| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 13,770,982 | 433,648,000 | 45.30% | ||
| 2 | Camber Capital Management LP | 2,458,100 | 77,406,000 | 8.09% | ||
| 3 | BlackRock Finance, Inc. | 2,386,792 | 75,160,000 | 7.85% | ||
| 4 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,607,649 | 50,625,000 | 5.29% | ||
| 5 | VANGUARD GROUP INC | 1,564,170 | 49,256,000 | 5.15% | ||
| 6 | RENAISSANCE TECHNOLOGIES LLC | 733,200 | 23,088,000 | 2.41% | ||
| 7 | LOOMIS SAYLES & CO L P | 584,515 | 18,406,000 | 1.92% | ||
| 8 | STATE STREET CORP | 504,617 | 15,887,000 | 1.66% | ||
| 9 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 482,675 | 15,200,000 | 1.59% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 470,353 | 14,811,000 | 1.55% | ||
| 11 | EAGLE ASSET MANAGEMENT INC | 320,553 | 10,094,000 | 1.05% | ||
| 12 | STATE FARM MUTUAL AUTOMOBILE INSURANCE CO | 317,240 | 9,990,000 | 1.04% | ||
| 13 | Tributary Capital Management, LLC | 294,962 | 9,288,000 | 0.97% | ||
| 14 | GOLDMAN SACHS GROUP INC | 294,048 | 9,259,000 | 0.97% | ||
| 15 | NORTHERN TRUST CORP | 248,152 | 7,814,000 | 0.82% | ||
| 16 | FMR LLC | 246,348 | 7,757,000 | 0.81% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 205,838 | 6,480,000 | 0.68% | ||
| 18 | PRUDENTIAL FINANCIAL INC | 195,740 | 6,164,000 | 0.64% | ||
| 19 | Spark Investment Management LLC | 189,700 | 5,973,000 | 0.62% | ||
| 20 | LORD, ABBETT & CO. LLC | 182,623 | 5,751,000 | 0.60% | ||
| 21 | TWO SIGMA INVESTMENTS, LP | 179,600 | 5,656,000 | 0.59% | ||
| 22 | NORGES BANK | 154,668 | 4,870,000 | 0.51% | ||
| 23 | AJO, LP | 150,359 | 4,735,000 | 0.49% | ||
| 24 | Motley Fool Asset Management LLC | 131,935 | 4,155,000 | 0.43% | ||
| 25 | Mitsubishi UFJ Trust & Banking Corp | 128,200 | 4,037,000 | 0.42% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 126,202 | 3,974,000 | 0.42% | ||
| 27 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 118,500 | 3,732,000 | 0.39% | ||
| 28 | TWO SIGMA ADVISERS, LP | 115,974 | 3,652,000 | 0.38% | ||
| 29 | JACOBS LEVY EQUITY MANAGEMENT, INC | 105,430 | 3,320,000 | 0.35% | ||
| 30 | OPPENHEIMER & CO INC | 98,749 | 3,109,000 | 0.32% | ||
| 31 | Candriam S.C.A. | 95,000 | 2,992,000 | 0.31% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 92,105 | 2,900,000 | 0.30% | ||
| 33 | Bank of New York Mellon Corp | 88,577 | 2,789,000 | 0.29% | ||
| 34 | UNIVERSITY OF NOTRE DAME DU LAC | 79,693 | 2,510,000 | 0.26% | ||
| 35 | EMORY UNIVERSITY | 76,851 | 2,420,000 | 0.25% | ||
| 36 | PANAGORA ASSET MANAGEMENT INC | 73,399 | 2,311,000 | 0.24% | ||
| 37 | MORGAN STANLEY | 71,738 | 2,258,000 | 0.24% | ||
| 38 | D. E. Shaw & Co., Inc. | 71,578 | 2,254,000 | 0.24% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 71,233 | 2,243,000 | 0.23% | ||
| 40 | FIRST MANHATTAN CO. LLC. | 70,000 | 2,204,000 | 0.23% | ||
| 41 | CREDIT SUISSE AG/ | 62,764 | 1,977,000 | 0.21% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 60,200 | 1,896,000 | 0.20% | ||
| 43 | Numeric Investors LLC | 58,576 | 1,845,000 | 0.19% | ||
| 44 | BANK OF MONTREAL /CAN/ | 55,177 | 1,738,000 | 0.18% | ||
| 45 | NORDEA INVESTMENT MANAGEMENT AB | 53,607 | 1,688,000 | 0.18% | ||
| 46 | WELLS FARGO & COMPANY/MN | 51,684 | 1,628,000 | 0.17% | ||
| 47 | AMERIPRISE FINANCIAL INC | 50,914 | 1,603,000 | 0.17% | ||
| 48 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 48,379 | 1,523,000 | 0.16% | ||
| 49 | CITADEL ADVISORS LLC | 43,442 | 1,368,000 | 0.14% | ||
| 50 | Convergence Investment Partners, LLC | 39,735 | 1,251,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
