| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,271,794 | 78,473,000 | 19.91% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,977,396 | 54,694,000 | 13.88% | ||
| 3 | Aisling Capital LLC | 2,279,568 | 41,876,000 | 10.62% | ||
| 4 | New Leaf Venture Partners, L.L.C. | 2,039,223 | 37,461,000 | 9.50% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 1,546,471 | 24,161,000 | 6.13% | ||
| 6 | FEDERATED HERMES, INC. | 1,178,600 | 21,650,000 | 5.49% | ||
| 7 | HealthCor Management, L.P. | 917,600 | 16,856,000 | 4.28% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 879,200 | 16,151,000 | 4.10% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 713,443 | 13,106,000 | 3.33% | ||
| 10 | BlackRock Fund Advisors | 592,545 | 10,885,000 | 2.76% | ||
| 11 | JPMORGAN CHASE & CO | 591,228 | 10,861,000 | 2.76% | ||
| 12 | PFM Health Sciences, LP | 477,083 | 8,764,000 | 2.22% | ||
| 13 | VANGUARD GROUP INC | 423,635 | 7,782,000 | 1.97% | ||
| 14 | GREAT POINT PARTNERS LLC | 385,000 | 7,072,000 | 1.79% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 339,703 | 6,240,000 | 1.58% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 231,267 | 4,248,000 | 1.08% | ||
| 17 | Tourbillon Capital Partners, L.P. | 200,000 | 3,674,000 | 0.93% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 174,600 | 3,207,000 | 0.81% | ||
| 19 | Cormorant Asset Management, LP | 170,000 | 3,123,000 | 0.79% | ||
| 20 | COLUMBUS CIRCLE INVESTORS | 133,355 | 2,450,000 | 0.62% | ||
| 21 | STATE STREET CORP | 101,367 | 1,862,000 | 0.47% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 97,198 | 1,785,000 | 0.45% | ||
| 23 | CREDIT SUISSE AG/ | 93,830 | 1,723,000 | 0.44% | ||
| 24 | NORTHERN TRUST CORP | 91,418 | 1,679,000 | 0.43% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 88,883 | 1,633,000 | 0.41% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 86,347 | 1,586,000 | 0.40% | ||
| 27 | ArrowMark Colorado Holdings LLC | 81,477 | 1,497,000 | 0.38% | ||
| 28 | Bank of New York Mellon Corp | 57,266 | 1,052,000 | 0.27% | ||
| 29 | DEUTSCHE BANK AG\ | 44,085 | 809,000 | 0.21% | ||
| 30 | SHEPHERD KAPLAN KROCHUK, LLC | 34,364 | 631,000 | 0.16% | ||
| 31 | BLACKROCK ADVISORS LLC | 33,939 | 623,000 | 0.16% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,134 | 517,000 | 0.13% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 27,010 | 496,000 | 0.13% | ||
| 34 | A.R.T. Advisors, LLC | 26,882 | 493,000 | 0.13% | ||
| 35 | ProShare Advisors LLC | 24,647 | 453,000 | 0.11% | ||
| 36 | BlackRock Investment Management, LLC | 24,152 | 444,000 | 0.11% | ||
| 37 | CITADEL ADVISORS LLC | 22,592 | 415,000 | 0.11% | ||
| 38 | TD ASSET MANAGEMENT INC | 22,100 | 406,000 | 0.10% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,428 | 283,000 | 0.07% | ||
| 40 | Swiss National Bank | 14,700 | 270,000 | 0.07% | ||
| 41 | ALPS ADVISORS INC | 14,141 | 260,000 | 0.07% | ||
| 42 | DekaBank Deutsche Girozentrale | 13,400 | 246,000 | 0.06% | ||
| 43 | TEACHERS ADVISORS, LLC | 12,507 | 230,000 | 0.06% | ||
| 44 | BlackRock Group LTD | 12,059 | 222,000 | 0.06% | ||
| 45 | Partner Investment Management, L.P. | 11,888 | 218,000 | 0.06% | ||
| 46 | MORGAN STANLEY | 11,533 | 212,000 | 0.05% | ||
| 47 | GOLDMAN SACHS GROUP INC | 11,298 | 208,000 | 0.05% | ||
| 48 | CITIGROUP INC | 10,430 | 191,000 | 0.05% | ||
| 49 | SECOR Capital Advisors, LP | 10,281 | 189,000 | 0.05% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 6,600 | 121,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
