| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 21,006,208 | 1,185,590,000 | 12.67% | ||
| 2 | Capital World Investors | 17,663,200 | 996,911,000 | 10.65% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 16,231,351 | 916,098,000 | 9.79% | ||
| 4 | BAKER BROS. ADVISORS LP | 14,845,559 | 837,883,000 | 8.95% | ||
| 5 | VANGUARD GROUP INC | 8,405,140 | 474,386,000 | 5.07% | ||
| 6 | JENNISON ASSOCIATES LLC | 7,116,713 | 401,667,000 | 4.29% | ||
| 7 | BB BIOTECH AG | 4,163,790 | 235,004,000 | 2.51% | ||
| 8 | Artisan Partners Limited Partnership | 4,120,108 | 232,539,000 | 2.49% | ||
| 9 | FRANKLIN RESOURCES INC | 3,855,065 | 217,578,000 | 2.33% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,608,081 | 203,640,000 | 2.18% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 3,606,652 | 203,559,000 | 2.18% | ||
| 12 | ORBIMED ADVISORS LLC | 3,500,400 | 197,563,000 | 2.11% | ||
| 13 | Ignis Investment Services Ltd | 353,152 | 196,070,000 | 2.10% | ||
| 14 | CANADA PENSION PLAN INVESTMENT BOARD | 3,400,100 | 191,902,000 | 2.05% | ||
| 15 | BlackRock Fund Advisors | 3,084,396 | 174,083,000 | 1.86% | ||
| 16 | FMR LLC | 3,075,836 | 173,600,000 | 1.86% | ||
| 17 | STATE STREET CORP | 2,353,025 | 132,809,000 | 1.42% | ||
| 18 | JANUS HENDERSON INVESTORS US LLC | 2,063,928 | 116,479,000 | 1.24% | ||
| 19 | FIRST TRUST ADVISORS LP | 1,926,990 | 108,759,000 | 1.16% | ||
| 20 | GILDER GAGNON HOWE & CO LLC | 1,585,534 | 89,488,000 | 0.96% | ||
| 21 | SECTORAL ASSET MANAGEMENT INC | 1,571,452 | 88,693,000 | 0.95% | ||
| 22 | Invesco Ltd. | 1,508,968 | 85,166,000 | 0.91% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,403,409 | 79,208,000 | 0.85% | ||
| 24 | NORGES BANK | 1,328,084 | 74,957,000 | 0.80% | ||
| 25 | LORD, ABBETT & CO. LLC | 1,177,705 | 66,446,000 | 0.71% | ||
| 26 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,084,600 | 61,215,000 | 0.65% | ||
| 27 | FRONTIER CAPITAL MANAGEMENT CO LLC | 963,931 | 54,404,000 | 0.58% | ||
| 28 | WADDELL & REED FINANCIAL INC | 933,844 | 52,706,000 | 0.56% | ||
| 29 | TWO SIGMA ADVISERS, LP | 932,763 | 52,645,000 | 0.56% | ||
| 30 | GOLDMAN SACHS GROUP INC | 927,572 | 52,353,000 | 0.56% | ||
| 31 | DEUTSCHE BANK AG\ | 837,739 | 47,278,000 | 0.51% | ||
| 32 | AMERICAN CENTURY COMPANIES INC | 790,253 | 44,602,000 | 0.48% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 768,470 | 43,372,000 | 0.46% | ||
| 34 | Tekla Capital Management LLC | 768,238 | 43,359,000 | 0.46% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 730,152 | 41,210,000 | 0.44% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 711,931 | 40,181,000 | 0.43% | ||
| 37 | FEDERATED HERMES, INC. | 706,100 | 39,852,000 | 0.43% | ||
| 38 | NORTHERN TRUST CORP | 639,277 | 36,081,000 | 0.39% | ||
| 39 | OppenheimerFunds, Inc. | 621,120 | 35,056,000 | 0.37% | ||
| 40 | Bank of New York Mellon Corp | 611,530 | 34,514,000 | 0.37% | ||
| 41 | AMERIPRISE FINANCIAL INC | 566,815 | 31,989,000 | 0.34% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 550,409 | 31,065,000 | 0.33% | ||
| 43 | CITADEL ADVISORS LLC | 530,251 | 29,927,000 | 0.32% | ||
| 44 | RAINIER INVESTMENT MANAGEMENT LLC | 529,240 | 29,871,000 | 0.32% | ||
| 45 | ROCKEFELLER FINANCIAL SERVICES INC | 518,889 | 29,286,000 | 0.31% | ||
| 46 | COLUMBUS CIRCLE INVESTORS | 465,416 | 26,268,000 | 0.28% | ||
| 47 | MORGAN STANLEY | 442,758 | 24,990,000 | 0.27% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 430,200 | 24,280,000 | 0.26% | Call | |
| 49 | Legal & General Group Plc | 428,760 | 24,199,000 | 0.26% | ||
| 50 | CHARTWELL INVESTMENT PARTNERS, LLC | 402,772 | 22,732,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
