| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 20,749,529 | 2,162,308,000 | 12.32% | ||
| 2 | BAKER BROS. ADVISORS LP | 14,865,559 | 1,549,140,000 | 8.82% | ||
| 3 | Capital World Investors | 14,725,100 | 1,534,503,000 | 8.74% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 13,934,432 | 1,452,108,000 | 8.27% | ||
| 5 | VANGUARD GROUP INC | 10,779,267 | 1,123,308,000 | 6.40% | ||
| 6 | Capital International Investors | 5,384,659 | 561,135,000 | 3.20% | ||
| 7 | JENNISON ASSOCIATES LLC | 4,738,303 | 493,779,000 | 2.81% | ||
| 8 | FMR LLC | 4,511,627 | 470,157,000 | 2.68% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,806,374 | 396,662,000 | 2.26% | ||
| 10 | BlackRock Fund Advisors | 3,787,623 | 394,708,000 | 2.25% | ||
| 11 | BB BIOTECH AG | 3,740,406 | 389,788,000 | 2.22% | ||
| 12 | STATE STREET CORP | 2,778,985 | 289,652,000 | 1.65% | ||
| 13 | FRANKLIN RESOURCES INC | 2,739,179 | 285,450,000 | 1.63% | ||
| 14 | BROWN CAPITAL MANAGEMENT LLC | 2,665,207 | 277,741,000 | 1.58% | ||
| 15 | Artisan Partners Limited Partnership | 2,626,821 | 273,741,000 | 1.56% | ||
| 16 | ORBIMED ADVISORS LLC | 2,314,500 | 241,194,000 | 1.37% | ||
| 17 | CAPITAL GUARDIAN TRUST CO | 2,268,523 | 236,403,000 | 1.35% | ||
| 18 | FIRST TRUST ADVISORS LP | 2,212,105 | 230,523,000 | 1.31% | ||
| 19 | Invesco Ltd. | 1,893,166 | 197,287,000 | 1.12% | ||
| 20 | JPMORGAN CHASE & CO | 1,740,091 | 181,334,000 | 1.03% | ||
| 21 | AMERIPRISE FINANCIAL INC | 1,660,017 | 172,988,000 | 0.99% | ||
| 22 | JANUS HENDERSON INVESTORS US LLC | 1,576,210 | 164,257,000 | 0.94% | ||
| 23 | NORGES BANK | 1,391,708 | 145,030,000 | 0.83% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,260,562 | 131,364,000 | 0.75% | ||
| 25 | GILDER GAGNON HOWE & CO LLC | 1,125,048 | 117,241,000 | 0.67% | ||
| 26 | WADDELL & REED FINANCIAL INC | 1,061,085 | 110,576,000 | 0.63% | ||
| 27 | CITADEL ADVISORS LLC | 1,018,680 | 106,157,000 | 0.60% | ||
| 28 | DEUTSCHE BANK AG\ | 970,947 | 101,177,000 | 0.58% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 953,314 | 99,286,000 | 0.57% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 921,528 | 96,032,000 | 0.55% | ||
| 31 | BlackRock Group LTD | 911,146 | 94,950,000 | 0.54% | ||
| 32 | SECTORAL ASSET MANAGEMENT INC | 910,114 | 94,843,000 | 0.54% | ||
| 33 | NORTHERN TRUST CORP | 889,638 | 92,709,000 | 0.53% | ||
| 34 | WELLS FARGO & COMPANY/MN | 882,742 | 91,991,000 | 0.52% | ||
| 35 | Tekla Capital Management LLC | 880,461 | 91,753,000 | 0.52% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 871,801 | 90,850,000 | 0.52% | ||
| 37 | FRONTIER CAPITAL MANAGEMENT CO LLC | 835,693 | 87,088,000 | 0.50% | ||
| 38 | CANADA PENSION PLAN INVESTMENT BOARD | 749,886 | 78,146,000 | 0.45% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 727,059 | 75,767,000 | 0.43% | ||
| 40 | GOLDMAN SACHS GROUP INC | 726,273 | 75,685,000 | 0.43% | ||
| 41 | FEDERATED HERMES, INC. | 723,270 | 75,372,000 | 0.43% | ||
| 42 | BLACKROCK ADVISORS LLC | 676,634 | 70,512,000 | 0.40% | ||
| 43 | Bank of New York Mellon Corp | 658,656 | 68,637,000 | 0.39% | ||
| 44 | TWO SIGMA ADVISERS, LP | 634,625 | 66,134,000 | 0.38% | ||
| 45 | AMERICAN CENTURY COMPANIES INC | 625,545 | 65,188,000 | 0.37% | ||
| 46 | CREDIT SUISSE AG/ | 610,116 | 63,579,000 | 0.36% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 604,070 | 62,950,000 | 0.36% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 562,490 | 58,618,000 | 0.33% | ||
| 49 | Legal & General Group Plc | 537,357 | 55,998,000 | 0.32% | ||
| 50 | CAPITAL INTERNATIONAL LTD /CA/ | 526,000 | 54,814,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
