| 1 |
FMR LLC |
4,395,836 |
54,464,000 |
20.82% |
|
|
| 2 |
BAKER BROS. ADVISORS LP |
3,241,783 |
40,166,000 |
15.35% |
|
|
| 3 |
PERCEPTIVE ADVISORS LLC |
2,299,454 |
28,490,000 |
10.89% |
|
|
| 4 |
Aisling Capital LLC |
2,279,568 |
28,244,000 |
10.80% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
2,039,223 |
25,266,000 |
9.66% |
|
|
| 6 |
FEDERATED HERMES, INC. |
1,082,150 |
13,408,000 |
5.13% |
|
|
| 7 |
BlackRock Fund Advisors |
928,697 |
11,507,000 |
4.40% |
|
|
| 8 |
JPMORGAN CHASE & CO |
673,612 |
8,346,000 |
3.19% |
|
|
| 9 |
VANGUARD GROUP INC |
612,400 |
7,588,000 |
2.90% |
|
|
| 10 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
521,244 |
6,458,000 |
2.47% |
|
|
| 11 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
490,503 |
6,077,000 |
2.32% |
|
|
| 12 |
BlackRock Institutional Trust Company, N.A. |
404,381 |
5,010,000 |
1.92% |
|
|
| 13 |
STATE STREET CORP |
319,564 |
3,959,000 |
1.51% |
|
|
| 14 |
NORTHERN TRUST CORP |
241,632 |
2,994,000 |
1.14% |
|
|
| 15 |
PRINCIPAL FINANCIAL GROUP INC |
195,198 |
2,419,000 |
0.92% |
|
|
| 16 |
ArrowMark Colorado Holdings LLC |
150,946 |
1,870,000 |
0.71% |
|
|
| 17 |
Point72 Asset Management, L.P. |
147,800 |
1,831,000 |
0.70% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
130,508 |
1,616,000 |
0.62% |
|
|
| 19 |
Bank of New York Mellon Corp |
87,027 |
1,079,000 |
0.41% |
|
|
| 20 |
BlackRock Investment Management, LLC |
85,066 |
1,054,000 |
0.40% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
73,980 |
917,000 |
0.35% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
55,863 |
693,000 |
0.26% |
|
|
| 23 |
ROYCE & ASSOCIATES LP |
52,592 |
652,000 |
0.25% |
|
|
| 24 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
41,734 |
517,000 |
0.20% |
|
|
| 25 |
ALPS ADVISORS INC |
38,677 |
479,000 |
0.18% |
|
|
| 26 |
Spark Investment Management LLC |
36,500 |
452,000 |
0.17% |
|
|
| 27 |
MILLENNIUM MANAGEMENT LLC |
35,354 |
438,000 |
0.17% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
33,025 |
409,000 |
0.16% |
|
|
| 29 |
RHUMBLINE ADVISERS |
29,667 |
368,000 |
0.14% |
|
|
| 30 |
Swiss National Bank |
27,100 |
336,000 |
0.13% |
|
|
| 31 |
ProShare Advisors LLC |
26,887 |
333,000 |
0.13% |
|
|
| 32 |
COLUMBUS CIRCLE INVESTORS |
24,973 |
309,000 |
0.12% |
|
|
| 33 |
GOLDMAN SACHS GROUP INC |
21,428 |
265,000 |
0.10% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,500 |
254,000 |
0.10% |
|
|
| 35 |
CREDIT SUISSE AG/ |
20,060 |
248,000 |
0.09% |
|
|
| 36 |
AQR CAPITAL MANAGEMENT LLC |
19,430 |
241,000 |
0.09% |
|
|
| 37 |
DIMENSIONAL FUND ADVISORS LP |
18,389 |
228,000 |
0.09% |
|
|
| 38 |
CITIGROUP INC |
17,639 |
219,000 |
0.08% |
|
|
| 39 |
METROPOLITAN LIFE INSURANCE CO/NY |
16,881 |
209,000 |
0.08% |
|
|
| 40 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
15,961 |
198,000 |
0.08% |
|
|
| 41 |
A.R.T. Advisors, LLC |
15,386 |
190,000 |
0.07% |
|
|
| 42 |
DekaBank Deutsche Girozentrale |
14,900 |
186,000 |
0.07% |
|
|
| 43 |
Nationwide Fund Advisors |
14,469 |
179,000 |
0.07% |
|
|
| 44 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,175 |
163,000 |
0.06% |
|
|
| 45 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
12,500 |
155,000 |
0.06% |
|
|
| 46 |
OXFORD ASSET MANAGEMENT LLP |
12,154 |
152,000 |
0.06% |
|
|
| 47 |
VOYA INVESTMENT MANAGEMENT LLC |
11,866 |
147,000 |
0.06% |
|
|
| 48 |
ALLIANCEBERNSTEIN L.P. |
12,300 |
142,000 |
0.05% |
|
|
| 49 |
BLACKROCK ADVISORS LLC |
9,921 |
123,000 |
0.05% |
|
|
| 50 |
PANAGORA ASSET MANAGEMENT INC |
6,661 |
83,000 |
0.03% |
|
|
