| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 4,153,685 | 61,889,000 | 15.53% | ||
| 2 | FMR LLC | 4,128,376 | 61,513,000 | 15.43% | ||
| 3 | Aisling Capital LLC | 2,524,465 | 37,615,000 | 9.44% | ||
| 4 | SOFINNOVA MANAGEMENT VIII, L.L.C. | 2,361,978 | 35,193,000 | 8.83% | ||
| 5 | New Leaf Venture Partners, L.L.C. | 2,039,223 | 30,384,000 | 7.62% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,920,845 | 28,621,000 | 7.18% | ||
| 7 | BlackRock Fund Advisors | 1,508,870 | 22,482,000 | 5.64% | ||
| 8 | FEDERATED HERMES, INC. | 1,472,910 | 21,946,000 | 5.51% | ||
| 9 | VANGUARD GROUP INC | 900,929 | 13,425,000 | 3.37% | ||
| 10 | JPMORGAN CHASE & CO | 858,141 | 12,787,000 | 3.21% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 550,931 | 8,209,000 | 2.06% | ||
| 12 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 511,610 | 7,623,000 | 1.91% | ||
| 13 | STATE STREET CORP | 445,716 | 6,638,000 | 1.67% | ||
| 14 | ArrowMark Colorado Holdings LLC | 376,061 | 5,603,000 | 1.41% | ||
| 15 | NORTHERN TRUST CORP | 367,051 | 5,469,000 | 1.37% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 250,000 | 3,725,000 | 0.93% | ||
| 17 | NF TRINITY CAPITAL (HONG KONG) LTD | 244,897 | 3,649,000 | 0.92% | ||
| 18 | PRINCIPAL FINANCIAL GROUP INC | 190,100 | 2,832,000 | 0.71% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 182,552 | 2,720,000 | 0.68% | ||
| 20 | Bank of New York Mellon Corp | 135,581 | 2,020,000 | 0.51% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 130,377 | 1,943,000 | 0.49% | ||
| 22 | BlackRock Investment Management, LLC | 125,088 | 1,864,000 | 0.47% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,139 | 1,537,000 | 0.39% | ||
| 24 | MORGAN STANLEY | 93,721 | 1,396,000 | 0.35% | ||
| 25 | GOLDMAN SACHS GROUP INC | 90,112 | 1,343,000 | 0.34% | ||
| 26 | TFS CAPITAL LLC | 81,527 | 1,215,000 | 0.30% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,495 | 961,000 | 0.24% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 60,740 | 905,000 | 0.23% | ||
| 29 | TEACHERS ADVISORS, LLC | 50,368 | 750,000 | 0.19% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,350 | 750,000 | 0.19% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 49,400 | 736,000 | 0.18% | ||
| 32 | Swiss National Bank | 44,600 | 665,000 | 0.17% | ||
| 33 | CITIGROUP INC | 43,229 | 644,000 | 0.16% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 36,593 | 545,000 | 0.14% | ||
| 35 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 36,324 | 541,000 | 0.14% | ||
| 36 | ALPS ADVISORS INC | 33,437 | 498,000 | 0.12% | ||
| 37 | RHUMBLINE ADVISERS | 32,346 | 482,000 | 0.12% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 29,600 | 441,000 | 0.11% | ||
| 39 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 29,396 | 438,000 | 0.11% | ||
| 40 | ProShare Advisors LLC | 28,022 | 418,000 | 0.10% | ||
| 41 | A.R.T. Advisors, LLC | 25,700 | 382,000 | 0.10% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 25,513 | 380,000 | 0.10% | ||
| 43 | METROPOLITAN LIFE INSURANCE CO/NY | 23,257 | 347,000 | 0.09% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,344 | 333,000 | 0.08% | ||
| 45 | WELLS FARGO & COMPANY/MN | 21,211 | 316,000 | 0.08% | ||
| 46 | CREDIT SUISSE AG/ | 21,149 | 315,000 | 0.08% | ||
| 47 | DEUTSCHE BANK AG\ | 19,507 | 290,000 | 0.07% | ||
| 48 | Nationwide Fund Advisors | 18,332 | 273,000 | 0.07% | ||
| 49 | STRS OHIO | 17,400 | 259,000 | 0.06% | ||
| 50 | JACOBS LEVY EQUITY MANAGEMENT, INC | 16,800 | 250,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
