| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 20,152,359 | 1,473,339,000 | 12.03% | ||
| 2 | Capital World Investors | 16,510,700 | 1,316,068,000 | 10.75% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 16,995,843 | 1,242,566,000 | 10.15% | ||
| 4 | BAKER BROS. ADVISORS LP | 14,845,559 | 1,085,359,000 | 8.86% | ||
| 5 | VANGUARD GROUP INC | 9,223,856 | 674,356,000 | 5.51% | ||
| 6 | JENNISON ASSOCIATES LLC | 7,183,152 | 525,160,000 | 4.29% | ||
| 7 | BB BIOTECH AG | 4,051,867 | 296,232,000 | 2.42% | ||
| 8 | Artisan Partners Limited Partnership | 3,823,102 | 279,507,000 | 2.28% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,733,718 | 272,972,000 | 2.23% | ||
| 10 | Capital International Investors | 3,625,800 | 265,082,000 | 2.16% | ||
| 11 | BROWN CAPITAL MANAGEMENT LLC | 3,477,556 | 254,244,000 | 2.08% | ||
| 12 | FMR LLC | 3,191,244 | 233,312,000 | 1.91% | ||
| 13 | BlackRock Fund Advisors | 3,183,103 | 232,717,000 | 1.90% | ||
| 14 | ORBIMED ADVISORS LLC | 3,149,300 | 230,245,000 | 1.88% | ||
| 15 | CAPITAL GUARDIAN TRUST CO | 2,856,107 | 227,660,000 | 1.86% | ||
| 16 | STATE STREET CORP | 2,746,789 | 200,813,000 | 1.64% | ||
| 17 | FRANKLIN RESOURCES INC | 2,584,253 | 188,935,000 | 1.54% | ||
| 18 | Invesco Ltd. | 1,886,305 | 137,908,000 | 1.13% | ||
| 19 | GILDER GAGNON HOWE & CO LLC | 1,538,765 | 112,499,000 | 0.92% | ||
| 20 | CANADA PENSION PLAN INVESTMENT BOARD | 1,383,300 | 101,133,000 | 0.83% | ||
| 21 | SECTORAL ASSET MANAGEMENT INC | 1,332,814 | 97,442,000 | 0.80% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,303,929 | 95,330,000 | 0.78% | ||
| 23 | FIRST TRUST ADVISORS LP | 1,241,508 | 90,767,000 | 0.74% | ||
| 24 | NORGES BANK | 1,234,320 | 90,241,000 | 0.74% | ||
| 25 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,234,238 | 90,235,000 | 0.74% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 1,186,134 | 86,718,000 | 0.71% | ||
| 27 | JANUS HENDERSON INVESTORS US LLC | 1,112,497 | 81,335,000 | 0.66% | ||
| 28 | DEUTSCHE BANK AG\ | 1,086,170 | 79,406,000 | 0.65% | ||
| 29 | WADDELL & REED FINANCIAL INC | 1,067,096 | 78,016,000 | 0.64% | ||
| 30 | Tekla Capital Management LLC | 936,461 | 68,465,000 | 0.56% | ||
| 31 | NORTHERN TRUST CORP | 933,174 | 68,223,000 | 0.56% | ||
| 32 | BlackRock Group LTD | 907,676 | 66,361,000 | 0.54% | ||
| 33 | AMERIPRISE FINANCIAL INC | 839,977 | 61,412,000 | 0.50% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 810,850 | 59,249,000 | 0.48% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 704,261 | 51,489,000 | 0.42% | ||
| 36 | BLACKROCK ADVISORS LLC | 693,570 | 50,707,000 | 0.41% | ||
| 37 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 664,790 | 48,603,000 | 0.40% | ||
| 38 | FEDERATED HERMES, INC. | 663,600 | 48,516,000 | 0.40% | ||
| 39 | TWO SIGMA ADVISERS, LP | 656,963 | 48,031,000 | 0.39% | ||
| 40 | Bank of New York Mellon Corp | 635,905 | 46,491,000 | 0.38% | ||
| 41 | Allianz Asset Management GmbH | 621,064 | 45,406,000 | 0.37% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 618,869 | 45,246,000 | 0.37% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 573,254 | 41,910,000 | 0.34% | ||
| 44 | CAPITAL INTERNATIONAL LTD /CA/ | 546,400 | 39,947,000 | 0.33% | ||
| 45 | ROCKEFELLER FINANCIAL SERVICES INC | 540,489 | 39,515,000 | 0.32% | ||
| 46 | CREDIT SUISSE AG/ | 529,452 | 38,708,000 | 0.32% | ||
| 47 | TWO SIGMA INVESTMENTS, LP | 505,638 | 36,967,000 | 0.30% | ||
| 48 | Legal & General Group Plc | 494,555 | 36,157,000 | 0.30% | ||
| 49 | Capital International Sarl | 430,947 | 31,507,000 | 0.26% | ||
| 50 | AXA S.A. | 414,610 | 30,312,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
