| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,394,576 | 50,669,000 | 19.88% | ||
| 2 | BAKER BROS. ADVISORS LP | 3,241,783 | 37,378,000 | 14.67% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 2,317,954 | 26,726,000 | 10.49% | ||
| 4 | Aisling Capital LLC | 2,279,568 | 26,283,000 | 10.31% | ||
| 5 | New Leaf Venture Partners, L.L.C. | 2,039,223 | 23,512,000 | 9.23% | ||
| 6 | FEDERATED HERMES, INC. | 1,326,900 | 15,299,000 | 6.00% | ||
| 7 | BlackRock Fund Advisors | 985,476 | 11,363,000 | 4.46% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 687,484 | 7,927,000 | 3.11% | ||
| 9 | JPMORGAN CHASE & CO | 672,124 | 7,750,000 | 3.04% | ||
| 10 | VANGUARD GROUP INC | 586,827 | 6,766,000 | 2.66% | ||
| 11 | ALPS ADVISORS INC | 45,944 | 5,297,000 | 2.08% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 394,206 | 4,545,000 | 1.78% | ||
| 13 | CITADEL ADVISORS LLC | 341,488 | 3,937,000 | 1.54% | ||
| 14 | STATE STREET CORP | 312,996 | 3,605,000 | 1.41% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 277,000 | 3,194,000 | 1.25% | ||
| 16 | NORTHERN TRUST CORP | 245,715 | 2,833,000 | 1.11% | ||
| 17 | ArrowMark Colorado Holdings LLC | 175,929 | 2,028,000 | 0.80% | ||
| 18 | Cormorant Asset Management, LP | 170,000 | 1,960,000 | 0.77% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 129,870 | 1,497,000 | 0.59% | ||
| 20 | Point72 Asset Management, L.P. | 101,600 | 1,171,000 | 0.46% | ||
| 21 | PRINCIPAL FINANCIAL GROUP INC | 100,030 | 1,153,000 | 0.45% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 88,546 | 1,021,000 | 0.40% | ||
| 23 | BlackRock Investment Management, LLC | 84,691 | 976,000 | 0.38% | ||
| 24 | Bank of New York Mellon Corp | 78,075 | 899,000 | 0.35% | ||
| 25 | ROYCE & ASSOCIATES LP | 62,592 | 722,000 | 0.28% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 54,563 | 630,000 | 0.25% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,986 | 473,000 | 0.19% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 40,409 | 466,000 | 0.18% | ||
| 29 | TEACHERS ADVISORS, LLC | 32,981 | 380,000 | 0.15% | ||
| 30 | RHUMBLINE ADVISERS | 28,367 | 327,000 | 0.13% | ||
| 31 | Swiss National Bank | 27,100 | 312,000 | 0.12% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 24,829 | 286,000 | 0.11% | ||
| 33 | ProShare Advisors LLC | 24,532 | 283,000 | 0.11% | ||
| 34 | NEW YORK STATE COMMON RETIREMENT FUND | 20,500 | 236,000 | 0.09% | ||
| 35 | MORGAN STANLEY | 17,524 | 203,000 | 0.08% | ||
| 36 | AQR CAPITAL MANAGEMENT LLC | 17,334 | 200,000 | 0.08% | ||
| 37 | METROPOLITAN LIFE INSURANCE CO/NY | 16,881 | 195,000 | 0.08% | ||
| 38 | GOLDMAN SACHS GROUP INC | 16,282 | 188,000 | 0.07% | ||
| 39 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,520 | 179,000 | 0.07% | ||
| 40 | DekaBank Deutsche Girozentrale | 14,700 | 169,000 | 0.07% | ||
| 41 | Nationwide Fund Advisors | 14,469 | 167,000 | 0.07% | ||
| 42 | BLACKROCK ADVISORS LLC | 14,052 | 162,000 | 0.06% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 13,198 | 152,000 | 0.06% | ||
| 44 | DIMENSIONAL FUND ADVISORS LP | 12,554 | 145,000 | 0.06% | ||
| 45 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,500 | 144,000 | 0.06% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 12,300 | 142,000 | 0.06% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 11,866 | 137,000 | 0.05% | ||
| 48 | DEUTSCHE BANK AG\ | 10,185 | 116,000 | 0.05% | ||
| 49 | CITIGROUP INC | 9,329 | 108,000 | 0.04% | ||
| 50 | BARCLAYS PLC | 9,607 | 105,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
