| 1 |
FMR LLC |
4,090,631 |
50,110,000 |
16.76% |
|
|
| 2 |
PERCEPTIVE ADVISORS LLC |
4,028,685 |
49,351,000 |
16.51% |
|
|
| 3 |
Aisling Capital LLC |
2,524,465 |
30,925,000 |
10.34% |
|
|
| 4 |
BAKER BROS. ADVISORS LP |
2,134,247 |
26,145,000 |
8.74% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
2,039,223 |
24,980,000 |
8.35% |
|
|
| 6 |
FEDERATED HERMES, INC. |
1,483,297 |
18,171,000 |
6.08% |
|
|
| 7 |
BlackRock Fund Advisors |
1,151,924 |
14,111,000 |
4.72% |
|
|
| 8 |
JPMORGAN CHASE & CO |
831,929 |
10,192,000 |
3.41% |
|
|
| 9 |
VANGUARD GROUP INC |
812,394 |
9,952,000 |
3.33% |
|
|
| 10 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
481,056 |
5,893,000 |
1.97% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
441,776 |
5,412,000 |
1.81% |
|
|
| 12 |
STATE STREET CORP |
379,266 |
4,646,000 |
1.55% |
|
|
| 13 |
NORTHERN TRUST CORP |
310,066 |
3,798,000 |
1.27% |
|
|
| 14 |
ArrowMark Colorado Holdings LLC |
283,956 |
3,478,000 |
1.16% |
|
|
| 15 |
ARDSLEY ADVISORY PARTNERS LP |
275,000 |
3,369,000 |
1.13% |
|
|
| 16 |
NF TRINITY CAPITAL (HONG KONG) LTD |
244,897 |
3,000,000 |
1.00% |
|
|
| 17 |
COWEN INC. |
205,892 |
2,522,000 |
0.84% |
|
|
| 18 |
Alyeska Investment Group, L.P. |
205,000 |
2,511,000 |
0.84% |
|
|
| 19 |
SPHERA FUNDS MANAGEMENT LTD. |
200,000 |
2,450,000 |
0.82% |
|
|
| 20 |
PRINCIPAL FINANCIAL GROUP INC |
185,500 |
2,272,000 |
0.76% |
|
|
| 21 |
SABBY MANAGEMENT, LLC |
174,968 |
2,143,000 |
0.72% |
|
|
| 22 |
MONASHEE INVESTMENT MANAGEMENT LLC |
150,000 |
1,838,000 |
0.61% |
|
PRN |
| 23 |
Lombard Odier Asset Management (USA) Corp |
150,000 |
1,838,000 |
0.61% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
149,421 |
1,830,000 |
0.61% |
|
|
| 25 |
BlackRock Investment Management, LLC |
112,844 |
1,382,000 |
0.46% |
|
|
| 26 |
Bank of New York Mellon Corp |
105,008 |
1,286,000 |
0.43% |
|
|
| 27 |
Avoro Capital Advisors LLC |
95,742 |
1,173,000 |
0.39% |
|
|
| 28 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
94,000 |
1,152,000 |
0.39% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
86,707 |
1,062,000 |
0.36% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
72,053 |
883,000 |
0.30% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
64,518 |
790,000 |
0.26% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
57,795 |
708,000 |
0.24% |
|
|
| 33 |
Nationwide Fund Advisors |
50,365 |
617,000 |
0.21% |
|
|
| 34 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
47,668 |
584,000 |
0.20% |
|
|
| 35 |
MILLENNIUM MANAGEMENT LLC |
46,212 |
566,000 |
0.19% |
|
|
| 36 |
Swiss National Bank |
44,600 |
546,000 |
0.18% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
43,795 |
536,000 |
0.18% |
|
|
| 38 |
EMERALD ACQUISITION LTD. |
37,339 |
457,000 |
0.15% |
|
|
| 39 |
DIMENSIONAL FUND ADVISORS LP |
34,613 |
424,000 |
0.14% |
|
|
| 40 |
OXFORD ASSET MANAGEMENT LLP |
33,054 |
405,000 |
0.14% |
|
|
| 41 |
NEW YORK STATE COMMON RETIREMENT FUND |
29,600 |
363,000 |
0.12% |
|
|
| 42 |
RHUMBLINE ADVISERS |
29,281 |
359,000 |
0.12% |
|
|
| 43 |
TUDOR INVESTMENT CORP ET AL |
27,788 |
340,000 |
0.11% |
|
|
| 44 |
CITADEL ADVISORS LLC |
25,818 |
316,000 |
0.11% |
|
|
| 45 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
24,426 |
299,000 |
0.10% |
|
|
| 46 |
JANE STREET GROUP, LLC |
24,101 |
295,000 |
0.10% |
|
|
| 47 |
ProShare Advisors LLC |
21,325 |
261,000 |
0.09% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
20,151 |
247,000 |
0.08% |
|
|
| 49 |
METROPOLITAN LIFE INSURANCE CO/NY |
18,987 |
233,000 |
0.08% |
|
|
| 50 |
RENAISSANCE TECHNOLOGIES LLC |
18,900 |
232,000 |
0.08% |
|
|
