| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 21,038,894 | 1,031,958,000 | 13.04% | ||
| 2 | Capital World Investors | 17,663,200 | 866,380,000 | 10.94% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 17,310,804 | 849,094,000 | 10.73% | ||
| 4 | BAKER BROS. ADVISORS LP | 14,845,559 | 728,175,000 | 9.20% | ||
| 5 | VANGUARD GROUP INC | 8,687,985 | 426,145,000 | 5.38% | ||
| 6 | JENNISON ASSOCIATES LLC | 7,380,012 | 361,990,000 | 4.57% | ||
| 7 | BB BIOTECH AG | 4,301,867 | 211,007,000 | 2.67% | ||
| 8 | Artisan Partners Limited Partnership | 4,010,287 | 196,705,000 | 2.48% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,633,584 | 178,227,000 | 2.25% | ||
| 10 | BROWN CAPITAL MANAGEMENT LLC | 3,625,204 | 177,816,000 | 2.25% | ||
| 11 | CANADA PENSION PLAN INVESTMENT BOARD | 3,358,200 | 164,720,000 | 2.08% | ||
| 12 | ORBIMED ADVISORS LLC | 3,254,900 | 159,653,000 | 2.02% | ||
| 13 | BlackRock Fund Advisors | 3,201,252 | 157,021,000 | 1.98% | ||
| 14 | FMR LLC | 3,066,810 | 150,426,000 | 1.90% | ||
| 15 | FRANKLIN RESOURCES INC | 2,953,115 | 144,849,000 | 1.83% | ||
| 16 | STATE STREET CORP | 2,093,551 | 102,692,000 | 1.30% | ||
| 17 | FIRST TRUST ADVISORS LP | 1,986,526 | 97,439,000 | 1.23% | ||
| 18 | Invesco Ltd. | 1,673,893 | 82,105,000 | 1.04% | ||
| 19 | JANUS HENDERSON INVESTORS US LLC | 1,634,232 | 80,159,000 | 1.01% | ||
| 20 | SECTORAL ASSET MANAGEMENT INC | 1,631,812 | 80,040,000 | 1.01% | ||
| 21 | GILDER GAGNON HOWE & CO LLC | 1,578,263 | 77,414,000 | 0.98% | ||
| 22 | NORGES BANK | 1,328,084 | 65,143,000 | 0.82% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,217,578 | 59,722,000 | 0.75% | ||
| 24 | WADDELL & REED FINANCIAL INC | 1,180,848 | 57,921,000 | 0.73% | ||
| 25 | Tekla Capital Management LLC | 1,141,961 | 56,013,000 | 0.71% | ||
| 26 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,000 | 53,955,000 | 0.68% | ||
| 27 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,096,354 | 53,776,000 | 0.68% | ||
| 28 | AMERICAN CENTURY COMPANIES INC | 1,078,323 | 52,892,000 | 0.67% | ||
| 29 | DEUTSCHE BANK AG\ | 1,023,631 | 50,207,000 | 0.63% | ||
| 30 | GOLDMAN SACHS GROUP INC | 910,394 | 44,655,000 | 0.56% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 776,824 | 38,102,000 | 0.48% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 749,152 | 36,746,000 | 0.46% | ||
| 33 | FEDERATED HERMES, INC. | 726,100 | 35,615,000 | 0.45% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 689,334 | 33,812,000 | 0.43% | ||
| 35 | AMERIPRISE FINANCIAL INC | 633,423 | 31,069,000 | 0.39% | ||
| 36 | OppenheimerFunds, Inc. | 632,040 | 31,002,000 | 0.39% | ||
| 37 | NORTHERN TRUST CORP | 615,608 | 30,196,000 | 0.38% | ||
| 38 | Bank of New York Mellon Corp | 590,341 | 28,956,000 | 0.37% | ||
| 39 | TWO SIGMA ADVISERS, LP | 558,563 | 27,398,000 | 0.35% | ||
| 40 | BLACKROCK ADVISORS LLC | 506,506 | 24,844,000 | 0.31% | ||
| 41 | RAINIER INVESTMENT MANAGEMENT LLC | 461,280 | 22,626,000 | 0.29% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 445,199 | 21,837,000 | 0.28% | ||
| 43 | Artal Group S.A. | 440,000 | 21,582,000 | 0.27% | ||
| 44 | AXA S.A. | 436,098 | 21,391,000 | 0.27% | ||
| 45 | Legal & General Group Plc | 433,946 | 21,285,000 | 0.27% | ||
| 46 | Allianz Asset Management GmbH | 427,440 | 20,966,000 | 0.26% | ||
| 47 | BlackRock Group LTD | 404,334 | 19,833,000 | 0.25% | ||
| 48 | CHARTWELL INVESTMENT PARTNERS, LLC | 394,967 | 19,373,000 | 0.24% | ||
| 49 | CREDIT SUISSE AG/ | 387,017 | 18,983,000 | 0.24% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 377,600 | 18,521,000 | 0.23% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
