| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 19,475,316 | 2,112,098,000 | 11.05% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 19,059,471 | 2,067,000,000 | 10.82% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 13,097,566 | 1,420,431,000 | 7.43% | ||
| 4 | VANGUARD GROUP INC | 11,685,539 | 1,267,298,000 | 6.63% | ||
| 5 | Capital World Investors | 11,275,383 | 1,222,815,000 | 6.40% | ||
| 6 | FMR LLC | 6,343,428 | 687,945,000 | 3.60% | ||
| 7 | Capital International Investors | 5,394,586 | 585,043,000 | 3.06% | ||
| 8 | SANDS CAPITAL MANAGEMENT, LLC | 4,420,966 | 479,454,000 | 2.51% | ||
| 9 | JPMORGAN CHASE & CO | 3,951,038 | 428,490,000 | 2.24% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,928,078 | 426,000,000 | 2.23% | ||
| 11 | BlackRock Fund Advisors | 3,769,442 | 408,796,000 | 2.14% | ||
| 12 | BB BIOTECH AG | 3,750,406 | 406,732,000 | 2.13% | ||
| 13 | Invesco Ltd. | 3,290,123 | 356,815,000 | 1.87% | ||
| 14 | STATE STREET CORP | 3,083,383 | 334,397,000 | 1.75% | ||
| 15 | ORBIMED ADVISORS LLC | 2,832,978 | 307,236,000 | 1.61% | ||
| 16 | FRANKLIN RESOURCES INC | 2,616,370 | 283,753,000 | 1.49% | ||
| 17 | CAPITAL GUARDIAN TRUST CO | 2,107,485 | 228,557,000 | 1.20% | ||
| 18 | BROWN CAPITAL MANAGEMENT LLC | 2,098,997 | 227,636,000 | 1.19% | ||
| 19 | JENNISON ASSOCIATES LLC | 2,035,173 | 220,715,000 | 1.16% | ||
| 20 | FIRST TRUST ADVISORS LP | 1,704,822 | 184,888,000 | 0.97% | ||
| 21 | AMERIPRISE FINANCIAL INC | 1,675,831 | 181,744,000 | 0.95% | ||
| 22 | NORGES BANK | 1,467,181 | 159,115,000 | 0.83% | ||
| 23 | WELLS FARGO & COMPANY/MN | 1,391,749 | 150,935,000 | 0.79% | ||
| 24 | AMERICAN CENTURY COMPANIES INC | 1,228,445 | 133,225,000 | 0.70% | ||
| 25 | BlackRock Group LTD | 1,201,393 | 130,291,000 | 0.68% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,198,804 | 130,011,000 | 0.68% | ||
| 27 | DEUTSCHE BANK AG\ | 1,181,321 | 128,109,000 | 0.67% | ||
| 28 | CANADA PENSION PLAN INVESTMENT BOARD | 1,136,521 | 123,256,000 | 0.65% | ||
| 29 | SECTORAL ASSET MANAGEMENT INC | 1,127,423 | 122,269,000 | 0.64% | ||
| 30 | Artisan Partners Limited Partnership | 1,054,935 | 114,408,000 | 0.60% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 1,019,738 | 110,520,000 | 0.58% | ||
| 32 | JANUS HENDERSON INVESTORS US LLC | 1,010,115 | 109,547,000 | 0.57% | ||
| 33 | GILDER GAGNON HOWE & CO LLC | 962,778 | 104,413,000 | 0.55% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 925,679 | 100,390,000 | 0.53% | ||
| 35 | BLACKROCK ADVISORS LLC | 922,670 | 100,064,000 | 0.52% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 880,626 | 95,504,000 | 0.50% | ||
| 37 | Tekla Capital Management LLC | 880,461 | 95,486,000 | 0.50% | ||
| 38 | TWO SIGMA ADVISERS, LP | 852,414 | 92,444,000 | 0.48% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 819,491 | 88,874,000 | 0.47% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 788,804 | 85,546,000 | 0.45% | ||
| 41 | NORTHERN TRUST CORP | 783,139 | 84,932,000 | 0.44% | ||
| 42 | GOLDMAN SACHS GROUP INC | 782,420 | 84,853,000 | 0.44% | ||
| 43 | Bank of New York Mellon Corp | 710,219 | 77,023,000 | 0.40% | ||
| 44 | FEDERATED HERMES, INC. | 695,552 | 75,433,000 | 0.39% | ||
| 45 | OppenheimerFunds, Inc. | 651,361 | 70,640,000 | 0.37% | ||
| 46 | Legal & General Group Plc | 608,587 | 66,001,000 | 0.35% | ||
| 47 | Artal Group S.A. | 570,000 | 61,817,000 | 0.32% | ||
| 48 | GOLDMAN SACHS GROUP INC | 562,300 | 60,981,000 | 0.32% | Call | |
| 49 | CAPITAL INTERNATIONAL LTD /CA/ | 517,900 | 56,166,000 | 0.29% | ||
| 50 | TWO SIGMA INVESTMENTS, LP | 490,651 | 53,211,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
