |
|
|
| 26 |
BlackRock Fund Advisors |
55,351 |
172,000 |
0.30% |
|
|
| 27 |
RUSSELL FRANK CO/ |
54,954 |
170,000 |
0.29% |
|
|
| 28 |
NORTHERN TRUST CORP |
52,471 |
163,000 |
0.28% |
|
|
| 29 |
COMMERCE BANK |
48,958 |
152,000 |
0.26% |
|
|
| 30 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
49,035 |
152,000 |
0.26% |
|
|
| 31 |
DIMENSIONAL FUND ADVISORS LP |
45,449 |
141,000 |
0.24% |
|
|
| 32 |
Connor, Clark & Lunn Investment Management Ltd. |
36,100 |
112,000 |
0.19% |
|
|
| 33 |
Nationwide Fund Advisors |
35,139 |
109,000 |
0.19% |
|
|
| 34 |
GOLDMAN SACHS GROUP INC |
29,575 |
92,000 |
0.16% |
|
|
| 35 |
Bank of New York Mellon Corp |
23,163 |
71,000 |
0.12% |
|
|
| 36 |
MILLENNIUM MANAGEMENT LLC |
20,981 |
65,000 |
0.11% |
|
|
| 37 |
BlackRock Group LTD |
17,274 |
54,000 |
0.09% |
|
|
| 38 |
STATE STREET CORP |
15,658 |
49,000 |
0.08% |
|
|
| 39 |
Commonwealth Equity Services, Inc |
14,850 |
46,000 |
0.08% |
|
|
| 40 |
PEAK6 Group LLC |
11,100 |
34,000 |
0.06% |
Put |
|
| 41 |
BANK OF AMERICA CORP /DE/ |
9,944 |
31,000 |
0.05% |
|
|
| 42 |
MORGAN STANLEY |
7,352 |
23,000 |
0.04% |
|
|
| 43 |
UBS Group AG |
7,550 |
23,000 |
0.04% |
|
|
| 44 |
PEAK6 Group LLC |
5,974 |
19,000 |
0.03% |
|
|
| 45 |
VALLEY NATIONAL ADVISERS INC |
5,000 |
16,000 |
0.03% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
4,427 |
14,000 |
0.02% |
|
|
| 47 |
Tower Research Capital LLC (TRC) |
4,570 |
14,000 |
0.02% |
|
|
| 48 |
BlackRock Investment Management, LLC |
3,882 |
12,000 |
0.02% |
|
|
| 49 |
SIMPLEX TRADING, LLC |
3,518 |
10,000 |
0.02% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
2,182 |
7,000 |
0.01% |
|
|
