| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 24,902,072 | 2,348,015,000 | 14.12% | ||
| 2 | BAKER BROS. ADVISORS LP | 23,498,898 | 2,215,711,000 | 13.32% | ||
| 3 | VANGUARD GROUP INC | 12,199,035 | 1,150,247,000 | 6.92% | ||
| 4 | Capital World Investors | 10,686,491 | 1,007,629,000 | 6.06% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,683,961 | 1,007,391,000 | 6.06% | ||
| 6 | Capital International Investors | 5,873,189 | 553,783,000 | 3.33% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 4,269,170 | 402,540,000 | 2.42% | ||
| 8 | BlackRock Fund Advisors | 4,207,817 | 396,755,000 | 2.39% | ||
| 9 | SANDS CAPITAL MANAGEMENT, LLC | 4,124,074 | 388,859,000 | 2.34% | ||
| 10 | FMR LLC | 4,059,441 | 382,765,000 | 2.30% | ||
| 11 | BB BIOTECH AG | 3,879,822 | 365,828,000 | 2.20% | ||
| 12 | STATE STREET CORP | 3,783,687 | 356,761,000 | 2.14% | ||
| 13 | FRANKLIN RESOURCES INC | 2,802,422 | 264,217,000 | 1.59% | ||
| 14 | BROWN CAPITAL MANAGEMENT LLC | 2,647,505 | 249,633,000 | 1.50% | ||
| 15 | Invesco Ltd. | 2,161,983 | 203,854,000 | 1.23% | ||
| 16 | CAPITAL GUARDIAN TRUST CO | 1,936,960 | 182,636,000 | 1.10% | ||
| 17 | ORBIMED ADVISORS LLC | 1,850,178 | 174,453,000 | 1.05% | ||
| 18 | NORGES BANK | 1,518,514 | 136,753,000 | 0.82% | ||
| 19 | Matrix Capital Management Company, LP | 1,400,000 | 132,006,000 | 0.79% | ||
| 20 | AMERIPRISE FINANCIAL INC | 1,336,458 | 126,014,000 | 0.76% | ||
| 21 | DEUTSCHE BANK AG\ | 1,316,525 | 124,130,000 | 0.75% | ||
| 22 | AMERICAN CENTURY COMPANIES INC | 1,262,158 | 119,009,000 | 0.72% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 1,143,444 | 107,772,000 | 0.65% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,121,848 | 105,779,000 | 0.64% | ||
| 25 | BlackRock Group LTD | 1,091,883 | 102,954,000 | 0.62% | ||
| 26 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,014,518 | 95,659,000 | 0.58% | ||
| 27 | GOLDMAN SACHS GROUP INC | 935,414 | 88,199,000 | 0.53% | ||
| 28 | JENNISON ASSOCIATES LLC | 932,316 | 87,908,000 | 0.53% | ||
| 29 | NORTHERN TRUST CORP | 926,249 | 87,336,000 | 0.53% | ||
| 30 | CANADA PENSION PLAN INVESTMENT BOARD | 880,490 | 83,021,000 | 0.50% | ||
| 31 | Tekla Capital Management LLC | 880,461 | 83,019,000 | 0.50% | ||
| 32 | WELLS FARGO & COMPANY/MN | 795,759 | 75,033,000 | 0.45% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 763,100 | 71,953,000 | 0.43% | ||
| 34 | MARSHALL WACE, LLP | 744,174 | 70,168,000 | 0.42% | ||
| 35 | PICTET ASSET MANAGEMENT LTD | 736,745 | 69,468,000 | 0.42% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 730,102 | 68,841,000 | 0.41% | ||
| 37 | JPMORGAN CHASE & CO | 714,917 | 67,486,000 | 0.41% | ||
| 38 | Bank of New York Mellon Corp | 683,062 | 64,405,000 | 0.39% | ||
| 39 | Legal & General Group Plc | 668,056 | 62,991,000 | 0.38% | ||
| 40 | BALYASNY ASSET MANAGEMENT L.P. | 648,390 | 61,137,000 | 0.37% | ||
| 41 | GILDER GAGNON HOWE & CO LLC | 625,503 | 58,979,000 | 0.35% | ||
| 42 | JANUS HENDERSON INVESTORS US LLC | 625,113 | 58,942,000 | 0.35% | ||
| 43 | TWO SIGMA ADVISERS, LP | 619,963 | 58,456,000 | 0.35% | ||
| 44 | HealthCor Management, L.P. | 600,000 | 56,574,000 | 0.34% | ||
| 45 | Artal Group S.A. | 600,000 | 56,574,000 | 0.34% | ||
| 46 | Redmile Group, LLC | 597,638 | 56,351,000 | 0.34% | ||
| 47 | CITADEL ADVISORS LLC | 569,881 | 53,734,000 | 0.32% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 545,682 | 51,452,000 | 0.31% | ||
| 49 | CREDIT SUISSE AG/ | 539,824 | 50,900,000 | 0.31% | ||
| 50 | FRED ALGER MANAGEMENT, LLC | 537,224 | 50,655,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
