| 1 |
FMR LLC |
2,087,440 |
58,532,000 |
18.14% |
|
|
| 2 |
Aisling Capital LLC |
1,994,568 |
55,928,000 |
17.34% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
1,203,002 |
50,107,000 |
15.53% |
|
|
| 4 |
BAKER BROS. ADVISORS LP |
1,245,889 |
34,935,000 |
10.83% |
|
|
| 5 |
HealthCor Management, L.P. |
650,000 |
18,226,000 |
5.65% |
|
|
| 6 |
JPMORGAN CHASE & CO |
417,646 |
11,711,000 |
3.63% |
|
|
| 7 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
379,200 |
10,629,000 |
3.29% |
|
|
| 8 |
PFM Health Sciences, LP |
377,431 |
10,583,000 |
3.28% |
|
|
| 9 |
FEDERATED HERMES, INC. |
323,966 |
9,084,000 |
2.82% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
315,796 |
8,855,000 |
2.74% |
|
|
| 11 |
PRICE T ROWE ASSOCIATES INC /MD/ |
267,500 |
7,501,000 |
2.33% |
|
|
| 12 |
GOLDMAN SACHS GROUP INC |
211,440 |
5,929,000 |
1.84% |
|
|
| 13 |
Cormorant Asset Management, LP |
200,000 |
5,608,000 |
1.74% |
|
|
| 14 |
BlackRock Fund Advisors |
170,587 |
4,783,000 |
1.48% |
|
|
| 15 |
VANGUARD GROUP INC |
147,992 |
4,150,000 |
1.29% |
|
|
| 16 |
Rock Springs Capital Management LP |
124,255 |
3,484,000 |
1.08% |
|
|
| 17 |
MORGAN STANLEY |
98,539 |
2,763,000 |
0.86% |
|
|
| 18 |
STATE STREET CORP |
64,701 |
1,815,000 |
0.56% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
63,139 |
1,770,000 |
0.55% |
|
|
| 20 |
WELLINGTON MANAGEMENT GROUP LLP |
62,850 |
1,762,000 |
0.55% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
57,531 |
1,613,000 |
0.50% |
|
|
| 22 |
JENNISON ASSOCIATES LLC |
50,063 |
1,404,000 |
0.44% |
|
|
| 23 |
EVENTIDE ASSET MANAGEMENT, LLC |
50,000 |
1,402,000 |
0.43% |
|
|
| 24 |
PRINCIPAL FINANCIAL GROUP INC |
43,107 |
1,209,000 |
0.37% |
|
|
| 25 |
Tygh Capital Management, Inc. |
42,589 |
1,194,000 |
0.37% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
26,308 |
738,000 |
0.23% |
|
|
| 27 |
Bank of New York Mellon Corp |
25,992 |
728,000 |
0.23% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
22,181 |
622,000 |
0.19% |
|
|
| 29 |
BlackRock Investment Management, LLC |
19,800 |
555,000 |
0.17% |
|
|
| 30 |
NORGES BANK |
19,200 |
538,000 |
0.17% |
|
|
| 31 |
NORTHERN TRUST CORP |
18,103 |
508,000 |
0.16% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
15,320 |
430,000 |
0.13% |
|
|
| 33 |
Partner Investment Management, L.P. |
14,199 |
398,000 |
0.12% |
|
|
| 34 |
Weiss Multi-Strategy Advisers LLC |
13,000 |
365,000 |
0.11% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,700 |
356,000 |
0.11% |
|
|
| 36 |
BANQUE PICTET & CIE SA |
12,570 |
352,000 |
0.11% |
|
|
| 37 |
PDT Partners, LLC |
11,685 |
328,000 |
0.10% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
9,682 |
271,000 |
0.08% |
|
|
| 39 |
JANE STREET GROUP, LLC |
9,596 |
269,000 |
0.08% |
|
|
| 40 |
METROPOLITAN LIFE INSURANCE CO/NY |
8,723 |
245,000 |
0.08% |
|
|
| 41 |
Board of Trustees of The Leland Stanford Junior University |
7,561 |
212,000 |
0.07% |
|
|
| 42 |
Tower Research Capital LLC (TRC) |
5,857 |
164,000 |
0.05% |
|
|
| 43 |
Nationwide Fund Advisors |
5,227 |
147,000 |
0.05% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
4,677 |
131,000 |
0.04% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,533 |
127,105 |
0.04% |
|
|
| 46 |
ALLIANCEBERNSTEIN L.P. |
2,700 |
76,000 |
0.02% |
|
|
| 47 |
MAZAMA CAPITAL MANAGEMENT INC |
1,185 |
33,000 |
0.01% |
|
|
| 48 |
VIRTUS CAPITAL ADVISERS, LLC |
591 |
17,000 |
0.01% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
493 |
14,000 |
0.00% |
|
|
| 50 |
BlackRock Japan Co. Ltd |
213 |
6,000 |
0.00% |
|
|
