| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 8,166,247 | 83,622,000 | 17.26% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 6,516,327 | 66,727,000 | 13.77% | ||
| 3 | NEA Management Company, LLC | 6,260,851 | 64,111,000 | 13.23% | ||
| 4 | VANGUARD GROUP INC | 2,826,810 | 28,946,000 | 5.98% | ||
| 5 | Palo Alto Investors LP | 2,711,381 | 27,765,000 | 5.73% | ||
| 6 | JENNISON ASSOCIATES LLC | 1,778,675 | 18,214,000 | 3.76% | ||
| 7 | MPM ASSET MANAGEMENT LLC | 1,729,674 | 17,712,000 | 3.66% | ||
| 8 | BlackRock Fund Advisors | 1,689,314 | 17,299,000 | 3.57% | ||
| 9 | FRANKLIN RESOURCES INC | 1,200,000 | 12,288,000 | 2.54% | ||
| 10 | Foresite Capital Management II, LLC | 1,191,995 | 12,206,000 | 2.52% | ||
| 11 | STATE STREET CORP | 1,003,059 | 10,268,000 | 2.12% | ||
| 12 | QVT Financial LP | 971,946 | 9,953,000 | 2.05% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 935,156 | 9,576,000 | 1.98% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 828,299 | 8,482,000 | 1.75% | ||
| 15 | EcoR1 Capital, LLC | 755,046 | 7,732,000 | 1.60% | ||
| 16 | CQS Cayman LP | 635,000 | 6,502,000 | 1.34% | ||
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 622,299 | 6,372,000 | 1.32% | ||
| 18 | Rock Springs Capital Management LP | 597,500 | 6,118,000 | 1.26% | ||
| 19 | FORESITE CAPITAL MANAGEMENT III, LLC | 511,777 | 5,241,000 | 1.08% | ||
| 20 | NORGES BANK | 492,631 | 5,045,000 | 1.04% | ||
| 21 | NORTHERN TRUST CORP | 458,311 | 4,693,000 | 0.97% | ||
| 22 | Tekla Capital Management LLC | 400,000 | 4,096,000 | 0.85% | ||
| 23 | CASDIN CAPITAL, LLC | 340,000 | 3,482,000 | 0.72% | ||
| 24 | Spark Investment Management LLC | 331,300 | 3,392,000 | 0.70% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 301,224 | 3,084,000 | 0.64% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 275,000 | 2,816,000 | 0.58% | ||
| 27 | MORGAN STANLEY | 270,216 | 2,767,000 | 0.57% | ||
| 28 | BAKER BROS. ADVISORS LP | 232,481 | 2,381,000 | 0.49% | ||
| 29 | JPMORGAN CHASE & CO | 224,156 | 2,295,000 | 0.47% | ||
| 30 | Iguana Healthcare Management, LLC | 200,000 | 2,048,000 | 0.42% | ||
| 31 | Candriam S.C.A. | 184,000 | 1,884,000 | 0.39% | ||
| 32 | Bank of New York Mellon Corp | 169,352 | 1,735,000 | 0.36% | ||
| 33 | Cormorant Asset Management, LP | 159,513 | 1,633,000 | 0.34% | ||
| 34 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 155,400 | 1,591,000 | 0.33% | ||
| 35 | BlackRock Investment Management, LLC | 153,876 | 1,576,000 | 0.33% | ||
| 36 | TFS CAPITAL LLC | 139,448 | 1,428,000 | 0.29% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 133,351 | 1,366,000 | 0.28% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 130,033 | 1,332,000 | 0.27% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 127,302 | 1,304,000 | 0.27% | ||
| 40 | QS Investors, LLC | 94,526 | 968,000 | 0.20% | ||
| 41 | DEUTSCHE BANK AG\ | 93,576 | 957,000 | 0.20% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,441 | 865,000 | 0.18% | ||
| 43 | PRINCIPAL FINANCIAL GROUP INC | 81,178 | 831,000 | 0.17% | ||
| 44 | ALPS ADVISORS INC | 80,387 | 823,000 | 0.17% | ||
| 45 | TEACHERS ADVISORS, LLC | 67,829 | 695,000 | 0.14% | ||
| 46 | SECOR Capital Advisors, LP | 60,556 | 620,000 | 0.13% | ||
| 47 | Swiss National Bank | 56,500 | 579,000 | 0.12% | ||
| 48 | CREDIT SUISSE AG/ | 54,530 | 558,000 | 0.12% | ||
| 49 | AMERICAN CENTURY COMPANIES INC | 50,604 | 518,000 | 0.11% | ||
| 50 | ProShare Advisors LLC | 47,522 | 487,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
