| 1 |
BAKER BROS. ADVISORS LP |
3,752,390 |
14,784,000 |
21.23% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,684,500 |
10,577,000 |
15.19% |
|
|
| 3 |
Broadfin Capital, LLC |
2,562,104 |
10,095,000 |
14.50% |
|
|
| 4 |
JENNISON ASSOCIATES LLC |
1,413,534 |
5,569,000 |
8.00% |
|
|
| 5 |
Granahan Investment Management, LLC |
1,001,360 |
3,945,000 |
5.66% |
|
|
| 6 |
Krensavage Asset Management, LLC |
910,703 |
3,588,000 |
5.15% |
|
|
| 7 |
VANGUARD GROUP INC |
802,878 |
3,163,000 |
4.54% |
|
|
| 8 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
689,446 |
2,716,000 |
3.90% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
579,700 |
2,284,000 |
3.28% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
432,884 |
1,706,000 |
2.45% |
|
|
| 11 |
DAFNA Capital Management LLC |
353,718 |
1,394,000 |
2.00% |
|
SH |
| 12 |
D. E. Shaw & Co., Inc. |
319,319 |
1,258,000 |
1.81% |
|
|
| 13 |
STONEPINE CAPITAL MANAGEMENT, LLC |
283,306 |
1,116,000 |
1.60% |
|
|
| 14 |
ROYCE & ASSOCIATES LP |
232,521 |
916,000 |
1.32% |
|
|
| 15 |
Senvest Management, LLC |
228,336 |
900,000 |
1.29% |
|
|
| 16 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
199,816 |
787,000 |
1.13% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
153,052 |
603,000 |
0.87% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
127,210 |
501,000 |
0.72% |
|
|
| 19 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
109,327 |
431,000 |
0.62% |
|
|
| 20 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
92,372 |
364,000 |
0.52% |
|
|
| 21 |
OXFORD ASSET MANAGEMENT LLP |
77,176 |
304,000 |
0.44% |
|
|
| 22 |
NORTHERN TRUST CORP |
59,311 |
234,000 |
0.34% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
56,500 |
223,000 |
0.32% |
|
|
| 24 |
BlackRock Fund Advisors |
54,495 |
215,000 |
0.31% |
|
|
| 25 |
DIMENSIONAL FUND ADVISORS LP |
52,535 |
207,000 |
0.30% |
|
|
| 26 |
EMERALD ACQUISITION LTD. |
51,454 |
202,000 |
0.29% |
|
|
| 27 |
Connor, Clark & Lunn Investment Management Ltd. |
50,400 |
199,000 |
0.29% |
|
|
| 28 |
CREDIT SUISSE AG/ |
50,120 |
197,000 |
0.28% |
|
|
| 29 |
COMMERCE BANK |
48,958 |
193,000 |
0.28% |
|
|
| 30 |
GOLDMAN SACHS GROUP INC |
34,096 |
134,000 |
0.19% |
|
|
| 31 |
Nationwide Fund Advisors |
32,708 |
129,000 |
0.19% |
|
|
| 32 |
ALAMBIC INVESTMENT MANAGEMENT, L.P. |
27,620 |
109,000 |
0.16% |
|
|
| 33 |
Bank of New York Mellon Corp |
23,063 |
91,000 |
0.13% |
|
|
| 34 |
C M BIDWELL & ASSOCIATES LTD |
22,865 |
90,000 |
0.13% |
|
|
| 35 |
BlackRock Group LTD |
17,274 |
68,000 |
0.10% |
|
|
| 36 |
Commonwealth Equity Services, Inc |
14,850 |
59,000 |
0.08% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
13,459 |
53,000 |
0.08% |
|
|
| 38 |
STATE STREET CORP |
11,858 |
48,000 |
0.07% |
|
|
| 39 |
UBS Group AG |
9,731 |
39,000 |
0.06% |
|
|
| 40 |
WOLVERINE TRADING LP /BD |
7,916 |
30,477 |
0.04% |
|
|
| 41 |
Walleye Trading LLC |
5,800 |
23,000 |
0.03% |
|
|
| 42 |
VALLEY NATIONAL ADVISERS INC |
5,000 |
20,000 |
0.03% |
|
|
| 43 |
WOLVERINE TRADING LP /BD |
40 |
15,400 |
0.02% |
Call |
|
| 44 |
BlackRock Investment Management, LLC |
3,494 |
14,000 |
0.02% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
2,182 |
9,000 |
0.01% |
|
|
| 46 |
MORGAN STANLEY |
2,043 |
8,000 |
0.01% |
|
|
| 47 |
BARCLAYS PLC |
1,999 |
8,000 |
0.01% |
|
|
| 48 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,657 |
7,000 |
0.01% |
|
|
| 49 |
WOLVERINE TRADING LP /BD |
16 |
6,160 |
0.01% |
Put |
|
| 50 |
DEUTSCHE BANK AG\ |
1,250 |
4,000 |
0.01% |
|
|
