| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,629,221 | 68,919,000 | 27.91% | ||
| 2 | Aisling Capital LLC | 1,994,568 | 37,880,000 | 15.34% | ||
| 3 | BAKER BROS. ADVISORS LP | 1,246,089 | 23,663,000 | 9.58% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 898,993 | 17,072,000 | 6.91% | ||
| 5 | HealthCor Management, L.P. | 750,000 | 14,243,000 | 5.77% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 553,769 | 10,516,000 | 4.26% | ||
| 7 | JPMORGAN CHASE & CO | 552,305 | 10,489,000 | 4.25% | ||
| 8 | PFM Health Sciences, LP | 546,238 | 10,373,000 | 4.20% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 487,262 | 9,253,000 | 3.75% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 433,000 | 8,223,000 | 3.33% | ||
| 11 | FEDERATED HERMES, INC. | 361,488 | 6,865,000 | 2.78% | ||
| 12 | Cormorant Asset Management, LP | 200,000 | 3,798,000 | 1.54% | ||
| 13 | GOLDMAN SACHS GROUP INC | 197,215 | 3,745,000 | 1.52% | ||
| 14 | BlackRock Fund Advisors | 163,902 | 3,112,000 | 1.26% | ||
| 15 | VANGUARD GROUP INC | 150,493 | 2,858,000 | 1.16% | ||
| 16 | Rock Springs Capital Management LP | 124,255 | 2,360,000 | 0.96% | ||
| 17 | NORTHERN TRUST CORP | 71,787 | 1,364,000 | 0.55% | ||
| 18 | STATE STREET CORP | 65,382 | 1,245,000 | 0.50% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 58,580 | 1,113,000 | 0.45% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 58,325 | 1,107,000 | 0.45% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 57,104 | 1,084,000 | 0.44% | ||
| 22 | JENNISON ASSOCIATES LLC | 50,135 | 952,000 | 0.39% | ||
| 23 | PRINCIPAL FINANCIAL GROUP INC | 45,693 | 868,000 | 0.35% | ||
| 24 | Bank of New York Mellon Corp | 27,453 | 521,000 | 0.21% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,308 | 500,000 | 0.20% | ||
| 26 | BLACKROCK ADVISORS LLC | 24,133 | 458,000 | 0.19% | ||
| 27 | PDT Partners, LLC | 21,421 | 407,000 | 0.16% | ||
| 28 | BlackRock Investment Management, LLC | 20,338 | 386,000 | 0.16% | ||
| 29 | NORGES BANK | 19,200 | 365,000 | 0.15% | ||
| 30 | MORGAN STANLEY | 18,027 | 343,000 | 0.14% | ||
| 31 | UBS AG | 17,607 | 334,000 | 0.14% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,626 | 297,000 | 0.12% | ||
| 33 | Weiss Multi-Strategy Advisers LLC | 13,000 | 247,000 | 0.10% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,773 | 243,000 | 0.10% | ||
| 35 | Partner Investment Management, L.P. | 12,500 | 237,000 | 0.10% | ||
| 36 | BANQUE PICTET & CIE SA | 12,220 | 232,000 | 0.09% | ||
| 37 | ArrowMark Colorado Holdings LLC | 11,538 | 219,000 | 0.09% | ||
| 38 | TD ASSET MANAGEMENT INC | 10,200 | 194,000 | 0.08% | ||
| 39 | SHEPHERD KAPLAN KROCHUK, LLC | 10,100 | 192,000 | 0.08% | ||
| 40 | TEACHERS ADVISORS, LLC | 9,682 | 184,000 | 0.07% | ||
| 41 | Nationwide Fund Advisors | 5,321 | 101,000 | 0.04% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,238 | 100,000 | 0.04% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 4,530 | 86,025 | 0.03% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 2,600 | 49,000 | 0.02% | ||
| 45 | STRS OHIO | 2,400 | 46,000 | 0.02% | ||
| 46 | ROYAL BANK OF CANADA | 1,200 | 23,000 | 0.01% | ||
| 47 | BlackRock Japan Co. Ltd | 559 | 11,000 | 0.00% | ||
| 48 | CITIGROUP INC | 354 | 7,000 | 0.00% | ||
| 49 | WELLS FARGO & COMPANY/MN | 319 | 6,000 | 0.00% | ||
| 50 | Tower Research Capital LLC (TRC) | 200 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
