| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 23,499,087 | 2,356,253,000 | 13.41% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 18,060,127 | 1,810,889,000 | 10.31% | ||
| 3 | VANGUARD GROUP INC | 12,567,950 | 1,260,188,000 | 7.17% | ||
| 4 | Capital World Investors | 10,301,491 | 1,032,931,000 | 5.88% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,030,994 | 704,998,000 | 4.01% | ||
| 6 | Capital International Investors | 6,021,520 | 603,778,000 | 3.44% | ||
| 7 | BlackRock Fund Advisors | 4,436,973 | 444,895,000 | 2.53% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 4,435,321 | 444,730,000 | 2.53% | ||
| 9 | BB BIOTECH AG | 3,879,822 | 389,030,000 | 2.21% | ||
| 10 | SANDS CAPITAL MANAGEMENT, LLC | 3,652,652 | 366,251,000 | 2.08% | ||
| 11 | STATE STREET CORP | 3,598,477 | 360,825,000 | 2.05% | ||
| 12 | FRANKLIN RESOURCES INC | 2,959,613 | 296,778,000 | 1.69% | ||
| 13 | FMR LLC | 2,760,941 | 276,839,000 | 1.58% | ||
| 14 | BROWN CAPITAL MANAGEMENT LLC | 2,643,420 | 265,056,000 | 1.51% | ||
| 15 | Invesco Ltd. | 2,435,283 | 244,186,000 | 1.39% | ||
| 16 | CITADEL ADVISORS LLC | 2,203,481 | 220,943,000 | 1.26% | ||
| 17 | ORBIMED ADVISORS LLC | 2,082,800 | 208,842,000 | 1.19% | ||
| 18 | CAPITAL GUARDIAN TRUST CO | 1,926,691 | 193,189,000 | 1.10% | ||
| 19 | NORGES BANK | 1,800,739 | 180,561,000 | 1.03% | ||
| 20 | FRED ALGER MANAGEMENT, LLC | 1,765,425 | 177,019,000 | 1.01% | ||
| 21 | JPMORGAN CHASE & CO | 1,497,260 | 150,294,000 | 0.86% | ||
| 22 | GOLDMAN SACHS GROUP INC | 1,416,905 | 142,074,000 | 0.81% | ||
| 23 | Matrix Capital Management Company, LP | 1,400,000 | 140,378,000 | 0.80% | ||
| 24 | AMERICAN CENTURY COMPANIES INC | 1,284,135 | 128,760,000 | 0.73% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 1,253,901 | 125,688,000 | 0.72% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,192,665 | 119,588,000 | 0.68% | ||
| 27 | Bank of New York Mellon Corp | 1,153,230 | 115,634,000 | 0.66% | ||
| 28 | BlackRock Group LTD | 1,130,737 | 113,379,000 | 0.65% | ||
| 29 | DEUTSCHE BANK AG\ | 1,120,834 | 112,382,000 | 0.64% | ||
| 30 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,104,616 | 110,760,000 | 0.63% | ||
| 31 | AMERIPRISE FINANCIAL INC | 1,103,562 | 110,656,000 | 0.63% | ||
| 32 | WELLS FARGO & COMPANY/MN | 1,100,151 | 110,313,000 | 0.63% | ||
| 33 | NORTHERN TRUST CORP | 979,102 | 98,175,000 | 0.56% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 944,258 | 94,681,000 | 0.54% | ||
| 35 | MARSHALL WACE, LLP | 940,303 | 94,285,000 | 0.54% | ||
| 36 | JENNISON ASSOCIATES LLC | 936,212 | 93,874,000 | 0.53% | ||
| 37 | TWO SIGMA ADVISERS, LP | 880,946 | 88,332,000 | 0.50% | ||
| 38 | Tekla Capital Management LLC | 880,461 | 88,284,000 | 0.50% | ||
| 39 | PICTET ASSET MANAGEMENT LTD | 803,142 | 80,531,000 | 0.46% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 763,100 | 76,516,000 | 0.44% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 742,975 | 74,498,000 | 0.42% | ||
| 42 | HealthCor Management, L.P. | 741,360 | 74,336,000 | 0.42% | ||
| 43 | VIKING GLOBAL INVESTORS LP | 730,452 | 73,242,000 | 0.42% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 679,928 | 68,177,000 | 0.39% | ||
| 45 | Legal & General Group Plc | 662,144 | 66,393,000 | 0.38% | ||
| 46 | 1832 Asset Management L.P. | 674,600 | 66,191,000 | 0.38% | ||
| 47 | Artal Group S.A. | 650,000 | 65,176,000 | 0.37% | ||
| 48 | AMUNDI ASSET MANAGEMENT US, INC. | 623,117 | 62,480,000 | 0.36% | ||
| 49 | CANADA PENSION PLAN INVESTMENT BOARD | 609,490 | 61,114,000 | 0.35% | ||
| 50 | Alyeska Investment Group, L.P. | 586,290 | 58,787,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
