| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,629,221 | 81,476,000 | 21.13% | ||
| 2 | New Leaf Venture Partners, L.L.C. | 2,296,471 | 51,556,000 | 13.37% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,281,744 | 51,225,000 | 13.28% | ||
| 4 | Aisling Capital LLC | 1,994,568 | 44,778,000 | 11.61% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 931,171 | 19,740,000 | 5.12% | ||
| 6 | HealthCor Management, L.P. | 875,000 | 19,644,000 | 5.09% | ||
| 7 | PFM Health Sciences, LP | 869,463 | 19,519,000 | 5.06% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 644,150 | 14,461,000 | 3.75% | ||
| 9 | JPMORGAN CHASE & CO | 517,787 | 11,624,000 | 3.01% | ||
| 10 | BlackRock Fund Advisors | 474,835 | 10,660,000 | 2.76% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 426,700 | 9,579,000 | 2.48% | ||
| 12 | FEDERATED HERMES, INC. | 361,488 | 8,115,000 | 2.10% | ||
| 13 | Opaleye Management Inc. | 235,000 | 5,276,000 | 1.37% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 231,267 | 5,192,000 | 1.35% | ||
| 15 | Cormorant Asset Management, LP | 200,000 | 4,490,000 | 1.16% | ||
| 16 | GOLDMAN SACHS GROUP INC | 196,206 | 4,405,000 | 1.14% | ||
| 17 | VANGUARD GROUP INC | 183,274 | 4,114,000 | 1.07% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 178,825 | 4,015,000 | 1.04% | ||
| 19 | NORTHERN TRUST CORP | 73,431 | 1,648,000 | 0.43% | ||
| 20 | STATE STREET CORP | 68,872 | 1,545,000 | 0.40% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 63,049 | 1,415,000 | 0.37% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 59,866 | 1,343,000 | 0.35% | ||
| 23 | PRINCIPAL FINANCIAL GROUP INC | 44,847 | 1,007,000 | 0.26% | ||
| 24 | DEUTSCHE BANK AG\ | 41,911 | 940,000 | 0.24% | ||
| 25 | ArrowMark Colorado Holdings LLC | 39,156 | 879,000 | 0.23% | ||
| 26 | Bank of New York Mellon Corp | 32,640 | 733,000 | 0.19% | ||
| 27 | BLACKROCK ADVISORS LLC | 31,915 | 716,000 | 0.19% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 24,454 | 549,000 | 0.14% | ||
| 29 | BlackRock Investment Management, LLC | 20,281 | 455,000 | 0.12% | ||
| 30 | Partner Investment Management, L.P. | 19,664 | 441,000 | 0.11% | ||
| 31 | NORGES BANK | 19,200 | 431,000 | 0.11% | ||
| 32 | ProShare Advisors LLC | 17,513 | 393,000 | 0.10% | ||
| 33 | CREDIT SUISSE AG/ | 17,493 | 392,000 | 0.10% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,992 | 360,000 | 0.09% | ||
| 35 | MORGAN STANLEY | 14,429 | 324,000 | 0.08% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,828 | 288,000 | 0.07% | ||
| 37 | BlackRock Group LTD | 12,059 | 271,000 | 0.07% | ||
| 38 | TD ASSET MANAGEMENT INC | 10,200 | 229,000 | 0.06% | ||
| 39 | SHEPHERD KAPLAN KROCHUK, LLC | 10,100 | 227,000 | 0.06% | ||
| 40 | CITIGROUP INC | 10,066 | 226,000 | 0.06% | ||
| 41 | TEACHERS ADVISORS, LLC | 9,682 | 217,000 | 0.06% | ||
| 42 | Swiss National Bank | 8,200 | 184,000 | 0.05% | ||
| 43 | Nationwide Fund Advisors | 5,321 | 119,000 | 0.03% | ||
| 44 | SG Americas Securities, LLC | 4,478 | 101,000 | 0.03% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 4,358 | 97,837 | 0.03% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,255 | 73,000 | 0.02% | ||
| 47 | STRS OHIO | 2,400 | 54,000 | 0.01% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 1,700 | 38,000 | 0.01% | ||
| 49 | ROYAL BANK OF CANADA | 1,200 | 27,000 | 0.01% | ||
| 50 | BlackRock Japan Co. Ltd | 1,179 | 26,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
