| 1 |
FMR LLC |
4,381,735 |
66,690,000 |
21.46% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
3,436,585 |
52,305,000 |
16.83% |
|
|
| 3 |
Aisling Capital LLC |
2,279,568 |
34,695,000 |
11.16% |
|
|
| 4 |
New Leaf Venture Partners, L.L.C. |
2,039,223 |
31,037,000 |
9.99% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
1,321,400 |
20,112,000 |
6.47% |
|
|
| 6 |
FEDERATED HERMES, INC. |
1,160,000 |
17,655,000 |
5.68% |
|
|
| 7 |
BlackRock Fund Advisors |
946,240 |
14,402,000 |
4.63% |
|
|
| 8 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
895,531 |
13,630,000 |
4.39% |
|
|
| 9 |
JPMORGAN CHASE & CO |
574,091 |
8,737,000 |
2.81% |
|
|
| 10 |
Tourbillon Capital Partners, L.P. |
495,000 |
7,534,000 |
2.42% |
|
|
| 11 |
VANGUARD GROUP INC |
470,983 |
7,168,000 |
2.31% |
|
|
| 12 |
STATE STREET CORP |
233,561 |
3,555,000 |
1.14% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
215,226 |
3,276,000 |
1.05% |
|
|
| 14 |
Cormorant Asset Management, LP |
170,000 |
2,587,000 |
0.83% |
|
|
| 15 |
ArrowMark Colorado Holdings LLC |
150,422 |
2,289,000 |
0.74% |
|
|
| 16 |
WELLINGTON MANAGEMENT GROUP LLP |
143,900 |
2,190,000 |
0.70% |
|
|
| 17 |
NORTHERN TRUST CORP |
128,303 |
1,953,000 |
0.63% |
|
|
| 18 |
CREDIT SUISSE AG/ |
127,764 |
1,945,000 |
0.63% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
107,811 |
1,640,000 |
0.53% |
|
|
| 20 |
Ghost Tree Capital, LLC |
100,000 |
1,522,000 |
0.49% |
|
|
| 21 |
PRINCIPAL FINANCIAL GROUP INC |
93,886 |
1,429,000 |
0.46% |
|
|
| 22 |
Bank of New York Mellon Corp |
90,960 |
1,385,000 |
0.45% |
|
|
| 23 |
BlackRock Investment Management, LLC |
84,981 |
1,293,000 |
0.42% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
67,828 |
1,032,000 |
0.33% |
|
|
| 25 |
MORGAN STANLEY |
57,120 |
870,000 |
0.28% |
|
|
| 26 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
51,145 |
779,000 |
0.25% |
|
|
| 27 |
ACUTA CAPITAL PARTNERS, LLC |
50,000 |
761,000 |
0.24% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
45,728 |
696,000 |
0.22% |
|
|
| 29 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,086 |
625,000 |
0.20% |
|
|
| 30 |
CITADEL ADVISORS LLC |
40,946 |
623,000 |
0.20% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
34,524 |
525,000 |
0.17% |
|
|
| 32 |
ALPS ADVISORS INC |
29,030 |
442,000 |
0.14% |
|
|
| 33 |
FRED ALGER MANAGEMENT, LLC |
28,950 |
441,000 |
0.14% |
|
|
| 34 |
RHUMBLINE ADVISERS |
26,730 |
407,000 |
0.13% |
|
|
| 35 |
ProShare Advisors LLC |
26,223 |
399,000 |
0.13% |
|
|
| 36 |
Swiss National Bank |
23,400 |
356,000 |
0.11% |
|
|
| 37 |
CORRADO ADVISORS, LLC |
18,465 |
281,000 |
0.09% |
|
|
| 38 |
GOLDMAN SACHS GROUP INC |
17,170 |
261,000 |
0.08% |
|
|
| 39 |
METROPOLITAN LIFE INSURANCE CO/NY |
16,881 |
257,000 |
0.08% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
16,843 |
256,000 |
0.08% |
|
|
| 41 |
D. E. Shaw & Co., Inc. |
15,443 |
235,000 |
0.08% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
15,184 |
231,000 |
0.07% |
|
|
| 43 |
A.R.T. Advisors, LLC |
14,460 |
220,000 |
0.07% |
|
|
| 44 |
Nationwide Fund Advisors |
14,469 |
220,000 |
0.07% |
|
|
| 45 |
DekaBank Deutsche Girozentrale |
13,900 |
212,000 |
0.07% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
13,636 |
208,000 |
0.07% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,183 |
200,645 |
0.06% |
|
|
| 48 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
12,500 |
190,000 |
0.06% |
|
|
| 49 |
BlackRock Group LTD |
12,059 |
184,000 |
0.06% |
|
|
| 50 |
VOYA INVESTMENT MANAGEMENT LLC |
11,866 |
181,000 |
0.06% |
|
|
