| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 22,409,960 | 2,054,097,000 | 13.28% | ||
| 2 | Capital World Investors | 15,897,700 | 1,457,183,000 | 9.42% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 15,673,927 | 1,436,673,000 | 9.29% | ||
| 4 | BAKER BROS. ADVISORS LP | 14,845,559 | 1,360,744,000 | 8.80% | ||
| 5 | VANGUARD GROUP INC | 10,007,314 | 917,270,000 | 5.93% | ||
| 6 | JENNISON ASSOCIATES LLC | 4,845,182 | 444,109,000 | 2.87% | ||
| 7 | Capital International Investors | 4,293,800 | 393,570,000 | 2.55% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,823,798 | 350,489,000 | 2.27% | ||
| 9 | BB BIOTECH AG | 3,791,867 | 347,563,000 | 2.25% | ||
| 10 | FMR LLC | 3,788,723 | 347,275,000 | 2.25% | ||
| 11 | Artisan Partners Limited Partnership | 3,608,395 | 330,745,000 | 2.14% | ||
| 12 | BlackRock Fund Advisors | 3,431,151 | 314,499,000 | 2.03% | ||
| 13 | FRANKLIN RESOURCES INC | 3,055,812 | 280,094,000 | 1.81% | ||
| 14 | STATE STREET CORP | 2,797,814 | 256,439,000 | 1.66% | ||
| 15 | BROWN CAPITAL MANAGEMENT LLC | 2,696,683 | 247,178,000 | 1.60% | ||
| 16 | CAPITAL GUARDIAN TRUST CO | 2,625,527 | 240,656,000 | 1.56% | ||
| 17 | ORBIMED ADVISORS LLC | 2,622,500 | 240,378,000 | 1.55% | ||
| 18 | FIRST TRUST ADVISORS LP | 2,289,624 | 209,867,000 | 1.36% | ||
| 19 | Invesco Ltd. | 2,161,191 | 198,094,000 | 1.28% | ||
| 20 | JPMORGAN CHASE & CO | 1,606,819 | 147,281,000 | 0.95% | ||
| 21 | GILDER GAGNON HOWE & CO LLC | 1,463,618 | 134,155,000 | 0.87% | ||
| 22 | JANUS HENDERSON INVESTORS US LLC | 1,338,480 | 122,685,000 | 0.79% | ||
| 23 | SECTORAL ASSET MANAGEMENT INC | 1,336,144 | 122,471,000 | 0.79% | ||
| 24 | NORGES BANK | 1,331,389 | 122,035,000 | 0.79% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,230,955 | 112,830,000 | 0.73% | ||
| 26 | AMERIPRISE FINANCIAL INC | 1,175,138 | 107,712,000 | 0.70% | ||
| 27 | WADDELL & REED FINANCIAL INC | 1,093,722 | 100,251,000 | 0.65% | ||
| 28 | Tekla Capital Management LLC | 936,461 | 85,836,000 | 0.56% | ||
| 29 | NORTHERN TRUST CORP | 930,269 | 85,268,000 | 0.55% | ||
| 30 | BlackRock Group LTD | 905,833 | 83,029,000 | 0.54% | ||
| 31 | FRONTIER CAPITAL MANAGEMENT CO LLC | 884,596 | 81,082,000 | 0.52% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 879,012 | 80,526,000 | 0.52% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 849,354 | 77,852,000 | 0.50% | ||
| 34 | DEUTSCHE BANK AG\ | 807,713 | 74,030,000 | 0.48% | ||
| 35 | AMERICAN CENTURY COMPANIES INC | 778,546 | 71,362,000 | 0.46% | ||
| 36 | BLACKROCK ADVISORS LLC | 767,607 | 70,359,000 | 0.46% | ||
| 37 | Bank of New York Mellon Corp | 735,929 | 67,454,000 | 0.44% | ||
| 38 | CANADA PENSION PLAN INVESTMENT BOARD | 731,486 | 67,048,000 | 0.43% | ||
| 39 | CITADEL ADVISORS LLC | 683,158 | 62,618,000 | 0.40% | ||
| 40 | GOLDMAN SACHS GROUP INC | 635,832 | 58,280,000 | 0.38% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 631,163 | 57,852,000 | 0.37% | ||
| 42 | FEDERATED HERMES, INC. | 625,000 | 57,288,000 | 0.37% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 582,749 | 53,415,000 | 0.35% | ||
| 44 | TWO SIGMA ADVISERS, LP | 582,563 | 53,398,000 | 0.35% | ||
| 45 | Allianz Asset Management GmbH | 578,344 | 53,011,000 | 0.34% | ||
| 46 | CREDIT SUISSE AG/ | 562,961 | 51,602,000 | 0.33% | ||
| 47 | CAPITAL INTERNATIONAL LTD /CA/ | 554,300 | 50,807,000 | 0.33% | ||
| 48 | Artal Group S.A. | 510,000 | 46,747,000 | 0.30% | ||
| 49 | Legal & General Group Plc | 506,304 | 46,408,000 | 0.30% | ||
| 50 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 45,830,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
