| 1 |
FMR LLC |
3,611,036 |
39,938,000 |
17.69% |
|
|
| 2 |
PERCEPTIVE ADVISORS LLC |
2,835,754 |
31,363,000 |
13.89% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
2,723,399 |
30,121,000 |
13.34% |
|
|
| 4 |
Aisling Capital LLC |
2,279,568 |
25,212,000 |
11.17% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
2,039,223 |
22,554,000 |
9.99% |
|
|
| 6 |
FEDERATED HERMES, INC. |
1,082,150 |
11,969,000 |
5.30% |
|
|
| 7 |
BlackRock Fund Advisors |
1,078,025 |
11,923,000 |
5.28% |
|
|
| 8 |
JPMORGAN CHASE & CO |
856,524 |
9,473,000 |
4.20% |
|
|
| 9 |
VANGUARD GROUP INC |
689,449 |
7,626,000 |
3.38% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
432,025 |
4,778,000 |
2.12% |
|
|
| 11 |
STATE STREET CORP |
355,893 |
3,935,000 |
1.74% |
|
|
| 12 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
316,244 |
3,498,000 |
1.55% |
|
|
| 13 |
NORTHERN TRUST CORP |
304,935 |
3,372,000 |
1.49% |
|
|
| 14 |
ArrowMark Colorado Holdings LLC |
241,603 |
2,672,000 |
1.18% |
|
|
| 15 |
PRINCIPAL FINANCIAL GROUP INC |
186,705 |
2,065,000 |
0.91% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
146,587 |
1,621,000 |
0.72% |
|
|
| 17 |
BlackRock Investment Management, LLC |
113,158 |
1,252,000 |
0.55% |
|
|
| 18 |
Bank of New York Mellon Corp |
106,565 |
1,178,000 |
0.52% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
102,888 |
1,138,000 |
0.50% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
88,837 |
983,000 |
0.44% |
|
|
| 21 |
OXFORD ASSET MANAGEMENT LLP |
80,989 |
896,000 |
0.40% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
69,323 |
767,000 |
0.34% |
|
|
| 23 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
57,295 |
634,000 |
0.28% |
|
|
| 24 |
Nationwide Fund Advisors |
56,765 |
628,000 |
0.28% |
|
|
| 25 |
EMERALD ACQUISITION LTD. |
49,500 |
547,000 |
0.24% |
|
|
| 26 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
47,728 |
528,000 |
0.23% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
43,795 |
484,000 |
0.21% |
|
|
| 28 |
ROYCE & ASSOCIATES LP |
39,592 |
438,000 |
0.19% |
|
|
| 29 |
Swiss National Bank |
35,400 |
392,000 |
0.17% |
|
|
| 30 |
RHUMBLINE ADVISERS |
27,781 |
307,000 |
0.14% |
|
|
| 31 |
D. E. Shaw & Co., Inc. |
26,051 |
288,000 |
0.13% |
|
|
| 32 |
ProShare Advisors LLC |
25,250 |
279,000 |
0.12% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
20,821 |
230,000 |
0.10% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,500 |
227,000 |
0.10% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
20,554 |
227,000 |
0.10% |
|
|
| 36 |
DIMENSIONAL FUND ADVISORS LP |
20,388 |
225,000 |
0.10% |
|
|
| 37 |
CREDIT SUISSE AG/ |
19,987 |
222,000 |
0.10% |
|
|
| 38 |
METROPOLITAN LIFE INSURANCE CO/NY |
18,987 |
210,000 |
0.09% |
|
|
| 39 |
A.R.T. Advisors, LLC |
17,547 |
194,000 |
0.09% |
|
|
| 40 |
AMERICAN INTERNATIONAL GROUP, INC. |
15,729 |
173,963 |
0.08% |
|
|
| 41 |
ALLIANCEBERNSTEIN L.P. |
12,800 |
142,000 |
0.06% |
|
|
| 42 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
12,500 |
138,000 |
0.06% |
|
|
| 43 |
VOYA INVESTMENT MANAGEMENT LLC |
11,866 |
131,000 |
0.06% |
|
|
| 44 |
BLACKROCK ADVISORS LLC |
11,631 |
129,000 |
0.06% |
|
|
| 45 |
CITIGROUP INC |
10,956 |
121,000 |
0.05% |
|
|
| 46 |
DEUTSCHE BANK AG\ |
6,976 |
76,000 |
0.03% |
|
|
| 47 |
BlackRock Finance, Inc. |
6,347 |
70,000 |
0.03% |
|
|
| 48 |
MORGAN STANLEY |
5,934 |
65,000 |
0.03% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
5,540 |
61,000 |
0.03% |
|
|
| 50 |
Legal & General Group Plc |
4,502 |
49,000 |
0.02% |
|
|
